Clinical Pharmacology Guides d'étude, Notes de cours & Résumés

Histamine A chemical the body produces that causes the inflammatory response. Antihistamine Relieve the effects of histamine on body organs and structures Antihistamines Limit the release of acetylcholine, producing an anticholinergic (drying effect) In bronchioles and GI system Antihistamines Have a sedative effect on the central nervous system Histamine H2 antagonist Compete with histamine at H2 receptor sites, only H2 receptors located in the GI tract FDA OTC cough and cold products not ...

Pharma reps need a solid understanding of 3 things 1.) Anatomy 2.) Physiology 3.) Clinical pharmacology Anatomy the study of the basic structures of the body Physiology the study of how those body structures function Clinical Pharmacology study of the effects and movement of drugs in the human body How many prescriptions dispensed each year in the US? more than 3 billion the ____ recorded the earliest surviving prescriptions Babylonians Pen Tsao (Great Herbal) -recorded by the chinese and ...

Prostaglandins INFLAMMATORY RESPONSE Also have a role in the inflammatory response housekeeping actions in the tissues Prostaglandins INFLAMMATORY RESPONSE GI tract renal function, platelet aggregation consciousness and mental functions in the brain, and temperature regulation Prostaglandins INFLAMMATORY RESPONSE also cause erythma increase blood flow remove the vasoconstrictor effects of substances such as norepinephrine and angiotensin Antiinflammatory and analgesic agents ASPIRIN greater a...

Pharmacology the study of drugs and their interactions with living systems Chemical Name scientific term that describes the molecular structure of the drug Generic official name of the drug which can be marketed by any company Trade or Brand name name followed by a trademark symbol used for marketing FDA responsible for the approval of drugs in the U.S. Prescription drugs prescribed by a licensed health care provider Nurse`s Roles and Responsibilites -administer drugs -therapeutic effect -...

Hormones chemicals that are made in an organ or gland and carried through the bloodstream to another part of the body Steroids a specific chemical group of hormones that have powerful effects on cell sensitization, healimg, and development Catabolic state a state in which the body breaks down complex compounds into simple substances , caused by relative or absolute lack of insulin, insulin resistance, and impaired or insufficient target cell receptors Lipodystrophy or shrinkage and loss of fa...

Pharmacology Biomedical study of the interaction of chemical substances with living systems, including cells, tissues, and organisms. Until the end of the 19th century, most medicines came from Naturally occurring fresh plants, including herbs and flowers. Examples of natural medications used in the 19th century Morphine, marijuana, cardiac glycosides and heparin Drugs Substances or chemical agents that affect biological or living systems Drugs and physiological responses relationship Drugs ...

Absorption Drugs enter the body and pass into the circulation to reach the parts of the body they need to affect through the processes of diffusion, osmosis, and filtration. Acquired immunity A long-acting and "learned" protective response in which B lymphocytes produce antibodies that are directed against specific microorganisms; also called specific or adaptive immunity. Active immunity Acquired immunity in which the body makes antibodies to specific antigens it has encountered; can be nat...

Pharmacology study of drugs and their effects on the body The Right Patient check ID band for name and date of birth (also check for what their allergies) The Right drug Check label three times 1. Before taking the drug from the med cart 2. Before measuring it into the spill container 3. Before giving it to my patient The Right Dose -Make sure the patient is receiving the right amount of a drug before administering it -Make proper calculations - When can a dosage require change For a geriatr...

"Do people metabolize and secrete drugs the same way?" -Dr.D No, people are hyper and people are hypo. T/F some people are faster and some are slower at breaking down the antituberculosis drug T Slow Metabolism = decrease dose (& extend over time) Rapid Metabolism = increase dose (& shorten over time) We know this through blood work and blood level tests The study of doses Posology ADPIE Assess Diagnose Plan (treatment) Intervention / Implementation (educate) Evaluate T/F the medical /...

Antacids neutralize hydrochloric acid and increase gastric ph, thus inhibiting pepsin. Antiflatulents Agents that break up and prevent mucus-surrounded pockets of gas from forming in the intestine. Digestive enzymes Substances that promote digestion by acting as replacement therapy when the body's natural pancreatic enzymes are lacking, not secreted, or not properly absorbed. Disulfiram reaction Immediate and severe nausea, vomiting, and diarrhea, as well as many other adverse reactions, cau...