BS1006
NANYANG TECHNOLOGICAL UNIVERSITY
SEMESTER 2 MIDTERM QUIZZ 2022-2023
BS1006 Genetics and Genomics
March 2022 Time Allowed: 2 hours
INSTRUCTIONS
1. This
paper contains TVENTY FIVE (25) questions and SIX (6) pages.
2.
Each question has a SINGLE correct answer (2 marks each).
3. Answer all questions.
4. All answers are to be written in the ANSWER SHEET provided.
1. John and Jane have a child who was diagnosed with cystic fibrosis, an autosomal
recessive disease. If John and Jane have another child, what is the likelihood that their
second child will be also affected?
A. 100%
B. 99.99% Aa x Aa
50%
0 25% AA Ad Aa
0%
2. is a trait that appears genetic, but it is NOT.
A. Penetrance
B. Epistasis
Mutation
0
E. Pleiotropy
3. Aneuploidy is generated by of chromosomes during meiosis.
A. gene dosage
B. semisterility
:
E. mosaic
sister
A brother of a twin sister has a particular genetic trait that his siter does NOT have.
and grandfather were also affected by the trait but NOT his mother or
His father
grandmother. Similarly, NONE of his aunties or grand aunties ever showed signs of
this trait. What type of allele is most likely being inherited here?
A. autosomal recessive
B. autosomal dominant
C. X-linked recessive
D. Mitochondria-linked
Y-linked
This study source was downloaded by 100000899606070 from CourseHero.com on 02-21-2026 13:05:36 GMT -06:00
https://www.coursehero.com/file/225936122/BS1006-Midterms-2021-2022pdf/
, BS1006
human geneome based on
What is the order of the type of genetic mutations in the
their frequency (from more frequent to the least)?
SSR; CNV; SNP; InDel: Smithsonian translocation
0 SNP; InDel; SSR; CNV; Smithsonian translocation
• CNV; Smithsonian translocation; SNP; InDel; SSR
B. SNP; CNV; InDel; SSR; Smithsonian translocation
E.) SNP; InDel; SSR; Smithsonian translocation; CNV
are
arise by duplication events within the same species while
6.
ancestor. Both the
genes in different species that arose from the same gene in a recent
these are collectively called
A. homologs; orthologs; paralogs
B. homologs; paralogs; orthologs
C.
orthologs; homologs; paralogs
D. orthologs; paralogs; homologs
0 paralogs; orthologs; homologs
7. The pairwise map distances for four linked genes are follows: a-b = 28 m.u., b-c
as
11 m.u., c-d= m.u., b-d = 14 m.u., a-d = 14 m.u., a-c = 17 m.u. What is the order of
these four genes?
17
A. abcd 17
B. acdb
14 14
D. badc
0
(E. abcb
9. In Drosophila, genes a, b, and c are linked and in the order given. The distances are a-
b = 11.5 m.u. and b-c= 22.3 m.u. The interval exhibits 20% interference. How many
double crossovers would be recovered in a three-point cross involving a, b, and c out
of 750 progenies (round up to the closed integer)?
A. 2 observed
° " " observed
B. 10 " " " ""
§
0 .8 = 0.15 X 0.223
C.)15 expected
D. 30
observe d
E. 100 tota
9. Both parents are heterozygous at a microsatellite (SSR) locus with completely
distinct allele sets from each other. Hence, there are four different alleles amongst
the two parents at that locus. What is chance of a child being heterozygous at that
locus?
Bo
A.) 1/1
B. 1/3
C. 1/4 Ab ab
46
D. 1/2
E. 0
2
This study source was downloaded by 100000899606070 from CourseHero.com on 02-21-2026 13:05:36 GMT -06:00
https://www.coursehero.com/file/225936122/BS1006-Midterms-2021-2022pdf/
NANYANG TECHNOLOGICAL UNIVERSITY
SEMESTER 2 MIDTERM QUIZZ 2022-2023
BS1006 Genetics and Genomics
March 2022 Time Allowed: 2 hours
INSTRUCTIONS
1. This
paper contains TVENTY FIVE (25) questions and SIX (6) pages.
2.
Each question has a SINGLE correct answer (2 marks each).
3. Answer all questions.
4. All answers are to be written in the ANSWER SHEET provided.
1. John and Jane have a child who was diagnosed with cystic fibrosis, an autosomal
recessive disease. If John and Jane have another child, what is the likelihood that their
second child will be also affected?
A. 100%
B. 99.99% Aa x Aa
50%
0 25% AA Ad Aa
0%
2. is a trait that appears genetic, but it is NOT.
A. Penetrance
B. Epistasis
Mutation
0
E. Pleiotropy
3. Aneuploidy is generated by of chromosomes during meiosis.
A. gene dosage
B. semisterility
:
E. mosaic
sister
A brother of a twin sister has a particular genetic trait that his siter does NOT have.
and grandfather were also affected by the trait but NOT his mother or
His father
grandmother. Similarly, NONE of his aunties or grand aunties ever showed signs of
this trait. What type of allele is most likely being inherited here?
A. autosomal recessive
B. autosomal dominant
C. X-linked recessive
D. Mitochondria-linked
Y-linked
This study source was downloaded by 100000899606070 from CourseHero.com on 02-21-2026 13:05:36 GMT -06:00
https://www.coursehero.com/file/225936122/BS1006-Midterms-2021-2022pdf/
, BS1006
human geneome based on
What is the order of the type of genetic mutations in the
their frequency (from more frequent to the least)?
SSR; CNV; SNP; InDel: Smithsonian translocation
0 SNP; InDel; SSR; CNV; Smithsonian translocation
• CNV; Smithsonian translocation; SNP; InDel; SSR
B. SNP; CNV; InDel; SSR; Smithsonian translocation
E.) SNP; InDel; SSR; Smithsonian translocation; CNV
are
arise by duplication events within the same species while
6.
ancestor. Both the
genes in different species that arose from the same gene in a recent
these are collectively called
A. homologs; orthologs; paralogs
B. homologs; paralogs; orthologs
C.
orthologs; homologs; paralogs
D. orthologs; paralogs; homologs
0 paralogs; orthologs; homologs
7. The pairwise map distances for four linked genes are follows: a-b = 28 m.u., b-c
as
11 m.u., c-d= m.u., b-d = 14 m.u., a-d = 14 m.u., a-c = 17 m.u. What is the order of
these four genes?
17
A. abcd 17
B. acdb
14 14
D. badc
0
(E. abcb
9. In Drosophila, genes a, b, and c are linked and in the order given. The distances are a-
b = 11.5 m.u. and b-c= 22.3 m.u. The interval exhibits 20% interference. How many
double crossovers would be recovered in a three-point cross involving a, b, and c out
of 750 progenies (round up to the closed integer)?
A. 2 observed
° " " observed
B. 10 " " " ""
§
0 .8 = 0.15 X 0.223
C.)15 expected
D. 30
observe d
E. 100 tota
9. Both parents are heterozygous at a microsatellite (SSR) locus with completely
distinct allele sets from each other. Hence, there are four different alleles amongst
the two parents at that locus. What is chance of a child being heterozygous at that
locus?
Bo
A.) 1/1
B. 1/3
C. 1/4 Ab ab
46
D. 1/2
E. 0
2
This study source was downloaded by 100000899606070 from CourseHero.com on 02-21-2026 13:05:36 GMT -06:00
https://www.coursehero.com/file/225936122/BS1006-Midterms-2021-2022pdf/
