Immunology (UAMS) Exam 4 Questions and
Answers (100% Correct Answers) Already
Graded A+
Secondary immune deficiencies [ Ans: ] Abnormality due
to another disorder, infection, or treatment
Diseases associated with secondary immune deficiencies [
Ans: ] Hodgkins disease and lymphoma,
Leukemia,
Myeloma, macroglobulinemia
Infections associated with secondary immune deficiency [
Ans: ] Bacterial, protozoal, helminthic and fungal
What other conditions is associated with secondary
immune deficiency? [ Ans: ] Burns, DM, malnutrition,
surgical procedures/trauma, renal malfunction, aging and
alcoholic cirrhosis
What are the immunosuppressants associated with
Secondary immunodeficiency? [ Ans: ] Antimetabolites,
corticosteroids and radiation
What are the primary B-cell deficiencies? [ Ans: ] Transient
agammaglobulinemia of infancy,
X-linked Brutons agammaglobulinemia,
,IgA Deficiency,
Common Variable immunodeficiency
What are the cellular immunity deficiencies? [ Ans: ]
DiGeorge Anomaly,
Purine-nucleoside phosphorylase (PNP) Deficiency
What are the combined deficiencies of cellular and
humoral immunity? [ Ans: ] Severe combined
immunodeficiency (SCID),
Wiskott-Aldrich Syndrome,
Ataxia Telangiectasia
What are the oxidative metabolism disorders of neutrophil
dysfunction? [ Ans: ] Chronic Granulomatous Disease
(CGD),
Myeloperioxidase deficiency
Leukocyte adhesion molecule deficiency is an immune
deficiency under what type of WBC dysfunction? [ Ans: ]
Neutrophil
What are the sites where immune system may fail? [ Ans: ]
T Cells,
B Cells,
,Phagocytic Cells,
Complement
Regulation disruption is described as? [ Ans: ] Where a
defect in one system may cause hyper-reactivity in
another
Which immunodeficiency states are associated with
allergic or autoimmune manifestations? [ Ans: ] Partial
Immunodeficiency States
These syndromes are relatively rare (Minus IgA
Deficiency), include inherited defects of the immune
system and patients present with recurring infections [
Ans: ] Primary Immunodeficiency Syndromes
Defects in this immunity present with pyrogenic bacterial
infections of the upper and lower respiratory track
(normal amount of viral infections as normal populace) [
Ans: ] Humoral Immunity Defect
At birth there are very low levels of these
immunoglobulins [ Ans: ] IgA and IgM
At birth there are adult levels of these immunoglobulins [
Ans: ] IgG
Decrease as age progresses and maternal IgG's are
metabolized
, Genetic defects in B Cell maturation or defective T and B
cells interactions are immunodeficiencies that fall under
which type of immunodefieicy, primary or secondary? [
Ans: ] Primary
Prolonged low levels of immunoglobulins where children
have problems with infections and delay of normal Ig
levels has been attributed to poor T Cell help is a primary
immunodeficiency condition termed what? [ Ans: ]
Transient Agammaglobulinemia of infancy
This is an X-linked condition seen almost exclusively in
males where there is a lack of mature B-lymphs and all
classes of Ig where the tonsils and adenoids are small or
absent and T cells are found to be normal. [ Ans: ] X-
linked Bruton's agammaglobulinemia
In X-linked Agammaglobulinemia the development of B
Cells is blocked from the Pro-B to Pre-B stage and causes a
failure of Vh gene rearrangement due to the lack of this
enzyme [ Ans: ] Bruton tyrosine kinase
What are the differentiation factors of transient
agammaglobulinemia and x-linked Bruton's
agammaglobulinemia? [ Ans: ] Histological differences in
lymphoid tissues, (x-linked abnormal) and the persistence
beyond age 2
What is the treatment for x-linked Bruton's
Agammaglobulinemia? [ Ans: ] IM/IV Ig treatment and
copious amounts of antimicrobial agents
Answers (100% Correct Answers) Already
Graded A+
Secondary immune deficiencies [ Ans: ] Abnormality due
to another disorder, infection, or treatment
Diseases associated with secondary immune deficiencies [
Ans: ] Hodgkins disease and lymphoma,
Leukemia,
Myeloma, macroglobulinemia
Infections associated with secondary immune deficiency [
Ans: ] Bacterial, protozoal, helminthic and fungal
What other conditions is associated with secondary
immune deficiency? [ Ans: ] Burns, DM, malnutrition,
surgical procedures/trauma, renal malfunction, aging and
alcoholic cirrhosis
What are the immunosuppressants associated with
Secondary immunodeficiency? [ Ans: ] Antimetabolites,
corticosteroids and radiation
What are the primary B-cell deficiencies? [ Ans: ] Transient
agammaglobulinemia of infancy,
X-linked Brutons agammaglobulinemia,
,IgA Deficiency,
Common Variable immunodeficiency
What are the cellular immunity deficiencies? [ Ans: ]
DiGeorge Anomaly,
Purine-nucleoside phosphorylase (PNP) Deficiency
What are the combined deficiencies of cellular and
humoral immunity? [ Ans: ] Severe combined
immunodeficiency (SCID),
Wiskott-Aldrich Syndrome,
Ataxia Telangiectasia
What are the oxidative metabolism disorders of neutrophil
dysfunction? [ Ans: ] Chronic Granulomatous Disease
(CGD),
Myeloperioxidase deficiency
Leukocyte adhesion molecule deficiency is an immune
deficiency under what type of WBC dysfunction? [ Ans: ]
Neutrophil
What are the sites where immune system may fail? [ Ans: ]
T Cells,
B Cells,
,Phagocytic Cells,
Complement
Regulation disruption is described as? [ Ans: ] Where a
defect in one system may cause hyper-reactivity in
another
Which immunodeficiency states are associated with
allergic or autoimmune manifestations? [ Ans: ] Partial
Immunodeficiency States
These syndromes are relatively rare (Minus IgA
Deficiency), include inherited defects of the immune
system and patients present with recurring infections [
Ans: ] Primary Immunodeficiency Syndromes
Defects in this immunity present with pyrogenic bacterial
infections of the upper and lower respiratory track
(normal amount of viral infections as normal populace) [
Ans: ] Humoral Immunity Defect
At birth there are very low levels of these
immunoglobulins [ Ans: ] IgA and IgM
At birth there are adult levels of these immunoglobulins [
Ans: ] IgG
Decrease as age progresses and maternal IgG's are
metabolized
, Genetic defects in B Cell maturation or defective T and B
cells interactions are immunodeficiencies that fall under
which type of immunodefieicy, primary or secondary? [
Ans: ] Primary
Prolonged low levels of immunoglobulins where children
have problems with infections and delay of normal Ig
levels has been attributed to poor T Cell help is a primary
immunodeficiency condition termed what? [ Ans: ]
Transient Agammaglobulinemia of infancy
This is an X-linked condition seen almost exclusively in
males where there is a lack of mature B-lymphs and all
classes of Ig where the tonsils and adenoids are small or
absent and T cells are found to be normal. [ Ans: ] X-
linked Bruton's agammaglobulinemia
In X-linked Agammaglobulinemia the development of B
Cells is blocked from the Pro-B to Pre-B stage and causes a
failure of Vh gene rearrangement due to the lack of this
enzyme [ Ans: ] Bruton tyrosine kinase
What are the differentiation factors of transient
agammaglobulinemia and x-linked Bruton's
agammaglobulinemia? [ Ans: ] Histological differences in
lymphoid tissues, (x-linked abnormal) and the persistence
beyond age 2
What is the treatment for x-linked Bruton's
Agammaglobulinemia? [ Ans: ] IM/IV Ig treatment and
copious amounts of antimicrobial agents
