BMTCN Test B questions with multiple correct answers

Transplant-related toxicity is a barrier that contributes to the under utilization for which of the following diseases? A. Non-Hodgkin lymphoma B. Acute myeloid leukemia C. Sickle cell disease D. Neuroblastoma - ANSWER-C. Sickle cell disease Despite the success of HSCT in sickle cell disease, barriers to successful HSCT include lack of a suitable donor, transplant related toxicity and immunologic graft rejection. Which of the following is a chemokine receptor that helps to regulate stem cell release into the peripheral circulation? A. CXCR4 B. CD34 C. CD14 D. CCR7 - ANSWER-A. CXCR4 CXCR4 has been identified as being important in the regulation of trafficking and homing of cells involved in hematopoiesis and the immune system. Which of the following is a disadvantage of a syngeneic transplant? A. Prolonged immunosuppression is required B. Limited supply of stem cells C. Longer time to engraftment D. Lack of graft-versu