Inhoud
Genomische organisatie en morfologie .................................................................................................. 2
Taxonomie ............................................................................................................................................... 2
Taxonomie en klinische manifestaties .................................................................................................... 3
Impact van baarmoederhalskanker......................................................................................................... 4
Overleving ........................................................................................................................................... 4
Klinisch beeld....................................................................................................................................... 4
Incidentie ............................................................................................................................................. 4
Trends in incidentie van baarmoederhalskanker ............................................................................ 5
Cervicale cytologie screening .................................................................................................................. 5
Papanicolau (Pap) uitstrijkje ............................................................................................................... 5
Interpretatie ........................................................................................................................................ 5
Baarmoederhalskanker: rol van human papillomavirus (HPV) ............................................................... 6
Diagnostiek: Cytology versus Virology .................................................................................................... 6
Papillomaviridae: cancerogeen vermogen .............................................................................................. 7
Trends in incidentie van baarmoederhalskanker .................................................................................... 7
Cytologische screening: belangrijkste redenen voor de stabilisatie van de incidentie van
baarmoederhalskanker ........................................................................................................................... 8
Baarmoederhalskankerscreening programma’s wereldwijd .................................................................. 8
Wereldwijde trends in baarmoederhalsscreening .................................................................................. 8
Baarmoederhalsscreening programma’s in België.................................................................................. 9
Implementatie van HPV-gebaseerde screening op 01/01/25 ............................................................. 9
Cytologische screening .......................................................................................................................... 10
Belgische situatie (2002-2006) .......................................................................................................... 10
Belgische situatie (2013-2014) .......................................................................................................... 10
Papillomaviridae: transmissie ............................................................................................................... 10
Papillomaviridae: vaccinatie .................................................................................................................. 11
Vaccinatiedekkingsgraad/coverage HPV vaccinatie in België: “gender neutral approach”.................. 12
Wereldwijde trends en doelstellingen .................................................................................................. 12
1
, Les 5: medisch belangrijke DNA-virussen
en hun bestrijding: Papillomavirussen
Genomische organisatie en morfologie
• dsDNA, 5.3-8 kb (klein!!!)
• Geen envelop, icosahedrale symmetrie, 40-55 nm in diameter
Taxonomie
2
Genomische organisatie en morfologie .................................................................................................. 2
Taxonomie ............................................................................................................................................... 2
Taxonomie en klinische manifestaties .................................................................................................... 3
Impact van baarmoederhalskanker......................................................................................................... 4
Overleving ........................................................................................................................................... 4
Klinisch beeld....................................................................................................................................... 4
Incidentie ............................................................................................................................................. 4
Trends in incidentie van baarmoederhalskanker ............................................................................ 5
Cervicale cytologie screening .................................................................................................................. 5
Papanicolau (Pap) uitstrijkje ............................................................................................................... 5
Interpretatie ........................................................................................................................................ 5
Baarmoederhalskanker: rol van human papillomavirus (HPV) ............................................................... 6
Diagnostiek: Cytology versus Virology .................................................................................................... 6
Papillomaviridae: cancerogeen vermogen .............................................................................................. 7
Trends in incidentie van baarmoederhalskanker .................................................................................... 7
Cytologische screening: belangrijkste redenen voor de stabilisatie van de incidentie van
baarmoederhalskanker ........................................................................................................................... 8
Baarmoederhalskankerscreening programma’s wereldwijd .................................................................. 8
Wereldwijde trends in baarmoederhalsscreening .................................................................................. 8
Baarmoederhalsscreening programma’s in België.................................................................................. 9
Implementatie van HPV-gebaseerde screening op 01/01/25 ............................................................. 9
Cytologische screening .......................................................................................................................... 10
Belgische situatie (2002-2006) .......................................................................................................... 10
Belgische situatie (2013-2014) .......................................................................................................... 10
Papillomaviridae: transmissie ............................................................................................................... 10
Papillomaviridae: vaccinatie .................................................................................................................. 11
Vaccinatiedekkingsgraad/coverage HPV vaccinatie in België: “gender neutral approach”.................. 12
Wereldwijde trends en doelstellingen .................................................................................................. 12
1
, Les 5: medisch belangrijke DNA-virussen
en hun bestrijding: Papillomavirussen
Genomische organisatie en morfologie
• dsDNA, 5.3-8 kb (klein!!!)
• Geen envelop, icosahedrale symmetrie, 40-55 nm in diameter
Taxonomie
2
