Psychopharmacology
& Psychopathology
SOW-PSB3BC16E
Part 1: Principles of psychopharmacology
Lecture 2: Modes of communication
Hanneke den Ouden
, Neurons use chemicals to communicate
the ones we give
,g÷ É÷¥±
""""
Behavioral systems
Circuits
Neurons
]
these are the main
excitatory and
Mono-aminen
Synapses mono amine
-
inhibitory neuro
-
transmitters
Molecules Amino acids
↓
3
they are mini blocks
OF protein
, Amino acid neurotransmitters: Excitation and inhibition:
Very similar molecules, opposite effects!
-
↓
GABA
C
more -
inhibition
> if it binds to a neuron,
it is
going to depress
action potential in that
↑
neuron and make it Less Very
likely that the neuron is similar
going to fire an action ''
in structure
potential .
+
↓
Glutamate more +
excitation
↳ more likely
4
↳ either an action
is released
potential
or not .
, Glutamate: excitation
Acts at virtually all neurons in the brain
a) Cortico - brainstem
b) Cortico - striatal
c) Thalamo - cortical
d) Cortico - thalamic
e) Cortico - cortical
→
Glutamate
everywhere
is .
→
5 Glutamate pathways are the motorways of
the brain → .
where info travels
.
& Psychopathology
SOW-PSB3BC16E
Part 1: Principles of psychopharmacology
Lecture 2: Modes of communication
Hanneke den Ouden
, Neurons use chemicals to communicate
the ones we give
,g÷ É÷¥±
""""
Behavioral systems
Circuits
Neurons
]
these are the main
excitatory and
Mono-aminen
Synapses mono amine
-
inhibitory neuro
-
transmitters
Molecules Amino acids
↓
3
they are mini blocks
OF protein
, Amino acid neurotransmitters: Excitation and inhibition:
Very similar molecules, opposite effects!
-
↓
GABA
C
more -
inhibition
> if it binds to a neuron,
it is
going to depress
action potential in that
↑
neuron and make it Less Very
likely that the neuron is similar
going to fire an action ''
in structure
potential .
+
↓
Glutamate more +
excitation
↳ more likely
4
↳ either an action
is released
potential
or not .
, Glutamate: excitation
Acts at virtually all neurons in the brain
a) Cortico - brainstem
b) Cortico - striatal
c) Thalamo - cortical
d) Cortico - thalamic
e) Cortico - cortical
→
Glutamate
everywhere
is .
→
5 Glutamate pathways are the motorways of
the brain → .
where info travels
.
