APHON Chemo Agents & Classifications
Alkylating agents - non-particular. Although most lively in resting segment. Reason dna strand
breaks
anthracyclines - prevent rejoining of cleaved dna strands via inhibiting topoisomerase ii (dna
untangling enzyme). Also bureaucracy hydroxyl radicals which assault dna/cell membrane lipids
(cardiotoxic)
provide cardioprotective marketers along
abx are subset but breakdown is commonly strong
antiangiogenic retailers - pvt boom of latest blood vessels tumors rely on for boom and
metastases with the aid of:
inhibit endothelial cells, interrupt messaging procedure, save you breakdown of matrix tissue
and pvt new cells from linking together to form new vessels
antimetabolites - intervene w/ cellular metabolism via inhibiting enzyme manufacturing or
producing nonfunctional stop product. Interrupts protein synthesis, rna, or dna
asparaginase - misc agent. L/PEG: cell-cycle non-particular enzyme, covered w/ polyethylene
glycol & decreases immunogenicity of enzyme.
Camptothecin - topotecan, irinotecan
inhibit topoisomerase i causing dna-strand breaks & mobile demise
cellular cycle non-specific - dismiss phase. Dose structured. Powerful on slow growing cancer
cells b/c cytotoxic in resting section as well. Degree of cell kill immediately correlates to dose
administered
mobile cycle precise - affective all through precise section, w/ maximal effect on rapidly dividing
cells
corticosteroids - modifies transcription method in dna formation
dexamethasone, prednisone
epipodophyllotoxins - etoposide, teniposide
inhibit topoisomerase ii and bring dna-strand breaks
mobile cycle specific
hydroxurea - misc agent.
Inhibits dna synthesis inflicting mobile demise in s segment
Alkylating agents - non-particular. Although most lively in resting segment. Reason dna strand
breaks
anthracyclines - prevent rejoining of cleaved dna strands via inhibiting topoisomerase ii (dna
untangling enzyme). Also bureaucracy hydroxyl radicals which assault dna/cell membrane lipids
(cardiotoxic)
provide cardioprotective marketers along
abx are subset but breakdown is commonly strong
antiangiogenic retailers - pvt boom of latest blood vessels tumors rely on for boom and
metastases with the aid of:
inhibit endothelial cells, interrupt messaging procedure, save you breakdown of matrix tissue
and pvt new cells from linking together to form new vessels
antimetabolites - intervene w/ cellular metabolism via inhibiting enzyme manufacturing or
producing nonfunctional stop product. Interrupts protein synthesis, rna, or dna
asparaginase - misc agent. L/PEG: cell-cycle non-particular enzyme, covered w/ polyethylene
glycol & decreases immunogenicity of enzyme.
Camptothecin - topotecan, irinotecan
inhibit topoisomerase i causing dna-strand breaks & mobile demise
cellular cycle non-specific - dismiss phase. Dose structured. Powerful on slow growing cancer
cells b/c cytotoxic in resting section as well. Degree of cell kill immediately correlates to dose
administered
mobile cycle precise - affective all through precise section, w/ maximal effect on rapidly dividing
cells
corticosteroids - modifies transcription method in dna formation
dexamethasone, prednisone
epipodophyllotoxins - etoposide, teniposide
inhibit topoisomerase ii and bring dna-strand breaks
mobile cycle specific
hydroxurea - misc agent.
Inhibits dna synthesis inflicting mobile demise in s segment
