Vladislavshuryghin

This resource contains two complete, exam‑style essays written under timed conditions for the Cell Signalling & Therapeutics module (University of Sussex, Third Year). Essay 1 (HER2 breast cancer): Explains the HER2–Ras–Raf–MEK–ERK signalling cascade and how ERK activation in HER2‑positive breast cancer develops resistance to receptor‑targeted therapies. Discusses mechanisms such as receptor bypass, B‑Raf mutations, and PI3K/AKT activation. Evaluates therapeutic strategies inclu...

This resource contains two complete, exam‑ready essays written under timed conditions for the Immunology in Health & Disease module (University of Sussex, Third Year). Essay 1: Comparison of Type I and Type III hypersensitivity reactions with clinical case studies. Includes detailed analysis of two patients (Ava and Noah), with blood test results integrated in text form. Explains diagnostic reasoning, immunological mechanisms (IgE vs IgG, mast cells vs immune complexes), and clinical outcomes...

This comprehensive study resource covers Glioblastoma Multiforme (GBM) in detail, designed for Semester 5 medical/biotech students and anyone preparing for exams in oncology, neuroscience, or pathology. What’s inside: Complete lecture notes (Etiology, epidemiology, risk factors, glial cell types, WHO grading, molecular subtypes, signaling pathways, treatment options); Mechanistic depth (Clear explanations of temozolomide (TMZ) action, MGMT resistance, and DNA repair pathways); Targeted ther...

This document provides a comprehensive study resource on breast cancer and glioblastoma signaling, designed for semester-level coursework and exam preparation. It covers: Epidemiology & statistics (global and UK incidence/mortality); Risk factors (modifiable and non-modifiable); Diagnosis methods (clinical, imaging, histopathology).; Breast cancer subtypes (Luminal A/B, HER2+, triple-negative); Estrogen receptor biology (ERα activation, phosphorylation sites, signaling pathways); Therapies (end...

This document is a set of structured study notes summarizing the key concepts of cancer cell metabolism, focusing on how metabolic pathways are reprogrammed to support tumor growth and survival. The notes outline core cellular metabolic pathways (glycolysis, the TCA cycle, and oxidative phosphorylation) and contrast normal cellular metabolism with the altered metabolic phenotype observed in cancer cells. The notes also describe how oncogenes and tumor suppressor genes—including HIF-1, PI3K/...