KUBY IMMUNOLOGY CHAPTER 7
EXAM QUESTIONS AND ANSWERS
MHC molecules:
A. are secreted by T cells and bind and neutralize antigen in the serum
B. are membrane-bound molecules found exclusively on T cells
C. bind repeating patterns found on pathogens
D. are recognized by T cells
E. are conserved between individuals - Correct Answers -4. are recognized by T cells
How many different MHC classical class I proteins does each nucleated cell in a human
heterozygous at the MHC locus express?
A. None, only APC express class I
B. one
C. two
D. three
E. six - Correct Answers -E. six
A mutation in which part of a viral protein might allow the virus to evade the adaptive
immune response because of MHC binding?
A. a TCR constant residue
B. a residue in the transmembrane domain of an envelope protein
C. a residue in the DNA-binding domain
D. an anchor residue
E. an amino acid on the surface of the virus - Correct Answers -D. an anchor residue
Which of the following cell types would be MOST likely to express MHC class I?
, A. B cells
B. T cells
C. Dendritic cells
D. Lung epithelial
E. all of the above - Correct Answers -E. all of the above
Which of the following cell types would be LEAST likely to express MHC class II?
A. B cells
B. T cells
C. Dendritic cells
D. Thymic epithelial cells
E. Vascular endothelial cells - Correct Answers -B. T cells
MHC diversity ultimately affects the:
A. variety of peptides that bind to MHC
B. variety of BCRs that are expressed on mature B cells
C. rate of somatic hypermutation
D. number of antigen presenting cells
E. transmembrane domain - Correct Answers -A. variety of peptides that bind to MHC
The human MHC locus is one of the most polymorphic regions of the genome. What
does this mean?
A. it has the most different genes
B. there are many different alleles of these genes
C. sequence variability is low in this region
D. there are many introns in this region
E. this region is regulated by many different mechanisms - Correct Answers -B. there
are many different alleles of these genes
One way a developing fetus is protected from attack by the maternal immune system is:
EXAM QUESTIONS AND ANSWERS
MHC molecules:
A. are secreted by T cells and bind and neutralize antigen in the serum
B. are membrane-bound molecules found exclusively on T cells
C. bind repeating patterns found on pathogens
D. are recognized by T cells
E. are conserved between individuals - Correct Answers -4. are recognized by T cells
How many different MHC classical class I proteins does each nucleated cell in a human
heterozygous at the MHC locus express?
A. None, only APC express class I
B. one
C. two
D. three
E. six - Correct Answers -E. six
A mutation in which part of a viral protein might allow the virus to evade the adaptive
immune response because of MHC binding?
A. a TCR constant residue
B. a residue in the transmembrane domain of an envelope protein
C. a residue in the DNA-binding domain
D. an anchor residue
E. an amino acid on the surface of the virus - Correct Answers -D. an anchor residue
Which of the following cell types would be MOST likely to express MHC class I?
, A. B cells
B. T cells
C. Dendritic cells
D. Lung epithelial
E. all of the above - Correct Answers -E. all of the above
Which of the following cell types would be LEAST likely to express MHC class II?
A. B cells
B. T cells
C. Dendritic cells
D. Thymic epithelial cells
E. Vascular endothelial cells - Correct Answers -B. T cells
MHC diversity ultimately affects the:
A. variety of peptides that bind to MHC
B. variety of BCRs that are expressed on mature B cells
C. rate of somatic hypermutation
D. number of antigen presenting cells
E. transmembrane domain - Correct Answers -A. variety of peptides that bind to MHC
The human MHC locus is one of the most polymorphic regions of the genome. What
does this mean?
A. it has the most different genes
B. there are many different alleles of these genes
C. sequence variability is low in this region
D. there are many introns in this region
E. this region is regulated by many different mechanisms - Correct Answers -B. there
are many different alleles of these genes
One way a developing fetus is protected from attack by the maternal immune system is:
