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Large simple trials in psychiatry: providing reliable answers to important clinical questions
Large simple trials in psychiatry
Large simple trials in psychiatry
THE LIMITATIONS OF REGULATORY TRIALS FOR CLINICAL DECISION-MAKING Because the design of these trials is based on a negotiation between regulators and industry, these trials often have substantial limitations for answering clinical questions in the real world and, hence, limited clinical credibility. Nonetheless, when they are the only randomised evidence available, they will often be used to answer clinical questions for which they were not designed. For example, evidence-based clinical...
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