IMMUNOLOGY TEST 1 KUBY CH1-6
QUESTIONS AND ANSWERS
Which is the best definition of "immunity"? - Correct Answers -The state of being
resistant to reinfection with a pathogen
Effectors of the humoral immune system are known as - Correct Answers -antibodies,
immunoglobulin, complement, B Cells
Which of the following cell types are lymphocytes? - Correct Answers -T cells
Which of the following is TRUE about antigens? - Correct Answers -antigens are
recognized by T cells or B cells
Which of the following classes of cell surface receptors are directly encoded in the
germline? - Correct Answers -PRR
What is the central mechanism for establishing self-tolerance? - Correct Answers -Self-
reactive T cells and B cells are killed during development.
Which of the following BEST describes chemokines? - Correct Answers -Soluble
proteins that recruit specific cells to an area
Which of the following statements BEST differentiates innate and adaptive immune
responses? - Correct Answers -Innate responses are stronger during the primary and
less important during the secondary response, while adaptive responses are less robust
during primary responses and stronger during secondary responses.
True or False? The innate and adaptive immune responses largely work independently
of one another. - Correct Answers -False
How do memory cells develop? - Correct Answers -T cells and B cells from the primary
response persist and become reactivated.
Conditions in which the immune system attacks self-antigens are known as - Correct
Answers –autoimmunity
Which family of cytokines regulates target-cell development, proliferation, or death? -
Correct Answers -Tumor Necrosis Factor family
, _______ are proteins that inhibit the activity of various cytokines. - Correct Answers -
Cytokine antagonist
Epstein-Barr virus produces an IL-10 homologue. What is the purpose of the IL-10
homologue? - Correct Answers -The IL-10 homologue binds to the cell receptor to
prevent cytokines from triggering an inflammatory response.
All blood cells in an adult human can trace their ancestry to which compartment within
the body? - Correct Answers -Bone marrow
From which of the following stem cells are DCs derived? - Correct Answers -CLP and
CMP
Which lineage of immune cells constitutes the first line of defense against an infection? -
Correct Answers -Myeloid
Which of the following cell types is responsible for the secretion of immunoglobulins? -
Correct Answers -Plasma Cell
Which of the following cell types is responsible for regulating responses against
intracellular pathogens? - Correct Answers -TH1
Which of the following cell types is responsible for regulating responses against
predominantly extracellular pathogens? - Correct Answers -TH2
Which of the following types of effector T lymphocytes is capable of inhibiting an
immune response to an antigen recognized with its T-cell receptor (TCR)? - Correct
Answers -Treg
Which of the following is NOT considered primary lymphoid tissue? - Correct Answers -
Draining Lymph node and Peyer's patch are not primary lymphoid tissue. Thymus is
primary lymphoid tissue
In mammals, T-cell development occurs in the ____________, while B-cell development
occurs predominantly in the ______________. - Correct Answers -thymus; bone
marrow
As thymocytes develop, they are classified on the basis of the state of their T-cell
receptors and which of the following? - Correct Answers -The presence of coreceptor
proteins CD4 and CD8 on their surface
Upon entering the thymus, thymocytes are classified as double __________ with regard
to coreceptor; before exiting as single-positive, naïve T cells, they pass through a period
in which they are double ________. - Correct Answers -negative; positive
QUESTIONS AND ANSWERS
Which is the best definition of "immunity"? - Correct Answers -The state of being
resistant to reinfection with a pathogen
Effectors of the humoral immune system are known as - Correct Answers -antibodies,
immunoglobulin, complement, B Cells
Which of the following cell types are lymphocytes? - Correct Answers -T cells
Which of the following is TRUE about antigens? - Correct Answers -antigens are
recognized by T cells or B cells
Which of the following classes of cell surface receptors are directly encoded in the
germline? - Correct Answers -PRR
What is the central mechanism for establishing self-tolerance? - Correct Answers -Self-
reactive T cells and B cells are killed during development.
Which of the following BEST describes chemokines? - Correct Answers -Soluble
proteins that recruit specific cells to an area
Which of the following statements BEST differentiates innate and adaptive immune
responses? - Correct Answers -Innate responses are stronger during the primary and
less important during the secondary response, while adaptive responses are less robust
during primary responses and stronger during secondary responses.
True or False? The innate and adaptive immune responses largely work independently
of one another. - Correct Answers -False
How do memory cells develop? - Correct Answers -T cells and B cells from the primary
response persist and become reactivated.
Conditions in which the immune system attacks self-antigens are known as - Correct
Answers –autoimmunity
Which family of cytokines regulates target-cell development, proliferation, or death? -
Correct Answers -Tumor Necrosis Factor family
, _______ are proteins that inhibit the activity of various cytokines. - Correct Answers -
Cytokine antagonist
Epstein-Barr virus produces an IL-10 homologue. What is the purpose of the IL-10
homologue? - Correct Answers -The IL-10 homologue binds to the cell receptor to
prevent cytokines from triggering an inflammatory response.
All blood cells in an adult human can trace their ancestry to which compartment within
the body? - Correct Answers -Bone marrow
From which of the following stem cells are DCs derived? - Correct Answers -CLP and
CMP
Which lineage of immune cells constitutes the first line of defense against an infection? -
Correct Answers -Myeloid
Which of the following cell types is responsible for the secretion of immunoglobulins? -
Correct Answers -Plasma Cell
Which of the following cell types is responsible for regulating responses against
intracellular pathogens? - Correct Answers -TH1
Which of the following cell types is responsible for regulating responses against
predominantly extracellular pathogens? - Correct Answers -TH2
Which of the following types of effector T lymphocytes is capable of inhibiting an
immune response to an antigen recognized with its T-cell receptor (TCR)? - Correct
Answers -Treg
Which of the following is NOT considered primary lymphoid tissue? - Correct Answers -
Draining Lymph node and Peyer's patch are not primary lymphoid tissue. Thymus is
primary lymphoid tissue
In mammals, T-cell development occurs in the ____________, while B-cell development
occurs predominantly in the ______________. - Correct Answers -thymus; bone
marrow
As thymocytes develop, they are classified on the basis of the state of their T-cell
receptors and which of the following? - Correct Answers -The presence of coreceptor
proteins CD4 and CD8 on their surface
Upon entering the thymus, thymocytes are classified as double __________ with regard
to coreceptor; before exiting as single-positive, naïve T cells, they pass through a period
in which they are double ________. - Correct Answers -negative; positive
