Inhoud
Paramyxovirussen ................................................................................................................................................... 2
Taxonomie .......................................................................................................................................................... 3
Respiratory Syncytial Virus (RSV) ................................................................................................................... 3
Humaan metapneumovirus (hMPV)............................................................................................................... 5
Parainfluenza .................................................................................................................................................. 7
Bofvirus........................................................................................................................................................... 8
Andere ssRNA (-)- virussen ...................................................................................................................................... 8
Rhabdoviridae ..................................................................................................................................................... 9
Rabies (specifiek virus binnen Rhabdoviridae) ............................................................................................... 9
Filoviridae ......................................................................................................................................................... 11
Ebola (specifiek virus binnen Filoviridae) ..................................................................................................... 11
Arenaviridae ..................................................................................................................................................... 12
Bunyaviridae ..................................................................................................................................................... 13
Hantavirus (behoort tot Bunyaviridae) ........................................................................................................ 13
Influenza: griep ..................................................................................................................................................... 14
Virologie ............................................................................................................................................................ 14
HA en NA variëteit ............................................................................................................................................ 15
Spikes functies .................................................................................................................................................. 15
Variatie ............................................................................................................................................................. 15
Asian connection hypothese ........................................................................................................................ 16
Nomenclatuur ................................................................................................................................................... 16
Epidemiologie ................................................................................................................................................... 16
Klinisch beeld .................................................................................................................................................... 18
Therapie ............................................................................................................................................................ 18
Immunisatie ...................................................................................................................................................... 19
Aviaire Influenza: vogelgriep ................................................................................................................................. 20
Chronologie ...................................................................................................................................................... 20
Preventie........................................................................................................................................................... 20
Varkensgriep ......................................................................................................................................................... 21
New Jersey outbreak 1976 ............................................................................................................................... 21
Mexico outbreak 2009 ...................................................................................................................................... 21
Coronavirussen ..................................................................................................................................................... 22
Virologie ............................................................................................................................................................ 22
Virale structuur ................................................................................................................................................. 22
Taxonomie ........................................................................................................................................................ 23
Endemisch voorkomende coronavirussen ................................................................................................... 23
Hoog pathogene coronavirussen .................................................................................................................................... 24
1
,Les 6: Medisch belangrijke RNA-virussen
en hun bestrijding
1) Paramyxovirussen & ssRNA (-)-virussen
Paramyxovirussen
2
, Taxonomie
Respiratory Syncytial Virus (RSV)
VIROLOGIE
• Paramyxoviridae (diameter 100-300 nm)
• Envelopped; spikes van haemagglutinin en neuraminidase
• Single-stranded, (-)-sense RNA Reinfecties mogelijk
• Subgroepen A en B; strain variabiliteit → reinfecties mogelijk
In virale kweek
vormt het
syncytium
EPIDEMIOLOGIE
• Winterse epidemieen (Januari – Maart)
• Overdracht door respiratoir aerosol, close contact
• Infecties bij ~ 50% van kinderen < 1jaar; ~ 40% van deze infecties: LRT
• ~ Alle kinderen maken RSV infectie door tegen de leeftijd van 3 jaar
• Reinfecties mogelijk met milder klinisch beeld (URT)
RSV is de meest frequente oorzaak van LRT bij kinderen < 5 jaar
RSV in de meest voorkomende nosocomiale pathogeen in pediatrie URT = upper respiratory tract
3
LRT = lower respiratory tract
Nosocomiaal = in ziekenhuis opgelopen
Paramyxovirussen ................................................................................................................................................... 2
Taxonomie .......................................................................................................................................................... 3
Respiratory Syncytial Virus (RSV) ................................................................................................................... 3
Humaan metapneumovirus (hMPV)............................................................................................................... 5
Parainfluenza .................................................................................................................................................. 7
Bofvirus........................................................................................................................................................... 8
Andere ssRNA (-)- virussen ...................................................................................................................................... 8
Rhabdoviridae ..................................................................................................................................................... 9
Rabies (specifiek virus binnen Rhabdoviridae) ............................................................................................... 9
Filoviridae ......................................................................................................................................................... 11
Ebola (specifiek virus binnen Filoviridae) ..................................................................................................... 11
Arenaviridae ..................................................................................................................................................... 12
Bunyaviridae ..................................................................................................................................................... 13
Hantavirus (behoort tot Bunyaviridae) ........................................................................................................ 13
Influenza: griep ..................................................................................................................................................... 14
Virologie ............................................................................................................................................................ 14
HA en NA variëteit ............................................................................................................................................ 15
Spikes functies .................................................................................................................................................. 15
Variatie ............................................................................................................................................................. 15
Asian connection hypothese ........................................................................................................................ 16
Nomenclatuur ................................................................................................................................................... 16
Epidemiologie ................................................................................................................................................... 16
Klinisch beeld .................................................................................................................................................... 18
Therapie ............................................................................................................................................................ 18
Immunisatie ...................................................................................................................................................... 19
Aviaire Influenza: vogelgriep ................................................................................................................................. 20
Chronologie ...................................................................................................................................................... 20
Preventie........................................................................................................................................................... 20
Varkensgriep ......................................................................................................................................................... 21
New Jersey outbreak 1976 ............................................................................................................................... 21
Mexico outbreak 2009 ...................................................................................................................................... 21
Coronavirussen ..................................................................................................................................................... 22
Virologie ............................................................................................................................................................ 22
Virale structuur ................................................................................................................................................. 22
Taxonomie ........................................................................................................................................................ 23
Endemisch voorkomende coronavirussen ................................................................................................... 23
Hoog pathogene coronavirussen .................................................................................................................................... 24
1
,Les 6: Medisch belangrijke RNA-virussen
en hun bestrijding
1) Paramyxovirussen & ssRNA (-)-virussen
Paramyxovirussen
2
, Taxonomie
Respiratory Syncytial Virus (RSV)
VIROLOGIE
• Paramyxoviridae (diameter 100-300 nm)
• Envelopped; spikes van haemagglutinin en neuraminidase
• Single-stranded, (-)-sense RNA Reinfecties mogelijk
• Subgroepen A en B; strain variabiliteit → reinfecties mogelijk
In virale kweek
vormt het
syncytium
EPIDEMIOLOGIE
• Winterse epidemieen (Januari – Maart)
• Overdracht door respiratoir aerosol, close contact
• Infecties bij ~ 50% van kinderen < 1jaar; ~ 40% van deze infecties: LRT
• ~ Alle kinderen maken RSV infectie door tegen de leeftijd van 3 jaar
• Reinfecties mogelijk met milder klinisch beeld (URT)
RSV is de meest frequente oorzaak van LRT bij kinderen < 5 jaar
RSV in de meest voorkomende nosocomiale pathogeen in pediatrie URT = upper respiratory tract
3
LRT = lower respiratory tract
Nosocomiaal = in ziekenhuis opgelopen
