DEEL 1
H1: ACETYLCHOLINE & CHOLINERGE RECEPTOREN
acetylcholine muscarine nicotine
M1-receptor: agonist antagonist
xanomeline
Pirenzepine
M2-receptor: antagonisten
methoctramine
AF-DX 116
M3-receptor: antagonisten
1
darifenacine
hexahydro-sila-difenidol
,Nicotine-agonisten
Relatieve activiteit
(equipotente concentratie)
R1 R2 Config. Muscarine Nicotine receptor O b a
receptor H H
H3C C O C C N(CH3)3
H H 1 1
R2 R1
CH3 (α) H R/S 49 2
H CH3 (β) R/S 1,6 180
Varenicline: partiële agonist
Ganglionblokkers
2
,Neuromusculaire blokkers
O
O N
N O
O
succinylcholine
cisatracurium
tubocurarine pancuronium R = CH3
N vecuronium R = H
N
decamethonium
mivacurium
rocuronium gallamine
Selective relaxant binding agent
suggamadex
3
, Lokale anesthetica
cocaïne benzoyltropine
oxybuprocaïne tetracaïne proxymetacaïne
b-eucaïne orthocaïne R = NH2; R' = OH
orthocaïne new R = OH; R' = NH2
benzocaïne amylocaïne procaïne
4
H1: ACETYLCHOLINE & CHOLINERGE RECEPTOREN
acetylcholine muscarine nicotine
M1-receptor: agonist antagonist
xanomeline
Pirenzepine
M2-receptor: antagonisten
methoctramine
AF-DX 116
M3-receptor: antagonisten
1
darifenacine
hexahydro-sila-difenidol
,Nicotine-agonisten
Relatieve activiteit
(equipotente concentratie)
R1 R2 Config. Muscarine Nicotine receptor O b a
receptor H H
H3C C O C C N(CH3)3
H H 1 1
R2 R1
CH3 (α) H R/S 49 2
H CH3 (β) R/S 1,6 180
Varenicline: partiële agonist
Ganglionblokkers
2
,Neuromusculaire blokkers
O
O N
N O
O
succinylcholine
cisatracurium
tubocurarine pancuronium R = CH3
N vecuronium R = H
N
decamethonium
mivacurium
rocuronium gallamine
Selective relaxant binding agent
suggamadex
3
, Lokale anesthetica
cocaïne benzoyltropine
oxybuprocaïne tetracaïne proxymetacaïne
b-eucaïne orthocaïne R = NH2; R' = OH
orthocaïne new R = OH; R' = NH2
benzocaïne amylocaïne procaïne
4
