Page 1 of 28
TEST 4: NU 150 / NU150 (LATEST )
PHARMACOLOGY | QUESTIONS WITH VERIFIED
ANSWERS | 100 % CORRECT | GRADE A - GALEN
Sinemet (levodopa-carbidopa) - actions .....ANSWER.....Used to
treat Parkinson's
Dopaminergic Drug
Levodopa crosses the BBB (blood brain barrier) in small
amounts→ converted into dopamine (pleasure)
Levodopa if given with carbidopa, ↑ drug level that reaches the
brain
Carbidopa has no affect when given alone
Sinemet is the combination of Levodopa/Carbidopa.
Carbidopa-conserves more dopamine
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Levodopa-leaves more dopamine in the brain
Sinemet (levodopa-carbidopa) - Toxic ADRs .....ANSWER.....Face
or eyelid twitching
Tongue perfusion
Face grimacing
Means toxic levels of dopamine let HCP know
Sinemet (levodopa-carbidopa) - Patient Teaching
.....ANSWER.....Slow onset 2-6 weeks to become effective
Slow position changes
Red, brown, urine, sweat and saliva=normal
No high protein meals
LEAVE-odopa-leave protein meals
CARB-odopa- carb it up
Not an elimination of tremors or rigidity just DECREASES
, Page 3 of 28
Never stop abruptly
Taken lifelong
Levodopa ((Larodopa)) - actions .....ANSWER.....Used in
management of Parkinson's
Levodopa crosses the BBB in small amounts→ converted into
dopamine.
levodopa if given with carbidopa, ↑ drug level that reaches the
brain
Levodopa ((Larodopa)) - ADR .....ANSWER.....During the early
treatment with Levodopa and Carbidopa adverse reactions are
usually not seen.
GENERAL ADRs: dry mouth, dysphagia, anorexia, N/V,
abdominal pain, constipation, hand tremor, ↑headache and
dizziness.
Most serious and frequent adverse drug reaction with Levodopa:
TEST 4: NU 150 / NU150 (LATEST )
PHARMACOLOGY | QUESTIONS WITH VERIFIED
ANSWERS | 100 % CORRECT | GRADE A - GALEN
Sinemet (levodopa-carbidopa) - actions .....ANSWER.....Used to
treat Parkinson's
Dopaminergic Drug
Levodopa crosses the BBB (blood brain barrier) in small
amounts→ converted into dopamine (pleasure)
Levodopa if given with carbidopa, ↑ drug level that reaches the
brain
Carbidopa has no affect when given alone
Sinemet is the combination of Levodopa/Carbidopa.
Carbidopa-conserves more dopamine
,Page 2 of 28
Levodopa-leaves more dopamine in the brain
Sinemet (levodopa-carbidopa) - Toxic ADRs .....ANSWER.....Face
or eyelid twitching
Tongue perfusion
Face grimacing
Means toxic levels of dopamine let HCP know
Sinemet (levodopa-carbidopa) - Patient Teaching
.....ANSWER.....Slow onset 2-6 weeks to become effective
Slow position changes
Red, brown, urine, sweat and saliva=normal
No high protein meals
LEAVE-odopa-leave protein meals
CARB-odopa- carb it up
Not an elimination of tremors or rigidity just DECREASES
, Page 3 of 28
Never stop abruptly
Taken lifelong
Levodopa ((Larodopa)) - actions .....ANSWER.....Used in
management of Parkinson's
Levodopa crosses the BBB in small amounts→ converted into
dopamine.
levodopa if given with carbidopa, ↑ drug level that reaches the
brain
Levodopa ((Larodopa)) - ADR .....ANSWER.....During the early
treatment with Levodopa and Carbidopa adverse reactions are
usually not seen.
GENERAL ADRs: dry mouth, dysphagia, anorexia, N/V,
abdominal pain, constipation, hand tremor, ↑headache and
dizziness.
Most serious and frequent adverse drug reaction with Levodopa:
