NR-603-Week 1-Parkinsons Exam Questions and Answers | 100% Pass

NR-603-Week 1-Parkinsons Exam Questions and Answers | 100% Pass Parkinson disease (PD) is a - Answer️️ -slowly progressive neurodegenerative disease with an insidious onset of the cardinal features of asymmetric resting tremor, bradykinesia, and rigidity, commonly with postural changes cardinal features of Parkinsons are - Answer️️ -asymmetric resting tremor, bradykinesia, and rigidity, commonly with postural changes Parkinsons is a result of - Answer️️ -dopamine depletion which results in increased inhibition of the thalamus and reduced excitatory input to the motor cortex, Resting tremor - Answer️️ -is present at rest, i s usually unilateral at first characteristically disappears with action. Rest tremor of the hands, described as - Answer️️ -"pill rolling," increases with walking and may be an early sign when others are not yet present ©SOPHIABENNETT EXAM SOLUTIONS_2024/2025 Tuesday, September 3, 2024 10:30 AM Page | 2 Another classic symptom of Parkinsons is rigidity. Rigidity is - Answer️️ -an increased resistance to passive movement at a joint, usually manifests with a ratcheting or "cogwheeling" during the movement. The patient with PD often has a uniquely flexed posture involving the entire body. Describe this posture - Answer️️ -The head is bowed; the trunk is bent forward; the back is kyphotic; the hands are held in front of the body; and the elbows, hips, and knees are flexed. treatment for Parkinsons which is both diagostic and therapeutic - Answer️️ -levodopa, Diagnostic tests for Parkinson's - Answer️️ -not indicated The "gold standard" for diagnosis is postmortem neuropathologic examination, especially noting midbrain Lewy bodies. When is the decision made to initiate medical therapy - Answer️️ -determined by the degree of functional impairment. Important factors include the effect of disease on the dominant hand and the degree of interference with work, activities of daily living, and social and leisure function. ©SOPHIABENNETT EXAM SOLUTIONS_2024/2025 Tuesday, September 3, 2024 10:30 AM Page | 3 Selegiline (Eldepryl), - Answer️️ -a selective monoamine oxidase type B inhibitor, may have neuroprotective properties and can be modestly effective in treatment. Selegiline may delay the destruction of the nigral neurons and inhibit the metabolic breakdown of dopamine maximum dose is currently considered to be 5 mg twice daily What is the most effective drug for the symptomatic treatment of Parkinson's - Answer️️ -Levadopa Levodopa treatment is aimed at - Answer️️ -restoration of the amount of dopamine reaching the basal ganglia. Sinemet combines levodopa with carbidopa, which blocks peripheral metabolism, this does what? - Answer️️ -allows much more of the levodopa to enter the brain than if it were given alone Treatment of Sinmet (Carbidopa/Levadopa) should begin with - Answer️️ -small doses, one half of Sinemet 25/100 two or three times a day with meals and titrated to the lowest levodopa dose that produces a useful clinical response. What is the optimum dose of carbidopa - Answer️️ -10