University College London (UCL) • Biology

Detailed exam notes compiling all important information required to get a first for the module

UCL BIOL2005 Genetic Systems: Chlamydomonas

C. elegans: characteristics, cell lineages, structure and development of vulva, saturation screening, epistasis analysis, programmed cell death, transgenesis, applications, RNAi, RNAi candidate gene screening

Arabidopsis genetics and transgenesis

Plant Genetics

Drosophila Tumourigenesis

Drosophila Mosaic Analysis - eye mutants

Gene Regulation and transgenesis

UCL BIOL2005 Genetic Systems: Phenotypic Analysis, Identification of homologous genes, mapping single candidate genes using SNPs, bulked segregant analysis - mapping zebrafish mutants nacre, colloid etc.

UCL BIOL2005 Genetic Systems: Long-range enhancer identification, Methylation state identiication, cis/trans acting regulatory elements

UCL BIOL2005 Genetic Systems - F1, F2 screen, examples of mutants

UCL BIOL2005 Genetic Systems; 3 mouse lectures - mouse genetics, mouse mutants, dominance and haploinsufficiency, F1 screen, newer screen techniques, genetics of obesity (leptin and MCR gene mutants, cloning process and identification), gene targeting techniques, GWAS study

Transgenesis in Plants

Yeast Genetics: transgenics and uses (cell cycle etc.(

Modeling metastasis using the eye of Drosophila and transgenics

Conservation genetics - extra reading with sources cited

Genome evolution - with extra reading from books

Molecular Evolution - amino acid , degenerate code etc.

Sex-specific selection - sexual dimorphism

Gene regulation evolution