Rh antigens - Answers IgG
Reaction phase: AHG/37 degree
Enhanced by enzymes
Complement does NOT bind
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D, C, c , E,e, Cw
e antigen - Answers Highest incidence of WAIHA
Cw antigen - Answers Low incidence Rh antigen
Lewis antigens - Answers IgM
Immediate spin/RT reaction phase
Enhanced by enzymes
No HDFN; occasionally HTR
Can bind complement
Plasma antigens - only antigen system not manufactured by the RBC; made by tissue cells, secreted into
body fluid, and adsorbed onto RBC
Lewis A & B
I antigens - Answers IgM
Immediate spin/RT reaction phase
Enhanced by enzymes
Complement does bind
I (adult cells), i (chord cells)
i antigen - Answers Associated with infectious mononucleosis; transient but potent
Present on chord blood cells
P antigens - Answers IgM
, Immediate spin/RT reaction phase
Enhanced by enzymes
Complement does bind
P, P1
P antigen - Answers Auto anti-P causes PCH; IgG that fixes complement at 4 degrees & Lydia occurs at 37
Auto anti-P = donath landSteiner antibody
MNSs antigens - Answers IgM/immediate spin/RT- MN
IgG/AHG/37 - Ss
*Destroyed by enzymes
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M,N,S,s
Lutheran antigens - Answers IgM
Immediate spin/RT
Variable enzyme effect
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Linked to Se gene
Not very antigenic
*characteristic fragile agglutination
Only system in which a dominant gene produces a minus minus phenotype (Lu a-b-)
Lutheran A & B
Kell - Answers IgG
AHG/37 degree reaction phase
Enzymes have NO effect
Are able to bind complement