PTCB: Compounding questions and answers with verified content

PTCB: Compounding questions and answers with verified content act of reducing a substance to small, fine particles comminution to scatter or incorporate the particles of one substance into another dispense the act of dissolving a substance into a liquid dissolution a sweetened hydroalcoholic solution which may contain an active ingredient or serve as a vehicle for another medication; binder/filler to mask the actual taste of the medication Elixir A mixture of two liquids that are not soluble in each other. when shaken, one phase will form globules in the other. Emulsions inert substances added to another substances in order to attain suitable consistency, shape or form (tablets fillers and binders excipients used to combine one drug with another in a mortar and the smaller amount, usually the active ingredients into mortar then add the same amount of the next ingredient geometric dilution a water loving substance hydrophilic water hating or oil loving substance hydrophobic using a spatula to mix, smooth, or dispense a solid, semisolid, or liquid into an ointment base levigation a semisolid dosage with a petroleum or fatty bee meant for topical application ointment substances added that are intended to maintain sterility by killing or inhibiting growth of bacteria or other organism preservatives method for filling capsules in which the body of a capsule is repeatedly punched into a cake of medication until the capsule is full punch method a liquid dosage form in which active ingredient are dissolved in a liquid vehicle solution to add slowly sprinkle mixing a substance using a stir rod or other appropriate tool, without the use of a stir bar stir by hand mixing or agitation a substance using a stir bar and magnetic stir function of the hot plate stirring surface acting agent. a substance used to lower the surface tension of a liquid to facilitate compounding surfactant insoluble substance held in dispersion by an agent to prevent separation or settling suspension controlled sucrose solution suitably flavored and intended as a vehicle or base or the active ingredient. Must be preserved with an antibacterial anti fungal ingredient syrup to reset the balance to zero tare grinding or mixing dry powders in a mortar and pestle to reduce particle size trituration a whorled arrangement, design, or pattern created by the spin bar and the magnetic stir function of the hot plate vortex two pan balance, used weight small amounts class III prescription balance two pan balance, used for larger weights counterbalance single pan, easier to operate than two pan balance, more accurate digital electronic balance used with two-pan balances to offset ingredients weight; made of polished brass with noncorrosive coating pharmaceutical weights used to transfer solid ingredients to weighing pans, ointments and creams, remove material from mortar pestle spatulas glass stirring rod used for grasping objects; used with pharmaceutical weights to avoid transferring moisture or oil from hands forceps plate made of ground glass; disposable nonabsorbent parchment paper compounding slab used in measuring liquids; used to measure liquid used for grinding and mixing ingredients mortar and pestle used for storing ingredients and final products freezers and refrigerators protection when working with powders container hood, mask, and gowns used for combining tablet ingredients tablet press used for making larger quantities of capsules capsule machine other equipment tong, hot plate, ointment jar, troche mold, suppository mold, thermometer, braun, homogenizer Many compounding pharmacy seek national accreditation protects patient, protect business, differentiate their practice from other pharmacies responsible for accrediting pharmacies PCAB to be accredited must follow all specific standards follow continuous quality improvement process including periodic spot checks, random selection of product to be analyzed at an outside lab 2. certification of pharmacy technician certification of pharmacy technician in compounding 1. pass PTCB; 2. complete mini-certifications and laboratory training; 3. all compounding task must be supervised and checked by the pharmacist. USP chapter 795 only USP or National formulary ingredients should be used; pharmacist balance cost of ingredients with quality;3. pharmacist must have multiple sources of ingredients Material Safety Data Sheet must be filed with for all stored ingredients; contain information on: 1. hazard and flammability, how to clean up spills, procedures for treating accidental ingestion or exposure estimated for beyond-use dating refrigerated solutions: 14 days solids and solutions: 6 months or less; all other formulations: 30 days * if using other ingredients and may expire sooner than 6 months, that will be the expiration date ... manufactured or bulk materials 25% of the remaining expiration date; 6 months earlier a patient-specific medication prepared on-site by the technician, under the supervision of the pharmacist, from individual ingredients compounded preparations products prepared off-site by a manufacturer, mass production manufactured products recipe for maing the compound prescriptions master control record - prepared by pharmacist or compounding service master control record list: drug's name, strength, dosage form, ingredients and quantities, mixing instructions, recommended beyond use dating, storing and labeling requirements ff ... generated foe each prescription; use by pharmacist to complete initial calculation and documenting them compounding log; copy of the log prescription record compounding log list ingredients, manufacturer, wholesaler source, assigned lot number, NC number, expiration date of ingredients; quantity made, date of compounding, initials of pharmacist and compounding technicians