UNE Biochemistry Final Graded A

UNE Biochemistry Final Graded A The glucose-alanine cycle is a method of transferring ammonia from the skeletal muscle to the liver. In this process the non-toxic carrier of ammonia is which of the following compounds? ️Alanine Which of the following enzymes is correctly paired with its activator? ️N-acetylglutamate synthatase; arginine The urea cycle takes place in which of the following subcellular locations? ️the cytosol and the mitochondria Which of the following enzymes is regulated by N-acetylglutamate (NAGs)? ️CPS I Which of the following enzymes is the regulatory step in the urea cycle? ️Carbamoyl phosphate synthetase I (CPS I) Which of the following statements is consistent with nitrogen transport in the fasted state? ️The urea cycle will be active A comatose infant is brought to the ER. In the course of the examination, plasma ammonia was found to be elevated 20-fold over normal values. Urine orotic acid and uracil were both greater than normal. A defect of which of the following enzymes is the most likely diagnosis? ️Ornithine transcarbamoylase Your patient presents with a deficiency of the enzyme that catalyzes synthesis of N-acetylglutamate (NAGs). Which of the following would be a consequence of this deficiency in the patient? ️Increased amino acids in the blood The cellular uptake of LDL increases intracellular cholesterol levels. This has which of the following impacts on de novo cholesterol synthesis? ️Increases degradation of HMG-CoA reductase Dietary cholesterol is primarily transported in the body by which of the following lipoproteins? ️Chylomicron Secondary bile salts are generated by bacterial modification of primary bile salts in the intestinal lumen. These modifications have which of the following impacts on bile salt solubility? ️Decrease solubility A 47-year-old male is prescribed a statin (HMG-CoA reductase inhibitor) to manage his elevated LDL cholesterol. What is the initial mechanism of action for obtaining the desired effect in this man? ️Decreasing hepatic cholesterol biosynthesis A deficiency in the LDL receptor will result in an initial decrease in which of the following? ️Intracellular cholesterol A 45-year-old man has a mild heart attack and a history of vascular disease. He is placed on a Mediterranean diet and statin drug therapy. Which of the following will be the most likely result of this drug therapy? ️Low blood LDLs A 45-year-old man is found to have an elevated serum triglycerides of > 730mg/dL. He tells you he forgot to fast before his visit and he ate a full breakfast of bacon and eggs before the labs were drawn. Which of the following lipoproteins would be the largest contributors to a measurement of plasma triglycerides in this situation? ️Chylomicrons and VLDLs In the reaction catalyzed by cholesterol ester transfer protein (CETP), the VLDL particle receives which of the following compounds from HDL particles? ️Cholesterol-ester In reverse cholesterol transport HDL interacts with the ABCA1 transporter to move cholesterol from the cell to the HDL. This also requires the activity of which of the following enzyme? ️Lecithin cholesterol acyltransferase (LCAT) HDL particles interact with VLDL particles to exchange cholesterol ester for triacylglyerols. Which of the following enzymes is responsible for this process? ️Cholesterol ester transfer protein (CETP)