UNE: BIOCHEMISTRY UNIT 1 & 2 CASE STUDY GUIDE QUESTIONS AND ANSWERS(DIAGRAMS INCLUDED
UNE: BIOCHEMISTRY UNIT 1 & 2 CASE STUDY GUIDE QUESTIONS AND ANSWERS(DIAGRAMS INCLUDED) Folding of the secondary structures A 19-year-old male is diagnosed with Creutzfeldt-Jakob Disease, which is caused by the introduction of an amyloid fold in the disease-causing protein. The introduction of this fold causes the protein to transition from a primarily α-helical structure to an aggregate of mostly β-sheets. This change in protein structure (leading to disease) is best attributed to changes in which of the following? 3 MULTIPLE CHOICE OPTIONS It reduces the catalytic activity of the enzyme A 28-year-old male is recently diagnosed with HIV. As part of his treatment, he is prescribed Nevirapine which interferes with retroviral reverse transcriptase enzyme. Using the graph below, which of the following best describes the impact of this drug on its target? - It increases the rate of the reaction - It reduces the catalytic activity of the enzyme - It decreases the Km of its substrate - It irreversibly inhibits the enzyme - It Increases the Km of its substrate 3 MULTIPLE CHOICE OPTIONS Substrates or ligands that bind the active site Children with cystinosis have growth delay and both renal and ocular issues due to the accumulation of cystine in cellular lysosomes. Effective therapy has been the administration of a drug with a similar structure to cystine. This therapy reflects the general principle that competitive inhibitors typically resemble the structure of which of the following? The cofactor Enzyme or receptor protein An allosteric regulator of enzyme Substrates or ligands that bind the active site Enzyme reaction products 3 MULTIPLE CHOICE OPTIONS Hypoglycemia A 5-ye
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une biochemistry unit
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une biochemistry
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biochemistry
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une biochemistry unit 1 2 case study guide ques
