Which family of enzymes catalyzes the majority of phase I drug metabolism?
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CYPs
Assuming the same lipophilicity and that all are neutrally charged (in reality these are
horrible assumptions), which drug would you expect to have the best membrane
permeability?
Give this one a try later!
Tylenol (smallest)
, Imagine a drug with kEL = 1.2/hr, clearance = 14.4 L/hr, and Vd = 12 L/kg. In order to
achieve a steady-state plasma concentration of 2 mg/L, how large should each
maintenance dose be if a 30 kg patient is going to take an oral dose every 12 hours?
Assume 100% bioavailability and first-order metabolism.
Give this one a try later!
346 mg
After a single dose, a drug's concentration in the plasma is measured to be 10 mg/L.
After one hour, the plasma concentration is measured to be 5 mg/L. How many hours
(after the initial dose is given) will it take for the plasma concentration to reach 0.02
mg/L, assuming first-order metabolism?
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9
Through which route is warfarin usually administered?
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Oral
After a single dose, a drug's concentration in the plasma is measured to be 10 mg/L.
After one hour, the plasma concentration is measured to be 5 mg/L. Two hours after
Give this one a try later!
CYPs
Assuming the same lipophilicity and that all are neutrally charged (in reality these are
horrible assumptions), which drug would you expect to have the best membrane
permeability?
Give this one a try later!
Tylenol (smallest)
, Imagine a drug with kEL = 1.2/hr, clearance = 14.4 L/hr, and Vd = 12 L/kg. In order to
achieve a steady-state plasma concentration of 2 mg/L, how large should each
maintenance dose be if a 30 kg patient is going to take an oral dose every 12 hours?
Assume 100% bioavailability and first-order metabolism.
Give this one a try later!
346 mg
After a single dose, a drug's concentration in the plasma is measured to be 10 mg/L.
After one hour, the plasma concentration is measured to be 5 mg/L. How many hours
(after the initial dose is given) will it take for the plasma concentration to reach 0.02
mg/L, assuming first-order metabolism?
Give this one a try later!
9
Through which route is warfarin usually administered?
Give this one a try later!
Oral
After a single dose, a drug's concentration in the plasma is measured to be 10 mg/L.
After one hour, the plasma concentration is measured to be 5 mg/L. Two hours after
