ASCP Hematology Exam-MLT
A blood sample from a patient with a high titer cold agglutinin, which of the following
results can occur in the presence of a cold agglutinin?
A. increased MCV and decreased RBC
B. increased MCV and normal RBC
C. decreased MCV and increased MCHC
D. decreased MCV and RBC - ------------ANSWER: D. MCV and RBC
A characteristic morphologic feature in hemoglobin C disease is:
A. macrocytosis
B. spherocytosis
C. rouleax formation
D. target cells - ------------ANSWER: D. target cells
A common source of interference in the cyanmethehemoglobin method is:
A. hemolysis
B. very high WBC count
C. cold agglutinins
D. clumped platelets - ------------ANSWER: B. very high WBC count
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to
anti-malarial drugs, the patient experiences a severe hemolytic episode. This
episode is characterized by red cell inclusions caused by hemoglobin denaturation.
Which of the following conditions is most consistent with these findings?
A. G-6-PD deficiency
B. thalassemia major
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria - ------------ANSWER: A. G-6-PD deficiency
A patient has a high cold agglutinin titer. Automated cell counter results reveal an
elevated MCV, MCH, MCHC. Individual erythrocytes appear normal on a stained
smear, but agglutinates are noted. The appropriate course of action would be to:
A. perform the RBC, Hgb, Hct determinations using manual methods
B. perform the RBC determination by a manual method; use the automated results
for the Hgb and Hct
C. repeat the determinations using a microsample of diluted blood
, D. repeat the determinations using a prewarmed microsample of diluted blood -
------------ANSWER: D. repeat the determinations using a prewarmed microsample of
diluted blood
A patient has the following laboratory results:
RBC: 2.00 x 10^6/uL (2.00 x 10^12/L)
Hct: 24%
Hgb: 6.8 g/dL (68 g/L)
Reticulocytes: 0.8%
The mean corpuscular volume (MCV) of the patient is:
A. 35 um^3 (35 fL)
B. 83 um^3 (83 fL)
C. 120 um^3 (120 fL)
D. 150 um^3 (150 fL) - ------------ANSWER: C. 120 um^3 (120 fL)
A red blood cell about 5 um in diameter that stains bright red and shows no central
pallor is a:
A. spherocyte
B. leptocyte
C. microcyte
D. macrocyte - ------------ANSWER: A. spherocyte
A screening test for paroxysmal nocturnal hemoglobinuria is:
A. heat instability test
B. sucrose hemolysis
C. osmotic fragility
D. dithionite solubility - ------------ANSWER: B. sucrose hemolysis
After removal of red blood cells from the circulation hemoglobin is broken down into:
A. iron, porphyrin, and amino acids
B. iron, protoporphyrin, and globin
C. heme, protoporphyrin, and amino acids
D. heme, hemoseridin, and globin - ------------ANSWER: B. iron, protoporphyrin, and
globin
An enzyme deficiency assciated with moderate to sever hemolytic anemia after the
patient is exposed to certain drugs and characteristized by red cell inclusions formed
by denatured hemoglobin is:
A. lactate dehydrogenase deficiency
A blood sample from a patient with a high titer cold agglutinin, which of the following
results can occur in the presence of a cold agglutinin?
A. increased MCV and decreased RBC
B. increased MCV and normal RBC
C. decreased MCV and increased MCHC
D. decreased MCV and RBC - ------------ANSWER: D. MCV and RBC
A characteristic morphologic feature in hemoglobin C disease is:
A. macrocytosis
B. spherocytosis
C. rouleax formation
D. target cells - ------------ANSWER: D. target cells
A common source of interference in the cyanmethehemoglobin method is:
A. hemolysis
B. very high WBC count
C. cold agglutinins
D. clumped platelets - ------------ANSWER: B. very high WBC count
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to
anti-malarial drugs, the patient experiences a severe hemolytic episode. This
episode is characterized by red cell inclusions caused by hemoglobin denaturation.
Which of the following conditions is most consistent with these findings?
A. G-6-PD deficiency
B. thalassemia major
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria - ------------ANSWER: A. G-6-PD deficiency
A patient has a high cold agglutinin titer. Automated cell counter results reveal an
elevated MCV, MCH, MCHC. Individual erythrocytes appear normal on a stained
smear, but agglutinates are noted. The appropriate course of action would be to:
A. perform the RBC, Hgb, Hct determinations using manual methods
B. perform the RBC determination by a manual method; use the automated results
for the Hgb and Hct
C. repeat the determinations using a microsample of diluted blood
, D. repeat the determinations using a prewarmed microsample of diluted blood -
------------ANSWER: D. repeat the determinations using a prewarmed microsample of
diluted blood
A patient has the following laboratory results:
RBC: 2.00 x 10^6/uL (2.00 x 10^12/L)
Hct: 24%
Hgb: 6.8 g/dL (68 g/L)
Reticulocytes: 0.8%
The mean corpuscular volume (MCV) of the patient is:
A. 35 um^3 (35 fL)
B. 83 um^3 (83 fL)
C. 120 um^3 (120 fL)
D. 150 um^3 (150 fL) - ------------ANSWER: C. 120 um^3 (120 fL)
A red blood cell about 5 um in diameter that stains bright red and shows no central
pallor is a:
A. spherocyte
B. leptocyte
C. microcyte
D. macrocyte - ------------ANSWER: A. spherocyte
A screening test for paroxysmal nocturnal hemoglobinuria is:
A. heat instability test
B. sucrose hemolysis
C. osmotic fragility
D. dithionite solubility - ------------ANSWER: B. sucrose hemolysis
After removal of red blood cells from the circulation hemoglobin is broken down into:
A. iron, porphyrin, and amino acids
B. iron, protoporphyrin, and globin
C. heme, protoporphyrin, and amino acids
D. heme, hemoseridin, and globin - ------------ANSWER: B. iron, protoporphyrin, and
globin
An enzyme deficiency assciated with moderate to sever hemolytic anemia after the
patient is exposed to certain drugs and characteristized by red cell inclusions formed
by denatured hemoglobin is:
A. lactate dehydrogenase deficiency
