GMS 6474: Problem Sets UPDATED Study
Guide QUESTIONS AND CORRECT
ANSWERS
During contraction muscle fibers fatigue at different rates. Type 1 fibers fatigue
______ due to their ______ oxidative capacity.
last, low
last, high
first, low
first, high - CORRECT ANSWERS last, high
The motor neuron releases this neurotransmitter into the post-synaptic cleft of
the neuromuscular junction to invoke an end-plate potential.
Acetylcholine
Potassium
Nicotine
Calcium - CORRECT ANSWERS Acetylcholine
What is the role of Titan within muscle?
It allows for the rapid depolarization of the muscle cell
It slows the electrical conduction through muscle cells
It tethers myosin filaments to the Z-line
,It binds collagen. filaments to the M line
It sequesters Ca++ within the muscle cell - CORRECT ANSWERS It
tethers myosin filaments to the Z-line
In skeletal muscle, when there is maximal load, the velocity of contraction
equals 0. This is considered what type of contraction?
Isotonic
Isometric
Lengthening
Shortening - CORRECT ANSWERS Isometric
Duchenne Muscular Dystrophy (DMD) is characterized by the complete loss of
which of the following muscle proteins?
Dystrophin
Actin
Myosin
Nebulin
Serca - CORRECT ANSWERS Dystrophin
With respect to muscle physiology, after binding, the myosin pulls on actin
towards the M line and supersedes it. This causes the release of Pi as filaments
are pulled together and move towards the H zone, which results in contraction
of the muscle. Which of the following best describes this step of contraction?
Dissociation
Activation
, Termination
Power Stoke
Binding - CORRECT ANSWERS Power Stoke
Cardiac muscle acts as a syncytium due to the presence of ________ and
_________ found in Intercalated Disks
Desmosomes, gap junctions
mitochondria, dyad
sarcomeres, dyad
t-tubules, sarcoplasmic reticulum - CORRECT ANSWERS
Desmosomes, gap junctions
What do smooth muscle fibers lack?
Tropmyosin
Troponins
Actin Filaments
Myosin Filaments - CORRECT ANSWERS Troponins
Calcium is released and sequestered differently in Skeletal and Cardiac muscles.
What is one physiological relevance of cardiac muscle calcium handling?
Calsequestrin prevents tetany
Large Calcium stores in the SR allows for full contraction once activated
Relies on Calcium Induced
Guide QUESTIONS AND CORRECT
ANSWERS
During contraction muscle fibers fatigue at different rates. Type 1 fibers fatigue
______ due to their ______ oxidative capacity.
last, low
last, high
first, low
first, high - CORRECT ANSWERS last, high
The motor neuron releases this neurotransmitter into the post-synaptic cleft of
the neuromuscular junction to invoke an end-plate potential.
Acetylcholine
Potassium
Nicotine
Calcium - CORRECT ANSWERS Acetylcholine
What is the role of Titan within muscle?
It allows for the rapid depolarization of the muscle cell
It slows the electrical conduction through muscle cells
It tethers myosin filaments to the Z-line
,It binds collagen. filaments to the M line
It sequesters Ca++ within the muscle cell - CORRECT ANSWERS It
tethers myosin filaments to the Z-line
In skeletal muscle, when there is maximal load, the velocity of contraction
equals 0. This is considered what type of contraction?
Isotonic
Isometric
Lengthening
Shortening - CORRECT ANSWERS Isometric
Duchenne Muscular Dystrophy (DMD) is characterized by the complete loss of
which of the following muscle proteins?
Dystrophin
Actin
Myosin
Nebulin
Serca - CORRECT ANSWERS Dystrophin
With respect to muscle physiology, after binding, the myosin pulls on actin
towards the M line and supersedes it. This causes the release of Pi as filaments
are pulled together and move towards the H zone, which results in contraction
of the muscle. Which of the following best describes this step of contraction?
Dissociation
Activation
, Termination
Power Stoke
Binding - CORRECT ANSWERS Power Stoke
Cardiac muscle acts as a syncytium due to the presence of ________ and
_________ found in Intercalated Disks
Desmosomes, gap junctions
mitochondria, dyad
sarcomeres, dyad
t-tubules, sarcoplasmic reticulum - CORRECT ANSWERS
Desmosomes, gap junctions
What do smooth muscle fibers lack?
Tropmyosin
Troponins
Actin Filaments
Myosin Filaments - CORRECT ANSWERS Troponins
Calcium is released and sequestered differently in Skeletal and Cardiac muscles.
What is one physiological relevance of cardiac muscle calcium handling?
Calsequestrin prevents tetany
Large Calcium stores in the SR allows for full contraction once activated
Relies on Calcium Induced
