TEST BANK pl
Cellular and Molecular Immunology
pl pl pl
Abul Abbas, Andrew Lichtman, and Shiv Pillai
pl pl pl pl pl pl
10th Edition
pl
,Table of Contents
pl pl
Chapter 01 Properties and Overview of Immune Responses
pl pl pl pl pl pl pl 1
Chapter 02 Cells and Tissues of the Immune System
pl pl pl pl pl pl pl pl 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
pl pl pl pl pl pl pl 6
Chapter 04 Innate Immunity
pl pl pl 10
Chapter 05 Antibodies and Antigens
pl pl pl pl 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
pl pl pl pl pl pl pl pl pl pl pl
Histocompatibility Complex Molecules pl pl 20
Chapter 07 Immune Receptors and Signal Transduction
pl pl pl pl pl pl 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
pl pl pl pl pl pl pl pl 30
Chapter 09 Activation of T Lymphocytes
pl pl pl pl pl 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
pl pl pl pl pl pl pl pl pl 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
pl pl pl pl pl pl pl pl pl 42
Chapter 12 B Cell Activation and Antibody Production
pl pl pl pl pl pl pl 46
Chapter 13 Effector Mechanisms of Humoral Immunity
pl pl pl pl pl pl 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
pl pl pl pl pl pl pl pl pl pl pl 56
Chapter 15 Immunologic Tolerance and Autoimmunity
pl pl pl pl pl 62
Chapter 16 Immunity to Microbes
pl pl pl pl 67
Chapter 17 Transplantation Immunology
pl pl pl 72
Chapter 18 Tumor Immunology
pl pl pl 77
Chapter 19 Hypersensitivity Disorders
pl pl pl 81
Chapter 20 Allergy
pl pl 86
Chapter 21 Primary and Acquired Immunodeficiencies
pl pl pl pl pl 89
,Chapter 01: Properties and Overview of Immune Responses
pl pl pl pl pl pl pl
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
pl pl pl pl pl pl pl pl pl
MULTIPLE CHOICE pl
1. The principal function of the immune system is:
pl pl pl pl pl pl pl
a. Defense against cancer pl pl
b. Repair of injured tissues pl pl pl
c. Defense against microbial infections pl pl pl
d. Prevention of inflammatory diseases pl pl pl
e. Protection against environmental toxins pl pl pl
ANS: C p l
The immune system has evolved in the setting of selective pressures imposed by microbial
pl pl pl pl pl pl pl pl pl pl pl pl pl
infections. Although immune responses to cancer may occur, the concept that
pl pl pl pl pl pl pl pl pl pl pl
“immunosurveillance” against cancer is a principal function of the immune system is
pl pl pl pl pl pl pl pl pl pl pl pl
controversial. Repair of injured tissues may be a secondary consequence of the immune
pl pl pl pl pl pl pl pl pl pl pl pl pl
responses and inflammation. Although the immune system has regulatory features that are
pl pl pl pl pl pl pl pl pl pl pl pl
needed to prevent excessive inflammation, prevention of inflammatory diseases is not a
pl pl pl pl pl pl pl pl pl pl pl pl
primary function. The immune system can protect against microbial toxins, but it generally
pl pl pl pl pl pl pl pl pl pl pl pl pl
does not offer protection against toxins of nonbiologic origin.
pl pl pl pl pl pl pl pl pl
2. Which of the following infectious diseases was prevented by the first successful
pl pl pl pl pl pl pl pl pl pl pl
vaccination?
pl
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p l
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
pl pl pl pl pl pl pl pl pl pl pl
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
pl pl pl pl pl pl pl pl pl pl pl pl pl pl pl pl
smallpox was reported to be eradicated worldwide by a vaccination program. Effective
pl pl pl pl pl pl pl pl pl pl pl pl
vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th
pl pl pl pl pl pl pl pl pl pl pl pl pl
century and are widely used. There is no effective vaccine against Mycobacterium
pl pl pl pl pl pl pl pl pl pl pl pl
tuberculosis.
pl
3. Which of the following is a unique property of the adaptive immune system?
pl pl pl pl pl pl pl pl pl pl pl pl
a. Highly diverse repertoire of specificities for antigens
pl pl pl pl pl pl
b. Self-nonself discrimination pl
c. Recognition of microbial structures by both cell-associated and soluble receptors pl pl pl pl pl pl pl pl pl
d. Protection against viral infections pl pl pl
e. Responses that have the same kinetics and magnitude on repeated exposure to the pl pl pl pl pl pl pl pl pl pl pl pl
same microbe pl pl
ANS: p l A
, Highly diverse repertoires of specificities for antigens are found only in T and B
pl pl pl pl pl pl pl pl pl pl pl pl pl
lymphocytes, which are the central cellular components of the adaptive immune system.
pl pl pl pl pl pl pl pl pl pl pl pl
Both the innate and the adaptive immune systems use cell-associated and soluble receptors
pl pl pl pl pl pl pl pl pl pl pl pl pl
to recognize microbes, display some degree of self-nonself discrimination, and protect
pl pl pl pl pl pl pl pl pl pl pl
against viruses. On repeated exposure to the same microbe, the adaptive immune response
pl pl pl pl pl pl pl pl pl pl pl pl pl
becomes more rapid and of greater magnitude; this is the manifestation of memory.
pl pl pl pl pl pl pl pl pl pl pl pl pl
4. Antibodies and T lymphocytes are the respective mediators of which two types of
pl pl pl pl pl pl pl pl pl pl pl pl
immunity?
pl
a. Innate and adaptive pl pl
b. Passive and active pl pl
c. Specific and nonspecific pl pl
d. Humoral and cell-mediated pl pl
e. Adult and neonatal pl pl
ANS: D p l
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
pl pl pl pl pl pl pl pl pl pl pl pl
produce antibodies, which are the recognition and effector molecules of humoral immune
pl pl pl pl pl pl pl pl pl pl pl pl
responses to extracellular pathogens. T cells recognize and promote eradication of
pl pl pl pl pl pl pl pl pl pl pl
intracellular pathogens in cell-mediated immunity. Passive and active immunity both can be
pl pl pl pl pl pl pl pl pl pl pl pl
mediated by either B or T lymphocytes. Specific immunity is another term for adaptive
pl pl pl pl pl pl pl pl pl pl pl pl pl pl
immunity. Both B and T lymphocytes participate in adult adaptive immunity but are still
pl pl pl pl pl pl pl pl pl pl pl pl pl pl
developing in the neonatal period.
pl pl pl pl pl
5. The two major functional classes of effector T lymphocytes are:
pl pl pl pl pl pl pl pl pl
a. Helper T lymphocytes and cytotoxic T lymphocytes pl pl pl pl pl pl
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes pl pl pl pl
c. Memory T cells and effector T cells pl pl pl pl pl pl
d. Helper cells and antigen-presenting cells pl pl pl pl
e. Cytotoxic T lymphocytes and target cells pl pl pl pl pl
ANS: A p l
T cells can be classified into effector subsets that perform different effector functions. Most
pl pl pl pl pl pl pl pl pl pl pl pl pl
effector T cells are either helper T lymphocytes, which enhance the responses of other
pl pl pl pl pl pl pl pl pl pl pl pl pl pl
immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes,
pl pl pl pl pl pl pl pl pl pl pl pl pl
which directly kill infected cells. Natural killer cells are not T lymphocytes.
pl pl pl pl pl pl pl pl pl pl pl pl
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. pl pl pl pl pl pl pl pl pl pl pl pl pl pl
6. Which of the following cell types is required for all adaptive humoral immune responses?
pl pl pl pl pl pl pl pl pl pl pl pl pl
a. Natural killer cells pl pl
b. Dendritic cells pl
c. Cytolytic T lymphocytes pl pl
d. B lymphocytes pl
e. Helper T lymphocytes pl pl
ANS: D p l
Humoral immune responses are antibody-mediated immune responses, and all antibodies
pl pl pl pl pl pl pl pl pl
are made by B lymphocytes and no other cell type.
pl pl pl pl pl pl pl pl pl pl
Cellular and Molecular Immunology
pl pl pl
Abul Abbas, Andrew Lichtman, and Shiv Pillai
pl pl pl pl pl pl
10th Edition
pl
,Table of Contents
pl pl
Chapter 01 Properties and Overview of Immune Responses
pl pl pl pl pl pl pl 1
Chapter 02 Cells and Tissues of the Immune System
pl pl pl pl pl pl pl pl 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
pl pl pl pl pl pl pl 6
Chapter 04 Innate Immunity
pl pl pl 10
Chapter 05 Antibodies and Antigens
pl pl pl pl 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
pl pl pl pl pl pl pl pl pl pl pl
Histocompatibility Complex Molecules pl pl 20
Chapter 07 Immune Receptors and Signal Transduction
pl pl pl pl pl pl 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
pl pl pl pl pl pl pl pl 30
Chapter 09 Activation of T Lymphocytes
pl pl pl pl pl 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
pl pl pl pl pl pl pl pl pl 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
pl pl pl pl pl pl pl pl pl 42
Chapter 12 B Cell Activation and Antibody Production
pl pl pl pl pl pl pl 46
Chapter 13 Effector Mechanisms of Humoral Immunity
pl pl pl pl pl pl 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
pl pl pl pl pl pl pl pl pl pl pl 56
Chapter 15 Immunologic Tolerance and Autoimmunity
pl pl pl pl pl 62
Chapter 16 Immunity to Microbes
pl pl pl pl 67
Chapter 17 Transplantation Immunology
pl pl pl 72
Chapter 18 Tumor Immunology
pl pl pl 77
Chapter 19 Hypersensitivity Disorders
pl pl pl 81
Chapter 20 Allergy
pl pl 86
Chapter 21 Primary and Acquired Immunodeficiencies
pl pl pl pl pl 89
,Chapter 01: Properties and Overview of Immune Responses
pl pl pl pl pl pl pl
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
pl pl pl pl pl pl pl pl pl
MULTIPLE CHOICE pl
1. The principal function of the immune system is:
pl pl pl pl pl pl pl
a. Defense against cancer pl pl
b. Repair of injured tissues pl pl pl
c. Defense against microbial infections pl pl pl
d. Prevention of inflammatory diseases pl pl pl
e. Protection against environmental toxins pl pl pl
ANS: C p l
The immune system has evolved in the setting of selective pressures imposed by microbial
pl pl pl pl pl pl pl pl pl pl pl pl pl
infections. Although immune responses to cancer may occur, the concept that
pl pl pl pl pl pl pl pl pl pl pl
“immunosurveillance” against cancer is a principal function of the immune system is
pl pl pl pl pl pl pl pl pl pl pl pl
controversial. Repair of injured tissues may be a secondary consequence of the immune
pl pl pl pl pl pl pl pl pl pl pl pl pl
responses and inflammation. Although the immune system has regulatory features that are
pl pl pl pl pl pl pl pl pl pl pl pl
needed to prevent excessive inflammation, prevention of inflammatory diseases is not a
pl pl pl pl pl pl pl pl pl pl pl pl
primary function. The immune system can protect against microbial toxins, but it generally
pl pl pl pl pl pl pl pl pl pl pl pl pl
does not offer protection against toxins of nonbiologic origin.
pl pl pl pl pl pl pl pl pl
2. Which of the following infectious diseases was prevented by the first successful
pl pl pl pl pl pl pl pl pl pl pl
vaccination?
pl
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p l
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
pl pl pl pl pl pl pl pl pl pl pl
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
pl pl pl pl pl pl pl pl pl pl pl pl pl pl pl pl
smallpox was reported to be eradicated worldwide by a vaccination program. Effective
pl pl pl pl pl pl pl pl pl pl pl pl
vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th
pl pl pl pl pl pl pl pl pl pl pl pl pl
century and are widely used. There is no effective vaccine against Mycobacterium
pl pl pl pl pl pl pl pl pl pl pl pl
tuberculosis.
pl
3. Which of the following is a unique property of the adaptive immune system?
pl pl pl pl pl pl pl pl pl pl pl pl
a. Highly diverse repertoire of specificities for antigens
pl pl pl pl pl pl
b. Self-nonself discrimination pl
c. Recognition of microbial structures by both cell-associated and soluble receptors pl pl pl pl pl pl pl pl pl
d. Protection against viral infections pl pl pl
e. Responses that have the same kinetics and magnitude on repeated exposure to the pl pl pl pl pl pl pl pl pl pl pl pl
same microbe pl pl
ANS: p l A
, Highly diverse repertoires of specificities for antigens are found only in T and B
pl pl pl pl pl pl pl pl pl pl pl pl pl
lymphocytes, which are the central cellular components of the adaptive immune system.
pl pl pl pl pl pl pl pl pl pl pl pl
Both the innate and the adaptive immune systems use cell-associated and soluble receptors
pl pl pl pl pl pl pl pl pl pl pl pl pl
to recognize microbes, display some degree of self-nonself discrimination, and protect
pl pl pl pl pl pl pl pl pl pl pl
against viruses. On repeated exposure to the same microbe, the adaptive immune response
pl pl pl pl pl pl pl pl pl pl pl pl pl
becomes more rapid and of greater magnitude; this is the manifestation of memory.
pl pl pl pl pl pl pl pl pl pl pl pl pl
4. Antibodies and T lymphocytes are the respective mediators of which two types of
pl pl pl pl pl pl pl pl pl pl pl pl
immunity?
pl
a. Innate and adaptive pl pl
b. Passive and active pl pl
c. Specific and nonspecific pl pl
d. Humoral and cell-mediated pl pl
e. Adult and neonatal pl pl
ANS: D p l
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
pl pl pl pl pl pl pl pl pl pl pl pl
produce antibodies, which are the recognition and effector molecules of humoral immune
pl pl pl pl pl pl pl pl pl pl pl pl
responses to extracellular pathogens. T cells recognize and promote eradication of
pl pl pl pl pl pl pl pl pl pl pl
intracellular pathogens in cell-mediated immunity. Passive and active immunity both can be
pl pl pl pl pl pl pl pl pl pl pl pl
mediated by either B or T lymphocytes. Specific immunity is another term for adaptive
pl pl pl pl pl pl pl pl pl pl pl pl pl pl
immunity. Both B and T lymphocytes participate in adult adaptive immunity but are still
pl pl pl pl pl pl pl pl pl pl pl pl pl pl
developing in the neonatal period.
pl pl pl pl pl
5. The two major functional classes of effector T lymphocytes are:
pl pl pl pl pl pl pl pl pl
a. Helper T lymphocytes and cytotoxic T lymphocytes pl pl pl pl pl pl
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes pl pl pl pl
c. Memory T cells and effector T cells pl pl pl pl pl pl
d. Helper cells and antigen-presenting cells pl pl pl pl
e. Cytotoxic T lymphocytes and target cells pl pl pl pl pl
ANS: A p l
T cells can be classified into effector subsets that perform different effector functions. Most
pl pl pl pl pl pl pl pl pl pl pl pl pl
effector T cells are either helper T lymphocytes, which enhance the responses of other
pl pl pl pl pl pl pl pl pl pl pl pl pl pl
immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes,
pl pl pl pl pl pl pl pl pl pl pl pl pl
which directly kill infected cells. Natural killer cells are not T lymphocytes.
pl pl pl pl pl pl pl pl pl pl pl pl
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. pl pl pl pl pl pl pl pl pl pl pl pl pl pl
6. Which of the following cell types is required for all adaptive humoral immune responses?
pl pl pl pl pl pl pl pl pl pl pl pl pl
a. Natural killer cells pl pl
b. Dendritic cells pl
c. Cytolytic T lymphocytes pl pl
d. B lymphocytes pl
e. Helper T lymphocytes pl pl
ANS: D p l
Humoral immune responses are antibody-mediated immune responses, and all antibodies
pl pl pl pl pl pl pl pl pl
are made by B lymphocytes and no other cell type.
pl pl pl pl pl pl pl pl pl pl
