MDSs and MPDs- Questions and Answers
1. Chronic Myeloge- young adults, increased WBC, left shift, increased eos and basos, less than 20%
nous Leukemia blasts,BCR/ABL, no toxic changes
(CML)
2. Chronic Lympho- elderly, increased WBCs, malignant lymphocytes, scant blue cytoplasm, soccer
cytic Leukemia ballchromatin pattern, smudge cells, NO blasts
(CLL)
3. Paroxysmal Noc- complement mediated lysis, dark urine in the morning, Sucrose water test/Ham's
turnal Hemoglo- AcidSerum test, may lead to aplastic anemia or AML, now diagnosed by flow
binuria (PNH) cytometry
4. Multiple Myelo- increased plasma cells, rouleaux, increased IgG, increased ESR, Bence Jones pro-
ma (MM) teinuria,serum and urine protein electrophoresis, must do Bone marrow studies
to diagnose
5. Waldenström malignant clone of plasmacytoid lymphs, increased IgM,SIA Water test - inverted
macroglobuline- parachute
mia (WM)
6. Acute mostly in children, >30% blasts, no auer rods
Lymphoblastic
Leukemia (ALL)
7. Acute Myeloblas- middle aged, >30% blasts, auer rods may be present
tic Leukemia
(AML)
8. Hemolytic Ure- bloody diarrhea, schistocytes and thrombocytopenia following e. coli 0157 H7
mic Syndrome infection,children and elderly
(HUS)
9. elderly men, hairy cells
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1. Chronic Myeloge- young adults, increased WBC, left shift, increased eos and basos, less than 20%
nous Leukemia blasts,BCR/ABL, no toxic changes
(CML)
2. Chronic Lympho- elderly, increased WBCs, malignant lymphocytes, scant blue cytoplasm, soccer
cytic Leukemia ballchromatin pattern, smudge cells, NO blasts
(CLL)
3. Paroxysmal Noc- complement mediated lysis, dark urine in the morning, Sucrose water test/Ham's
turnal Hemoglo- AcidSerum test, may lead to aplastic anemia or AML, now diagnosed by flow
binuria (PNH) cytometry
4. Multiple Myelo- increased plasma cells, rouleaux, increased IgG, increased ESR, Bence Jones pro-
ma (MM) teinuria,serum and urine protein electrophoresis, must do Bone marrow studies
to diagnose
5. Waldenström malignant clone of plasmacytoid lymphs, increased IgM,SIA Water test - inverted
macroglobuline- parachute
mia (WM)
6. Acute mostly in children, >30% blasts, no auer rods
Lymphoblastic
Leukemia (ALL)
7. Acute Myeloblas- middle aged, >30% blasts, auer rods may be present
tic Leukemia
(AML)
8. Hemolytic Ure- bloody diarrhea, schistocytes and thrombocytopenia following e. coli 0157 H7
mic Syndrome infection,children and elderly
(HUS)
9. elderly men, hairy cells
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