ONS Fundamentals of
Chemotherapy Immunotherapy
Admin with correct answers 2025
neoadjuvantvtherapyv-
vvcorrectvanswersvwhenvchemovisvusedvbeforevavprimaryvtreatmentv(surgery)vtovreducevthevsizevofv
avsolidvtumor
neoadjuvantvtherapyvisvcommonvin....v-vvcorrectvanswersvbreastvandvcolonvcancers
adjuvantvtherapyv-
vvcorrectvanswersvChemovAFTERvprimaryvtreatmentv(surgeryvorvradiation)v(commonvinvsolidvtumor
)
inductionv-vvcorrectvanswersvinitialvphasevofvhematologicvmalignanciesvsuchvasvleukemia
usuallyvinvthevhospitalvb/cvofvseriousvSEvandvpotentialvcomplicationsvfromvthevintendedvmyelosup
presion.vGoalvisvtovachievevcompletevresponse
whyvdovconsolidationv(aftervinduction)?v-
vvcorrectvanswersvtovensurevtreatmentvtakesveffectvandv↓vreoccurrence.vTreatmentvisvvitalvbcvleuk
emicvcellsvthatvarevnotvclinicallyvapparentv(viavCBC,vBMB)varevalmostvalwaysvstillvpresentvinvthevbon
evmarrow
, whatvisvmyeloablationv-vvcorrectvanswersvbonevmarrowvisvobliteratedvbyvchemovorvradiation
whyvdovmyeloablationv-
vvcorrectvanswersvtovpreparevforvperipheralvbloodvstemvcellvtransplantvorvbonevmarrowvtransplant
myeloablationvisvoftenvusedvtovtreatv-
vvcorrectvanswersvbloodvmalignanciesvsuchvasvleukemiavorvlymphoma
True/Falsev-vcombinationvtherapyvhasvbeenvshownvtovincreasevsurvivalvovervmonotherapyv-
vvcorrectvanswersvTRUE,vbutvMOAvisvnotvfullyvunderstoodv(Olsen,v2019)
reasonsvcombovchemovtherapyvthoughtvtovworkvbetterv-vvcorrectvanswersv1v-
v↓vlikelihoodvofvdrugvresistancevbcvdiffvMOAvinvdiffvdrugsv
2 v-
vcancervcellsvusuallyvheterogeneous;vdiffvMOAvofvchemosv↑amountvofvcancervcellsvkilledvatvonevti
me
3 v-
vmultiplevchemosvprovidevsynergisticveffectv(onevdrugvhelpsvanothervworkvbetter)v[leucovorinvandv
5-fluorouracilvtreatingvcolonvcancer]v[leucovorinvincreasesvdeadlyveffectvthatv5-
fluorouracilvhasvonvcancer;vcytotoxicityvisvpotentiated]
howvtovmeasurevresponsevtovtreatmentv-vvcorrectvanswersv-vsurgicalvexam/visualvinspection
-vimagingv(CT,vPET)
-vserumvbiomarkersv(e.g.vCAv15-3vforvbreastvcancer)
classificationsvofvtumorvresponse:vwhatvisvcompletevresponse?v-
vvcorrectvanswersvnovidentifiblevcancervpresencevthroughvs/svforvatvleastvonevmonthvorvlonger
Chemotherapy Immunotherapy
Admin with correct answers 2025
neoadjuvantvtherapyv-
vvcorrectvanswersvwhenvchemovisvusedvbeforevavprimaryvtreatmentv(surgery)vtovreducevthevsizevofv
avsolidvtumor
neoadjuvantvtherapyvisvcommonvin....v-vvcorrectvanswersvbreastvandvcolonvcancers
adjuvantvtherapyv-
vvcorrectvanswersvChemovAFTERvprimaryvtreatmentv(surgeryvorvradiation)v(commonvinvsolidvtumor
)
inductionv-vvcorrectvanswersvinitialvphasevofvhematologicvmalignanciesvsuchvasvleukemia
usuallyvinvthevhospitalvb/cvofvseriousvSEvandvpotentialvcomplicationsvfromvthevintendedvmyelosup
presion.vGoalvisvtovachievevcompletevresponse
whyvdovconsolidationv(aftervinduction)?v-
vvcorrectvanswersvtovensurevtreatmentvtakesveffectvandv↓vreoccurrence.vTreatmentvisvvitalvbcvleuk
emicvcellsvthatvarevnotvclinicallyvapparentv(viavCBC,vBMB)varevalmostvalwaysvstillvpresentvinvthevbon
evmarrow
, whatvisvmyeloablationv-vvcorrectvanswersvbonevmarrowvisvobliteratedvbyvchemovorvradiation
whyvdovmyeloablationv-
vvcorrectvanswersvtovpreparevforvperipheralvbloodvstemvcellvtransplantvorvbonevmarrowvtransplant
myeloablationvisvoftenvusedvtovtreatv-
vvcorrectvanswersvbloodvmalignanciesvsuchvasvleukemiavorvlymphoma
True/Falsev-vcombinationvtherapyvhasvbeenvshownvtovincreasevsurvivalvovervmonotherapyv-
vvcorrectvanswersvTRUE,vbutvMOAvisvnotvfullyvunderstoodv(Olsen,v2019)
reasonsvcombovchemovtherapyvthoughtvtovworkvbetterv-vvcorrectvanswersv1v-
v↓vlikelihoodvofvdrugvresistancevbcvdiffvMOAvinvdiffvdrugsv
2 v-
vcancervcellsvusuallyvheterogeneous;vdiffvMOAvofvchemosv↑amountvofvcancervcellsvkilledvatvonevti
me
3 v-
vmultiplevchemosvprovidevsynergisticveffectv(onevdrugvhelpsvanothervworkvbetter)v[leucovorinvandv
5-fluorouracilvtreatingvcolonvcancer]v[leucovorinvincreasesvdeadlyveffectvthatv5-
fluorouracilvhasvonvcancer;vcytotoxicityvisvpotentiated]
howvtovmeasurevresponsevtovtreatmentv-vvcorrectvanswersv-vsurgicalvexam/visualvinspection
-vimagingv(CT,vPET)
-vserumvbiomarkersv(e.g.vCAv15-3vforvbreastvcancer)
classificationsvofvtumorvresponse:vwhatvisvcompletevresponse?v-
vvcorrectvanswersvnovidentifiblevcancervpresencevthroughvs/svforvatvleastvonevmonthvorvlonger
