t'18.s A;
í.,10 I ec,; LarE cel bl ol le
,l Cel - cel co m mv n\ CotR
I et ctolrsrercls directe vubindr en nd rece bor Lt{oches
lltlt\rl{ll l\\iJ\r( -lv.
GAP-luncbons ,
,konciolty
es drr cy bo * qi' i fi v [,1 t, í f iti,,t
P'ï:fr1^iobunge certerr 'tE;,\
...
.t
illllt '' wrl rn [rcr crllu larre
.<._)L_..1
l ..\.-
,
/ 6 conntyrÍ\cS = /l Lanneyon
t .) llI à conn e ICInen = ,,t hon ool *c1 nocrt iTl o\cil-'l e-n
/ 1r
,O.'/
ccnn eYtne ,/J \ q.
. a.-
. hq rlr, , I ur,,ïr
X aao tL
fte.cLor eru
' I .;).'
Jr rl soorbgn uuterocltes'
ïtrldi-r, I r,,-t
l,j" r-'lilltr c[11'rlritr r rr]cl ÈrL í.rÍl l'lultrtrti r. tli ;J
irro I ll I c-rr"1h c-iccr. r(d
= Lr-ll ul o t rÊ re- sp o ns ó n t u',r ihh thn
I
h" n'rír /
CI
lï'.ïTi': efË.;;.:ffi'
open a sluit-en =y;z3u\reRrd l'-'ÍoI:J
(
.
c+ <r ' ;)
[h vld conc rn de
o*J{-vrng
e.xLro cell r-rïotr
X prrncrpr,s v6n Cel sqnoien
6 .^/\-^/\"/^.,v\-/{rv\r
contacL oth. o' Dqfocrr(n
I r\ .4-^.é
Rcrnkeíecl\m godu r(.n
ro9 vocrh Lhv lmmu{Jnsus[Lgrn
h^,
tó'ef.' o"
;íett grotrIeicLr:r
reLepborÍtN
i-
,ài,il#*i;|'ï1ïi5il*
4 'S = ohsi:reÍÍ\de P'rctt\ erotte
rerhk.retks rontocL
nodro oÍnqr6nuies Ln e
Íasnh'er ct-tÍen kr prnpm I
"=> nret in llm,rvlOg li:,.. ,,/
Tog
Romerr
',
;'
re
O na.f^,rnnn^
Sunoob:ch 6 /!endocnen
/\.^./^/ /\./a-
= olleLn Ln trgnuu'Jrtt\stl rndocrtfnÈ s ion cl Ln qoqn
adhv ilttrt rokronsmlklrS ,) uro bloed -áoor hdt
r,r À -r
-+ heei 'snÈl. ïrchoqm
rinQ) elrkLrrsch + óemlscku
{ foroct
+e-lrkbrrsch 5i$nocL
Q xaí\. dL
E
.A
, Éêï = reayeert op sgecifreke comhrncr'hes uon lpf$g1
Ln+R.=le4
L n tR r c = dctl
L g* = dcoc\
e-enrelfde hgcrnd kon andere gLudg* hebhen op ondue Le\\.en
1. Íne mbroonreceplg.I3&
@ ronen honolen
srgnooltronsdurhe ,
- typiich rn ;LenuwsLelsel "s,gncrcr[ hornI hlnnen --r Ua- hclnq\en
opera :> Va\rlnt ctepolcrrrsohe
n(uron kon Ám Lo n3 xy^
'i I .t ; t '4.. .t. volt. verschrl = ïJq+ - hcrnabn uotleelrg
$t ê, @ rs, rl) @ a) U p 00en
\'i t I = hCTI E PoT Ë I.JT I AAL
( wo n t ko nolen tn CIrng eiu,tng o0
9qP'{u ó\ (
k)
W)
lulnrltrn. Ua - hanolrn qoqn ch rh[ + [/ _ kanolen
Mc
knnerl.r-n_
open J
=) K noqr burtttl
'= Í-epolcrtsqtre, + pobm haal SchurIt
e
@e. robdr" rre lde rsce toren
eho
= cichvsren e-niyfnr o[ r-onh^ncrol rJtd G_proLeLne
-{ Xre \cr.ttr (lrs a)
@ m ch g rece Loren
.= en{ym
crhSCh (- cr(hvrt,trb *r xre Lober (
i,s; )
q.s aoltronsduct oren
9
m Íhèh --r sccunclorre boo d s choppe-rs
,1, "rl,lj bndtnJ cp rec ep c0f Cttivqtte
6 = en xJme
---f prod u ceert mole rultn (secuncïorre
T
@ t
etwt hrnqsg1\ bsod sch oppcrs)
'=> ochvqhr qnder€
fos Iorg tu en vle eru.rrt c$t0schsche eiwq
=) Cl cHvqhg, sorns ooh
.-+ hoclren @t( cnhrbrtre
( t endrrt .r.lrj gt cle f osi orq tee rcl
fÈ \r Lït] í)., líl t-lcr-r riiticcir [i ceitlts)
GfP - h,nclende eru.ltlttn
el wf t dctt r(-f Uccr' l: b-r t ( r-i..eo r fiir
9ea ctr vèerd r.roqrdt dmr GT P .r't4' h {Á(r\0n9r
'-) GIP
- ase cr chvitrrt verwgdert Gït \GLLL,r I nuc\r!
= ( itl'' tuug
crda ber ertu tt[qn
P
b rug ;u nctie N rstn Srgn(ot -etwLKrn
tt. /. Jqevolq
J_J
stq naolbra nscl uche
= W\hl b r he clf octlvotrg
,5" urbroce [[uïcrtne sl gMnPIExen- ',1_
@ sca \d q.twr $m s clusterefi uGr\ noo\ etw
:: ór^oónl sctore-n von 5iqflcl(il rQutes
.r, Sígncr\tn lnc\, gerrdnt ,{ bcvfouts\ocrf doorlcven
@ s.r an Skelïr vle s ócl, rn lex U r e rece
"--)
'7t O=P mbrocE-\\\r\o\re Skulrien kr"rnn (n Y\rtk binclen
V',, -+ 0cvlv(\he recepsoc
w = fosl orgicrLre =t kunhen urLL bqrdur
6 SCI anst ellrn VON SI noal c6 m le-v 0 hos [6 Lno s rhde clock 5\bes
:- /hrndr
Indrng Íostorgiohe
{i Lnochwe mLrocettu\orfe sgrrcrol eru;utlu[
6. L,ronsren L Sgnool
etR srg noot ls h-d n sienb
= Wclehtv h
= ) rn o$ u leerd worcle,í
$e,reg
thv I khu rece Lcr
l* honscrrphongte cchlrole ; l* negohef feec]bcrch, procluct tnhrbeert
. urorclt ttlde Ufu SuprucluLesd zetF
L clestob rh srreflcle squenhe un L deioqecl [erct {ortr:orcJ . ÁsnQ_Ur *r -r
3' mRvA V6g< pokhung
L dfh vcn
,-i, recePror Lno$.luGue
holÍuJoarclebucl
- -:7"
sLtrlq- verschrllqn6 = l* feceobr rJq5 tra hon, endo smrn
ver tr,gd trt
l_, recepucr d estruclgsft:
recLsilr o{ge -
broylgl
Y Uhóq'o{ rnonoxrde clli S0he \l
z en Xjrne.
crnSuno prcton.5
- pyrL r,ru lLcrG. clnor ve/nÍ\lu1Lng bv I
=) e{(ecL vctn l-r0 Q c^91Ír0, gri,ond.en u^t clynamr*
ó* ncior ghaAe eierccltErr
G qchucrLng guc^ytoot cltlose
q GrP 4 CkHp
L- LG:H.P= \cq*t-coru.
cr(\rrir'-*{ \ \'Rt, ''y' - 3:ltl-igy,gt0'ctcle
vctsccLr Lo..tCLhe
sP,er
('ílaar btnlthtren {os{odl.estcotose 5
= ) Ln ;wetlLchomeft PCnrs ( !.1u,*-,",0.,'' \-..., ,. t-i,.\r.:',,)
; efeËtg
{
, GPCR.' G proRinq
coirgled rec-epLcir
tr::,.{ th."}
.Lr brncit hpo[rere < rla!<rQ^rloshcrre hofrnof\Qn = > 5i gY\(ls\
L+ = serlx-r\hne recep I i't, :; ri'I
Loren- i
,,-t1,, ir,,:ilt
,l"drvarsr ter L
i 'r{ "':!'
\'.
= ).800 qÈnÈn coclerm uoor GpCR,s L+ x cloor rncrnhrcr.,r. 't'
= c.ltv srs"e lgcrndm ,
"
L groLe
" gcirr:+ de he,Ít tu., tustgn HS.t (
o SÍï\OOh = thttrcrche iïcó elu, E
" VetAuren ,1 .l i, !rt{elrr5 i yill
rJ')rqlr Sr-ïr
" hcht (i'ru, tïr.ïr't:í\r_\tllli, ï)rrt(it"ílxg.\r
, , 5.;r i,: [t,t,jrí,i;,, )
a. "_/
urgr hrnc
lrpof lti hormoon'brnclt cp mernhmon -i dafl noor
recepLor
khv recepfor : bmrjen rn rnrclclerr ulcl helrxU\
R groot = hrr hEncl door,
llEurups. clerl brndt m mrclclerr''f
\'|
=> no brncrrng = ,^,y *'gJ"i ifftil;ïsli'ï-'ilS'ï;tiïï|f ll$:,.*'-
1 co n{ormohtveran derrnq
u.^o@-g^.n rneer noor hurt(n .r lvs vero\oqtst r^$ee
=> voríylrág vle holte (= brndrngsplcrots) '
-> Oofihechbrn;f uon 6- - erult[en
/ J\
G t'r Gf GY
= heelt em veL- = qetrondefl cron ': hq'jt'r.{t1 ..-
ívun "vErtoktt C- r.-l I {h.r{1 í-
=' brndln kq eten s
-brndtfig
ocrn mLÍn flroon => oqn membrc\cn
3. a. Luerhrns m detorl
6 lrgonci br nclt = conlorrnohe vEronr\err ng rn hrïix
-J o G- probu í\e brndt qqn recepbor
_:]'rt r) rt
r./titjr. (, tíD P \rerv0nge.n door G'fP '=) Ga r Gnx hor"nen los
u',{À L' bu bincirnq Gt P u cr een cr:n[or"
r;-tlP
het-trgh\mtQ.r rnárr<-verdnclt r(n \íIn ,)t CPJ I
i: ,'tÍ1"., \i..)í)í ,yr.-;.111, 1\ plocrtsen ("- scfro R el reg ro's )
.=t .A hon nret mur gCIed hrncïen
@ lgoncl brgll geb ondur =r holte h I' =) brnclrng nttu'dr G - prottinr
r[)\) rt,'ti;Cc.t,i r'. it ': lyf
r.lrï)1.)lr{rrri{t u:. (o-}.r., .t f-*o\ \orÀ- Strrpt)
','í i',1,..'.; ".ri =
r
a
"trrïl: men G'"r hon U\ttroqertn rn$ clown$RgÍn
o den u loot qt dose J etwa
vcrfn rng ,qï-lP
@ Grt I hcn ton l'ton qlt-n ctcbrvcrerr
33" @Proberntn-
't ao
verschr ltende
L (r" S : achuèn erdenqlCrCtL CqCloSC
ir G"Í' mhrbterl acltn/ylcrou c{dcrse
FGfq; sRrnuleren [osfotrfass C '
L+ G'lrrl3 ' shmui e-relr vro 6-ËF's hrsrne. GTp - 0,stn
í.,10 I ec,; LarE cel bl ol le
,l Cel - cel co m mv n\ CotR
I et ctolrsrercls directe vubindr en nd rece bor Lt{oches
lltlt\rl{ll l\\iJ\r( -lv.
GAP-luncbons ,
,konciolty
es drr cy bo * qi' i fi v [,1 t, í f iti,,t
P'ï:fr1^iobunge certerr 'tE;,\
...
.t
illllt '' wrl rn [rcr crllu larre
.<._)L_..1
l ..\.-
,
/ 6 conntyrÍ\cS = /l Lanneyon
t .) llI à conn e ICInen = ,,t hon ool *c1 nocrt iTl o\cil-'l e-n
/ 1r
,O.'/
ccnn eYtne ,/J \ q.
. a.-
. hq rlr, , I ur,,ïr
X aao tL
fte.cLor eru
' I .;).'
Jr rl soorbgn uuterocltes'
ïtrldi-r, I r,,-t
l,j" r-'lilltr c[11'rlritr r rr]cl ÈrL í.rÍl l'lultrtrti r. tli ;J
irro I ll I c-rr"1h c-iccr. r(d
= Lr-ll ul o t rÊ re- sp o ns ó n t u',r ihh thn
I
h" n'rír /
CI
lï'.ïTi': efË.;;.:ffi'
open a sluit-en =y;z3u\reRrd l'-'ÍoI:J
(
.
c+ <r ' ;)
[h vld conc rn de
o*J{-vrng
e.xLro cell r-rïotr
X prrncrpr,s v6n Cel sqnoien
6 .^/\-^/\"/^.,v\-/{rv\r
contacL oth. o' Dqfocrr(n
I r\ .4-^.é
Rcrnkeíecl\m godu r(.n
ro9 vocrh Lhv lmmu{Jnsus[Lgrn
h^,
tó'ef.' o"
;íett grotrIeicLr:r
reLepborÍtN
i-
,ài,il#*i;|'ï1ïi5il*
4 'S = ohsi:reÍÍ\de P'rctt\ erotte
rerhk.retks rontocL
nodro oÍnqr6nuies Ln e
Íasnh'er ct-tÍen kr prnpm I
"=> nret in llm,rvlOg li:,.. ,,/
Tog
Romerr
',
;'
re
O na.f^,rnnn^
Sunoob:ch 6 /!endocnen
/\.^./^/ /\./a-
= olleLn Ln trgnuu'Jrtt\stl rndocrtfnÈ s ion cl Ln qoqn
adhv ilttrt rokronsmlklrS ,) uro bloed -áoor hdt
r,r À -r
-+ heei 'snÈl. ïrchoqm
rinQ) elrkLrrsch + óemlscku
{ foroct
+e-lrkbrrsch 5i$nocL
Q xaí\. dL
E
.A
, Éêï = reayeert op sgecifreke comhrncr'hes uon lpf$g1
Ln+R.=le4
L n tR r c = dctl
L g* = dcoc\
e-enrelfde hgcrnd kon andere gLudg* hebhen op ondue Le\\.en
1. Íne mbroonreceplg.I3&
@ ronen honolen
srgnooltronsdurhe ,
- typiich rn ;LenuwsLelsel "s,gncrcr[ hornI hlnnen --r Ua- hclnq\en
opera :> Va\rlnt ctepolcrrrsohe
n(uron kon Ám Lo n3 xy^
'i I .t ; t '4.. .t. volt. verschrl = ïJq+ - hcrnabn uotleelrg
$t ê, @ rs, rl) @ a) U p 00en
\'i t I = hCTI E PoT Ë I.JT I AAL
( wo n t ko nolen tn CIrng eiu,tng o0
9qP'{u ó\ (
k)
W)
lulnrltrn. Ua - hanolrn qoqn ch rh[ + [/ _ kanolen
Mc
knnerl.r-n_
open J
=) K noqr burtttl
'= Í-epolcrtsqtre, + pobm haal SchurIt
e
@e. robdr" rre lde rsce toren
eho
= cichvsren e-niyfnr o[ r-onh^ncrol rJtd G_proLeLne
-{ Xre \cr.ttr (lrs a)
@ m ch g rece Loren
.= en{ym
crhSCh (- cr(hvrt,trb *r xre Lober (
i,s; )
q.s aoltronsduct oren
9
m Íhèh --r sccunclorre boo d s choppe-rs
,1, "rl,lj bndtnJ cp rec ep c0f Cttivqtte
6 = en xJme
---f prod u ceert mole rultn (secuncïorre
T
@ t
etwt hrnqsg1\ bsod sch oppcrs)
'=> ochvqhr qnder€
fos Iorg tu en vle eru.rrt c$t0schsche eiwq
=) Cl cHvqhg, sorns ooh
.-+ hoclren @t( cnhrbrtre
( t endrrt .r.lrj gt cle f osi orq tee rcl
fÈ \r Lït] í)., líl t-lcr-r riiticcir [i ceitlts)
GfP - h,nclende eru.ltlttn
el wf t dctt r(-f Uccr' l: b-r t ( r-i..eo r fiir
9ea ctr vèerd r.roqrdt dmr GT P .r't4' h {Á(r\0n9r
'-) GIP
- ase cr chvitrrt verwgdert Gït \GLLL,r I nuc\r!
= ( itl'' tuug
crda ber ertu tt[qn
P
b rug ;u nctie N rstn Srgn(ot -etwLKrn
tt. /. Jqevolq
J_J
stq naolbra nscl uche
= W\hl b r he clf octlvotrg
,5" urbroce [[uïcrtne sl gMnPIExen- ',1_
@ sca \d q.twr $m s clusterefi uGr\ noo\ etw
:: ór^oónl sctore-n von 5iqflcl(il rQutes
.r, Sígncr\tn lnc\, gerrdnt ,{ bcvfouts\ocrf doorlcven
@ s.r an Skelïr vle s ócl, rn lex U r e rece
"--)
'7t O=P mbrocE-\\\r\o\re Skulrien kr"rnn (n Y\rtk binclen
V',, -+ 0cvlv(\he recepsoc
w = fosl orgicrLre =t kunhen urLL bqrdur
6 SCI anst ellrn VON SI noal c6 m le-v 0 hos [6 Lno s rhde clock 5\bes
:- /hrndr
Indrng Íostorgiohe
{i Lnochwe mLrocettu\orfe sgrrcrol eru;utlu[
6. L,ronsren L Sgnool
etR srg noot ls h-d n sienb
= Wclehtv h
= ) rn o$ u leerd worcle,í
$e,reg
thv I khu rece Lcr
l* honscrrphongte cchlrole ; l* negohef feec]bcrch, procluct tnhrbeert
. urorclt ttlde Ufu SuprucluLesd zetF
L clestob rh srreflcle squenhe un L deioqecl [erct {ortr:orcJ . ÁsnQ_Ur *r -r
3' mRvA V6g< pokhung
L dfh vcn
,-i, recePror Lno$.luGue
holÍuJoarclebucl
- -:7"
sLtrlq- verschrllqn6 = l* feceobr rJq5 tra hon, endo smrn
ver tr,gd trt
l_, recepucr d estruclgsft:
recLsilr o{ge -
broylgl
Y Uhóq'o{ rnonoxrde clli S0he \l
z en Xjrne.
crnSuno prcton.5
- pyrL r,ru lLcrG. clnor ve/nÍ\lu1Lng bv I
=) e{(ecL vctn l-r0 Q c^91Ír0, gri,ond.en u^t clynamr*
ó* ncior ghaAe eierccltErr
G qchucrLng guc^ytoot cltlose
q GrP 4 CkHp
L- LG:H.P= \cq*t-coru.
cr(\rrir'-*{ \ \'Rt, ''y' - 3:ltl-igy,gt0'ctcle
vctsccLr Lo..tCLhe
sP,er
('ílaar btnlthtren {os{odl.estcotose 5
= ) Ln ;wetlLchomeft PCnrs ( !.1u,*-,",0.,'' \-..., ,. t-i,.\r.:',,)
; efeËtg
{
, GPCR.' G proRinq
coirgled rec-epLcir
tr::,.{ th."}
.Lr brncit hpo[rere < rla!<rQ^rloshcrre hofrnof\Qn = > 5i gY\(ls\
L+ = serlx-r\hne recep I i't, :; ri'I
Loren- i
,,-t1,, ir,,:ilt
,l"drvarsr ter L
i 'r{ "':!'
\'.
= ).800 qÈnÈn coclerm uoor GpCR,s L+ x cloor rncrnhrcr.,r. 't'
= c.ltv srs"e lgcrndm ,
"
L groLe
" gcirr:+ de he,Ít tu., tustgn HS.t (
o SÍï\OOh = thttrcrche iïcó elu, E
" VetAuren ,1 .l i, !rt{elrr5 i yill
rJ')rqlr Sr-ïr
" hcht (i'ru, tïr.ïr't:í\r_\tllli, ï)rrt(it"ílxg.\r
, , 5.;r i,: [t,t,jrí,i;,, )
a. "_/
urgr hrnc
lrpof lti hormoon'brnclt cp mernhmon -i dafl noor
recepLor
khv recepfor : bmrjen rn rnrclclerr ulcl helrxU\
R groot = hrr hEncl door,
llEurups. clerl brndt m mrclclerr''f
\'|
=> no brncrrng = ,^,y *'gJ"i ifftil;ïsli'ï-'ilS'ï;tiïï|f ll$:,.*'-
1 co n{ormohtveran derrnq
u.^o@-g^.n rneer noor hurt(n .r lvs vero\oqtst r^$ee
=> voríylrág vle holte (= brndrngsplcrots) '
-> Oofihechbrn;f uon 6- - erult[en
/ J\
G t'r Gf GY
= heelt em veL- = qetrondefl cron ': hq'jt'r.{t1 ..-
ívun "vErtoktt C- r.-l I {h.r{1 í-
=' brndln kq eten s
-brndtfig
ocrn mLÍn flroon => oqn membrc\cn
3. a. Luerhrns m detorl
6 lrgonci br nclt = conlorrnohe vEronr\err ng rn hrïix
-J o G- probu í\e brndt qqn recepbor
_:]'rt r) rt
r./titjr. (, tíD P \rerv0nge.n door G'fP '=) Ga r Gnx hor"nen los
u',{À L' bu bincirnq Gt P u cr een cr:n[or"
r;-tlP
het-trgh\mtQ.r rnárr<-verdnclt r(n \íIn ,)t CPJ I
i: ,'tÍ1"., \i..)í)í ,yr.-;.111, 1\ plocrtsen ("- scfro R el reg ro's )
.=t .A hon nret mur gCIed hrncïen
@ lgoncl brgll geb ondur =r holte h I' =) brnclrng nttu'dr G - prottinr
r[)\) rt,'ti;Cc.t,i r'. it ': lyf
r.lrï)1.)lr{rrri{t u:. (o-}.r., .t f-*o\ \orÀ- Strrpt)
','í i',1,..'.; ".ri =
r
a
"trrïl: men G'"r hon U\ttroqertn rn$ clown$RgÍn
o den u loot qt dose J etwa
vcrfn rng ,qï-lP
@ Grt I hcn ton l'ton qlt-n ctcbrvcrerr
33" @Proberntn-
't ao
verschr ltende
L (r" S : achuèn erdenqlCrCtL CqCloSC
ir G"Í' mhrbterl acltn/ylcrou c{dcrse
FGfq; sRrnuleren [osfotrfass C '
L+ G'lrrl3 ' shmui e-relr vro 6-ËF's hrsrne. GTp - 0,stn
