Biochemistry Overview of Metabolism Lecture Notes

OverviewMetabolism
Metabolism chemical change
9 G
sumChem changes convert Nutrients E P 1kH
viaspecific Chemintermediates
I
loos enzymatic rims organized into discretepathways 6
gg
MetabolicDiversity Boggy
evolution
basioret met pathways common all life glycolysis
ancient
anaerobicbefore02
Alternate pathways Diversity
organisms classified obtain
carbon e s
Energy
Autotrophs Heterotrophs phototrophs chemotrophs
singleogaera sources run
002
many
OrganicMolecules
organiomolecules




EnergyFlow in Biosphere
solarenergy Pro
pn gjucote yreactants
gmaaffoteh.by M T useglucose
photoautotrophic Heterotrophic as fuel q
cells cells buildingblock
uremnlight tooyntherige
to synthesize
glucosefrom
cost H2O reactants
Hoff I products
ambiomolecule



Anabolism Catabolism
building breaking
metabolism
Generate E h sure captured
chemical E

I
vdptitfalfesses
Mbinotmhoeinkuies

catabolism Anabolism

Bondbreakage_release energy

I

, catabolism oxidation
Breakdown of complexnutrients
carbohydrates Lacticacid
lipids CO2
proteins urea
NH 3
ethanol

Exergonic spontaneous DG a products a reactants
Oxidative
Degradation loss e
e taken from arbitrate NADT and NADPt coenzymes
will bereduced gain e from rib
I
ATP a andNADPH
NADH
adenosinetriphosphate Utedin biosyntheticrunsanabolism
oxidation of MADH to MADT
Coupled to ATPtynthetis
needs E from ATP
3stages Aerobic catabolim
nutrients degraded into buildingblocks
proteins s AA
s Fattyacids
lipids8 glycerol
carb s glucose


buildingblocks furtherdegraded into limited tet
Metabolic intermediates
AA sauto acids s pyruvate acetylCoA
glycerol glucose pyruvate
fatty acids s
acetylCoA
s acetylCoA
pyruvate
commonendproduct catabolism

AcetylCoA converted to waste via citric acidcycle
oxydatinephosphorylation
AcetylCoA CO2 t H2O