NR 293 Advanced pharmacology ROK Exam 1: Week 3 (Chapters on Exam 1 are: 2, 38, 39, 40, 42, 10, 12, 14, 16, & 44)

Review of Knowledge (ROK): Pharmacology NR291 Course NR293 Exam Exam 1: Week 3 (Chapters on Exam 1 are: 2, 38, 39, 40, 42, 10, 12, 14, 16, & 44) Purpose The Review of Knowledge (ROK) focuses on course outcomes, unit outcomes and key concepts to enhance student success on exams. Use this document as a focused guide for study in conjunction with assigned readings, PowerPoint presentations, and other course resources. Supplement this document by outlining your own notes from the textbook chapters and place your expanded more detailed notes in the Student Notes column. This document should NOT be used as a substitute for completing the assigned readings. Key Concepts Chapters Student Notes Pharmacologic Principles Chapter 2 Identify the 4 phases of pharmacokinetics, and explain briefly what occurs in each phase. 1. Absorption (p. 22-25) 2. Distribution (p.26) 3. Metabolism (p.27) 4. Excretion (p. 27-28) The half-life of a drug is the time required for one-half (50%) of a given drug to be removed from the body. It is a measure of the rate at which the drug is eliminated from the body. For instance, if the peak level of a particular drug is 100 mg/L & the measured drug level is 50 mg/L in 8 hours, then the estimated half-life of that drug is 8 hours. (Lilley, Collins, & Snyder, 2014, p. 28) Fill in the boxes: Half- life is 3 hours 3 hours 6 hours 9 hours 12 hours Drug X dose 200 mg 100 50 25 12.5 Drug X dose 500 mg 250 125 62.5 31.25 Route of Administration: The parenteral route is the fastest route by which a drug can be absorbed, followed by the enteral and topical routes. Parenteral is a general term meaning any route of administration other than the GI tract. It most commonly refers to injection. Intravenous injection delivers the drug directly into the circulation, where it is distributed with the blood throughout the body. Drugs given by intramuscular injection and subcutaneous injection are absorbed more slowly than those given intravenously.