Chemotherapy/Immunotherapy Certificate Course (ONS,ONCC) | Questions and Answers(A+ Solution guide)

Alkylating agents - Classification Break DNA helix strand, thereby interfering with DNA replication Altretamine (Hexalen) - Alkylating Agent PO Ovarian CA Side effects- nausea, vomiting, skin rash, hypersensitivity reaction, diarrhea Dose limiting - neuro-toxicity, peripheral neuropathy, myelosuppression Bendamustine (Treanda/Bendeka) - Alkylating agent IV CLL or Indolent NHL Side effects- pyrexia, nausea, vomiting, skin reactions, TLS, hepatotoxicity, vein irritation Dose limiting - myelosuppression Irritant and vesicant properties infusion reactions likely to occur in 2nd or subsequent infusions Busulfan (IV busulfex: PO Myleran) - Alkylating Agent IV or PO CML and Stem cell prep Side effects - profound tachycardia, HTN, chest pain, hyperpigmentation, alopecia, infertility, confusion, suizures, mucositis, nausea, vomiting, insomnia, hyperglycemia, blurred vision, secondary malignancy, VOD (now sinusoidal obstruction syndrome)