COMLEX LEVEL 1 ACTUAL EXAM PAPER 2026
QUESTIONS WITH ANSWERS GRADED A+
◉ IVDU causes rapid onset bacterial endocarditis (what bacteria) .
Answer: Staph aureus
-Tricuspid valve most commonly affected
-"Tricuspid valve endocarditis"
◉ Most common cause of Toxic Shock Syndrome . Answer: Staph
aureus
-Hx of nasal packing or tampon in for too long
◉ Treatment for Staph aureus (MSSA) . Answer: Nafcillin
-"Naf for Staph"
◉ Pnemonic for Cornybacterium diptheria . Answer: "ABCDEFG"
-ADP-ribosylation, Beta-prophage, Corynebacterium, Diptheriae,
Elongation Factor 2, Granules
◉ Virulence factor for Gram (-) rods . Answer: LPS
-Lipopolysaccharide
,◉ Pt with history of dental trauma or dental caries that develops cardiac
problems . Answer: 1) Strep viridans
2) Strep mutans
3) Strep sanguineous
◉ Two times for Periodic Acid-Schiff (PAS) . Answer: 1) Whipple's
Disease
2) Alpha1-antitrypsin deficiency
◉ Peptidoglycan (cell wall) synthesis is is inhibited by: . Answer: -Beta
lactams
◉ Community Acquired MRSA . Answer: -Pt will have recurrent
cellulitis or boils
-Contact sports, prisoners/inmates, military recruits
-Tx: Trimethoprim-sulfamethoxazole
◉ Most important virulence factor for Strep pyogenes . Answer: M
protein
-Prevents phagocytosis and complement activation
-Molecular mimicry
, ◉ Rheumatic Fever . Answer: -Strep pyogenes
-JONES criteria
◉ Thick, golden colored crust . Answer: Impetigo
-Strep pyogenes
-Tx: topical mupirocin
◉ Erysipelas . Answer: -Due to Strep pyogenes
-Redness/swelling of an extremity w/ bull and enlarged lymph nodes
◉ Scarlet Fever . Answer: -Strep pyogenes
-Pyrogenic exotoxin
-1) Strawberry tongue, 2) Sandpaper rash
◉ Necrotizing fasciitis w/ Strep progenies infection . Answer: -Exotoxin
B
-Pain out of proportion to PE findings
◉ Blood cultures in patients with toxic shock syndrome are: . Answer:
NEGATIVE in *Staph* SSS
◉ Hot tub folliculitis
QUESTIONS WITH ANSWERS GRADED A+
◉ IVDU causes rapid onset bacterial endocarditis (what bacteria) .
Answer: Staph aureus
-Tricuspid valve most commonly affected
-"Tricuspid valve endocarditis"
◉ Most common cause of Toxic Shock Syndrome . Answer: Staph
aureus
-Hx of nasal packing or tampon in for too long
◉ Treatment for Staph aureus (MSSA) . Answer: Nafcillin
-"Naf for Staph"
◉ Pnemonic for Cornybacterium diptheria . Answer: "ABCDEFG"
-ADP-ribosylation, Beta-prophage, Corynebacterium, Diptheriae,
Elongation Factor 2, Granules
◉ Virulence factor for Gram (-) rods . Answer: LPS
-Lipopolysaccharide
,◉ Pt with history of dental trauma or dental caries that develops cardiac
problems . Answer: 1) Strep viridans
2) Strep mutans
3) Strep sanguineous
◉ Two times for Periodic Acid-Schiff (PAS) . Answer: 1) Whipple's
Disease
2) Alpha1-antitrypsin deficiency
◉ Peptidoglycan (cell wall) synthesis is is inhibited by: . Answer: -Beta
lactams
◉ Community Acquired MRSA . Answer: -Pt will have recurrent
cellulitis or boils
-Contact sports, prisoners/inmates, military recruits
-Tx: Trimethoprim-sulfamethoxazole
◉ Most important virulence factor for Strep pyogenes . Answer: M
protein
-Prevents phagocytosis and complement activation
-Molecular mimicry
, ◉ Rheumatic Fever . Answer: -Strep pyogenes
-JONES criteria
◉ Thick, golden colored crust . Answer: Impetigo
-Strep pyogenes
-Tx: topical mupirocin
◉ Erysipelas . Answer: -Due to Strep pyogenes
-Redness/swelling of an extremity w/ bull and enlarged lymph nodes
◉ Scarlet Fever . Answer: -Strep pyogenes
-Pyrogenic exotoxin
-1) Strawberry tongue, 2) Sandpaper rash
◉ Necrotizing fasciitis w/ Strep progenies infection . Answer: -Exotoxin
B
-Pain out of proportion to PE findings
◉ Blood cultures in patients with toxic shock syndrome are: . Answer:
NEGATIVE in *Staph* SSS
◉ Hot tub folliculitis
