TEST BANK
Basic and Clinical Pharmacology 15e
BERTRAM G. KATZUNG, ANTHONY J. TREVOR
15th Edition
, 0123456788
"#$%&#'()*%'%&#*+,#-.#&/*/01234,5(%4%/'6#478'09-:;/-9:$4"#'<
=>?@ABCDEFGACHIJKALHGMN>BO?AJCBHPQCJRSTQCJRQBUBVH@WBGATXBRJV?ALHG
DE YGJCSBZHC[LGRLGC?ILHVHR\?IWLGLSABCSLHILGBAH?@?ALBGAZ>HLS>?ULGR?
KHW@JABIAHWHRC?@>\]=N^SK?GEN>BGJCSBZHC[LGRHGA>BHGKHVHR\JGLA
?IWLGLSABCSK>BWHA>BC?@\AH@?ALBGASZ>H>?UBK?GKBCEYAA>B_J`VLKaB?VA>
QB@?CAWBGAb?GJCSB?IWLGLSABCS?WB?SVBScWJW@ScCJ`BVV?]ddX^U?KKLGBAH
?DecWHGA>cHVIK>LVI?S?CHJALGBLWWJGLf?ALHGEg>LK>`C?GK>HP
@>?CW?KHVHR\`BSAIBSKCL̀BSA>B?KALHGSHP?VVA>CBBGJCSBSh
Y^ _>?CW?KHBKHGHWLKS
i^ _>?CW?KHA>BC?@BJALKS
=^ _>?CW?KHI\G?WLKS
Q^ _>?CW?KH[LGBALKS
YGSM i
jBBI`?K[M
_>?CW?KHVHR\LSA>BSAJI\HPA>B`LHVHRLKBPPBKASHPK>BWLK?VSEOJCSBS?CB
LGUHVUBIZLA>KVLGLK?V@>?CW?KHVHR\HC@>?CW?KHA>BC?@BJALKSbZ>LK>LS?
`C?GK>HP@>?CW?KHVHR\A>?AIB?VSZLA>A>BJSBSHPICJRSAHACB?Ab@CBUBGAb
?GIIL?RGHSBILSB?SBEN>BC?ILHVHR\GJCSBLS?IWLGLSABCLGR?ICJRAH>BV@
IL?RGHSB?ILSB?SBEN>BHGKHVHR\GJCSBLS?IWLGLSABCLGR?ICJRAH>BV@ACB?A?
ILSB?SBE_>?CW?KHBKHGHWLKSLGKVJIBS?G\KHSASLGUHVUBILGICJRA>BC?@\E
_>?CW?KHI\G?WLKSLGUHVUBS>HZ?ICJR?PPBKASA>B`HI\?GI
@>?CW?KH[LGBALKSLS>HZA>B`HI\?KASHGA>B`HI\E
4E g>BGLGUHVUBILG@>?SBFFFICJRBU?VJ?ALHGSAJILBSbZ>?ACBS@HGSL̀LVLALBS
ZHJVIA>BGJCSB>?UBh
Y^ gHC[LGRZLA>?GLW?VSZ>H?CBRLUBGBk@BCLWBGA?VICJRS
i^ =>HHSLGR?@@CH@CL?AB@?ALBGASAH`BLGUHVUBILGA>BICJRSAJI\
=^ dHGLAHCLGR?GIH`SBCULGR@?ALBGASKVHSBV\PHC?IUBCSBBPPBKAS
Q^ =HGIJKALGRCBSB?CK>AHIBABCWLGBBPPBKALUBGBSSHPA>BICJR
15!
999
, 0123456788
"#$% &
'(()*+,-%
./+$(000$12)3($3#4564(2$(57+)8293#+4+$1,63#3,+6:5:26+135#3#;/3,/
:+13(#1$+8(+$-()158(,58)+#<$<=:15=$1/(<(>:(83(#,(;/36(1+-3#91/(
)829$?@28$($=+<*(8($:5#$3*6(758/(6:3#9,566(,1+#)+#+6<A(1/(
3#758=+135#15*($/+8();31/1/('55)+#)B829")=3#3$18+135#C'B"D*21
;526)#51,5#)2,18($(+8,/3#)(:(#)(#16<*(,+2$(#28$($)5#51:8($,83*(
=()3,+135#$?E$(57+#3=+6$3#)8291($13#93$)5#(3#1/(:8(,63#3,+6183+6$?
F(6(,1:+13(#1$;/5+8(3#4564()3#:/+$(00$12)3($15:+813,3:+1(3#$12)3($
;/(8(1/(:+813,3:+#1$/+4(1/()3$(+$(1/()8293$3#1(#)()1518(+1?G/($(
:+13(#1$+8(=5#3158(),65$(6<758)829+,135#+#)+)4(8$((77(,1$?./+$(0
$12)3($3#4564(/(+61/</2=+#4562#1((8$;/5+8(2$2+66<:+3)7581/(38
:+813,3:+135#?@28$($=+<5*$(84(758+)4(8$((77(,1$+#)15>3,31<?
4? ":/<$3,3+#/+$58)(8()3#18+=2$,26+8C0HD3#I(,135#$57=58:/3#(J+
#+8,513,J(4(8<K/528$+$#(()()758:+3#3#+=51584(/3,6(+,,3)(#143,13=?
G/(#28$(3$+;+8(1/3$)829/+$+/39/+*2$(:51(#13+6?E#)(8;/+1,+1(958<
;526)=58:/3#(*(,6+$$373()L
"D F,/()26(0
MD F,/()26(00
&D F,/()26(000
BD F,/()26(0N
"#$% M
'(()*+,-%
@+8,513,$;31/+/39/+*2$(:51(#13+6+8(,6+$$373()+$F,/()26(00)829$
*(,+2$(57$(4(8()(:(#)(#,(63+*3631<?F,/()26(0)829$/+4(/39/+*2$(
:51(#13+6+#)#5+,,(:1()=()3,+62$(?F,/()26(000)829$/+4(+6($$(8
+*2$(:51(#13+61/+#00+#)+#+,,(:1()=()3,+62$(?F,/()26(0N)829$/+4(
65;+*2$(:51(#13+6+#)63=31())(:(#)(#,(63+*3631<?
15!
999
, 0123456788
4" #$%&'()'*+&,-'()-,.*/*.0$*)1*)*/,'./21-%/*-23-&,&2&*.4(/3/%).
)%5*./21-6
78 9,(%:%,;%3,;,&<
98 =/,&,'%;'()'*)&/%&,()
=8 >,-&/,32&,()
>8 ?%;4@;,4*
7)-A 7
B**.3%'CA
9,(%:%,;%3,;,&<,-&$*+(/&,()(4%.(-*(4%./21&$%&/*%'$*-&$*-<-&*5,'
',/'2;%&,()%).,-%:%,;%3;*&(%'&()3(.<'*;;-"9,).*/-2-*.,)%1*)*/,'
./215%<)(&3*&$*-%5*%-&$(-*2-*.,)&$*3/%).)%5*./21"D$*/*4(/*E
&$*0%<&$*3(.<3/*%C-.(0)%).2-*-&$*./215%<.,44*/E0$,'$5%<
*;,5,)%&*%1*)*/,'./21-23-&,&2&,()"=/,&,'%;'()'*)&/%&,(),-&$*%5(2)&(4
%./21&$%&,-)**.*.&('%2-*%&$*/%+*2&,'*44*'&%).-$(2;.)(&.,44*/
3*&0**)1*)*/,'%).3/%).)%5*5*.,'%&,()-">,-&/,32&,(),-&$*+$%-*(4
+$%/5%'(C,)*&,'-E0$,'$,):(;:*-&$*5(:*5*)&(4%./21&(&$*3(.<-
&,--2*-%).,-&$*-%5*,)1*)*/,'%).3/%).)%5*./21-"7./21-$%;4@;,4*,-
&$*&,5*,&&%C*-4(/&$*%5(2)&(4./21&(.*'/*%-*&($%;4&$*+*%C;*:*;E
0$,'$-$(2;.)(&'$%)1*0$*)-23-&,&2&,)1%1*)*/,'5*.,'%&,()"
F" 7)2/-*,-%--*--,)1&$*+%&,*)&-$(5*5*.,'%&,()2-*"74&*/;,-&*),)1&(&$*
+%&,*)&;,-&'2//*)&5*.,'%&,()-E&$*)2/-*%-C-0$%&+/,(/,&<G2*-&,()6
78 >(<(2&%C*%)<1*)*/,'5*.,'%&,()-6
98 7/*%)<(4&$*-*5*.,'%&,()-(/+$%)./21-6
=8 7/*&$*-*5*.,'%&,()--%4*&(&%C*.2/,)1+/*1)%)'<6
>8 >(<(2&%C*%)<(:*/@&$*@'(2)&*/5*.,'%&,()-6
7)-A >
B**.3%'CA
15!
999
Basic and Clinical Pharmacology 15e
BERTRAM G. KATZUNG, ANTHONY J. TREVOR
15th Edition
, 0123456788
"#$%&#'()*%'%&#*+,#-.#&/*/01234,5(%4%/'6#478'09-:;/-9:$4"#'<
=>?@ABCDEFGACHIJKALHGMN>BO?AJCBHPQCJRSTQCJRQBUBVH@WBGATXBRJV?ALHG
DE YGJCSBZHC[LGRLGC?ILHVHR\?IWLGLSABCSLHILGBAH?@?ALBGAZ>HLS>?ULGR?
KHW@JABIAHWHRC?@>\]=N^SK?GEN>BGJCSBZHC[LGRHGA>BHGKHVHR\JGLA
?IWLGLSABCSK>BWHA>BC?@\AH@?ALBGASZ>H>?UBK?GKBCEYAA>B_J`VLKaB?VA>
QB@?CAWBGAb?GJCSB?IWLGLSABCS?WB?SVBScWJW@ScCJ`BVV?]ddX^U?KKLGBAH
?DecWHGA>cHVIK>LVI?S?CHJALGBLWWJGLf?ALHGEg>LK>`C?GK>HP
@>?CW?KHVHR\`BSAIBSKCL̀BSA>B?KALHGSHP?VVA>CBBGJCSBSh
Y^ _>?CW?KHBKHGHWLKS
i^ _>?CW?KHA>BC?@BJALKS
=^ _>?CW?KHI\G?WLKS
Q^ _>?CW?KH[LGBALKS
YGSM i
jBBI`?K[M
_>?CW?KHVHR\LSA>BSAJI\HPA>B`LHVHRLKBPPBKASHPK>BWLK?VSEOJCSBS?CB
LGUHVUBIZLA>KVLGLK?V@>?CW?KHVHR\HC@>?CW?KHA>BC?@BJALKSbZ>LK>LS?
`C?GK>HP@>?CW?KHVHR\A>?AIB?VSZLA>A>BJSBSHPICJRSAHACB?Ab@CBUBGAb
?GIIL?RGHSBILSB?SBEN>BC?ILHVHR\GJCSBLS?IWLGLSABCLGR?ICJRAH>BV@
IL?RGHSB?ILSB?SBEN>BHGKHVHR\GJCSBLS?IWLGLSABCLGR?ICJRAH>BV@ACB?A?
ILSB?SBE_>?CW?KHBKHGHWLKSLGKVJIBS?G\KHSASLGUHVUBILGICJRA>BC?@\E
_>?CW?KHI\G?WLKSLGUHVUBS>HZ?ICJR?PPBKASA>B`HI\?GI
@>?CW?KH[LGBALKSLS>HZA>B`HI\?KASHGA>B`HI\E
4E g>BGLGUHVUBILG@>?SBFFFICJRBU?VJ?ALHGSAJILBSbZ>?ACBS@HGSL̀LVLALBS
ZHJVIA>BGJCSB>?UBh
Y^ gHC[LGRZLA>?GLW?VSZ>H?CBRLUBGBk@BCLWBGA?VICJRS
i^ =>HHSLGR?@@CH@CL?AB@?ALBGASAH`BLGUHVUBILGA>BICJRSAJI\
=^ dHGLAHCLGR?GIH`SBCULGR@?ALBGASKVHSBV\PHC?IUBCSBBPPBKAS
Q^ =HGIJKALGRCBSB?CK>AHIBABCWLGBBPPBKALUBGBSSHPA>BICJR
15!
999
, 0123456788
"#$% &
'(()*+,-%
./+$(000$12)3($3#4564(2$(57+)8293#+4+$1,63#3,+6:5:26+135#3#;/3,/
:+13(#1$+8(+$-()158(,58)+#<$<=:15=$1/(<(>:(83(#,(;/36(1+-3#91/(
)829$?@28$($=+<*(8($:5#$3*6(758/(6:3#9,566(,1+#)+#+6<A(1/(
3#758=+135#15*($/+8();31/1/('55)+#)B829")=3#3$18+135#C'B"D*21
;526)#51,5#)2,18($(+8,/3#)(:(#)(#16<*(,+2$(#28$($)5#51:8($,83*(
=()3,+135#$?E$(57+#3=+6$3#)8291($13#93$)5#(3#1/(:8(,63#3,+6183+6$?
F(6(,1:+13(#1$;/5+8(3#4564()3#:/+$(00$12)3($15:+813,3:+1(3#$12)3($
;/(8(1/(:+813,3:+#1$/+4(1/()3$(+$(1/()8293$3#1(#)()1518(+1?G/($(
:+13(#1$+8(=5#3158(),65$(6<758)829+,135#+#)+)4(8$((77(,1$?./+$(0
$12)3($3#4564(/(+61/</2=+#4562#1((8$;/5+8(2$2+66<:+3)7581/(38
:+813,3:+135#?@28$($=+<5*$(84(758+)4(8$((77(,1$+#)15>3,31<?
4? ":/<$3,3+#/+$58)(8()3#18+=2$,26+8C0HD3#I(,135#$57=58:/3#(J+
#+8,513,J(4(8<K/528$+$#(()()758:+3#3#+=51584(/3,6(+,,3)(#143,13=?
G/(#28$(3$+;+8(1/3$)829/+$+/39/+*2$(:51(#13+6?E#)(8;/+1,+1(958<
;526)=58:/3#(*(,6+$$373()L
"D F,/()26(0
MD F,/()26(00
&D F,/()26(000
BD F,/()26(0N
"#$% M
'(()*+,-%
@+8,513,$;31/+/39/+*2$(:51(#13+6+8(,6+$$373()+$F,/()26(00)829$
*(,+2$(57$(4(8()(:(#)(#,(63+*3631<?F,/()26(0)829$/+4(/39/+*2$(
:51(#13+6+#)#5+,,(:1()=()3,+62$(?F,/()26(000)829$/+4(+6($$(8
+*2$(:51(#13+61/+#00+#)+#+,,(:1()=()3,+62$(?F,/()26(0N)829$/+4(
65;+*2$(:51(#13+6+#)63=31())(:(#)(#,(63+*3631<?
15!
999
, 0123456788
4" #$%&'()'*+&,-'()-,.*/*.0$*)1*)*/,'./21-%/*-23-&,&2&*.4(/3/%).
)%5*./21-6
78 9,(%:%,;%3,;,&<
98 =/,&,'%;'()'*)&/%&,()
=8 >,-&/,32&,()
>8 ?%;4@;,4*
7)-A 7
B**.3%'CA
9,(%:%,;%3,;,&<,-&$*+(/&,()(4%.(-*(4%./21&$%&/*%'$*-&$*-<-&*5,'
',/'2;%&,()%).,-%:%,;%3;*&(%'&()3(.<'*;;-"9,).*/-2-*.,)%1*)*/,'
./215%<)(&3*&$*-%5*%-&$(-*2-*.,)&$*3/%).)%5*./21"D$*/*4(/*E
&$*0%<&$*3(.<3/*%C-.(0)%).2-*-&$*./215%<.,44*/E0$,'$5%<
*;,5,)%&*%1*)*/,'./21-23-&,&2&,()"=/,&,'%;'()'*)&/%&,(),-&$*%5(2)&(4
%./21&$%&,-)**.*.&('%2-*%&$*/%+*2&,'*44*'&%).-$(2;.)(&.,44*/
3*&0**)1*)*/,'%).3/%).)%5*5*.,'%&,()-">,-&/,32&,(),-&$*+$%-*(4
+$%/5%'(C,)*&,'-E0$,'$,):(;:*-&$*5(:*5*)&(4%./21&(&$*3(.<-
&,--2*-%).,-&$*-%5*,)1*)*/,'%).3/%).)%5*./21-"7./21-$%;4@;,4*,-
&$*&,5*,&&%C*-4(/&$*%5(2)&(4./21&(.*'/*%-*&($%;4&$*+*%C;*:*;E
0$,'$-$(2;.)(&'$%)1*0$*)-23-&,&2&,)1%1*)*/,'5*.,'%&,()"
F" 7)2/-*,-%--*--,)1&$*+%&,*)&-$(5*5*.,'%&,()2-*"74&*/;,-&*),)1&(&$*
+%&,*)&;,-&'2//*)&5*.,'%&,()-E&$*)2/-*%-C-0$%&+/,(/,&<G2*-&,()6
78 >(<(2&%C*%)<1*)*/,'5*.,'%&,()-6
98 7/*%)<(4&$*-*5*.,'%&,()-(/+$%)./21-6
=8 7/*&$*-*5*.,'%&,()--%4*&(&%C*.2/,)1+/*1)%)'<6
>8 >(<(2&%C*%)<(:*/@&$*@'(2)&*/5*.,'%&,()-6
7)-A >
B**.3%'CA
15!
999
