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Chronic Kidney Disease (CKD) - H&H IV Final Exam Practice Questions and Answers latest update. CKD is defined as a GFR ____________ - n Ans <60 mL/min Qs The two leading causes of CKD are vascular disease and ____________ - n Ans diabetes mellitus Qs As the GFR declines the serum creatinine and BUN levels ____________ - n Ans increase Qs In the early stages the kidneys are unable to concentrate urine resulting in ____________ - n Ans polyuria