Summary NR 566 Week 4 Study Guide Chapter 25: Drugs Used in Treating Inflammatory Processes

NR 566 Week 4 Study Guide Chapter 25: Drugs Used in Treating Inflammatory Processes Pharmacodynamics: • MOA: exact MOA of NSAIDS is not known, thought to be inhibition of cyclo-oxygenase activity and prostaglandin synthesis o Inhibition of lipo-oxygenase, leukotriene synthesis, lysosomal enzyme release, neutrophil aggregation, and various cell membrane functions may also occur o May also suppress rheumatoid factor • Two cyclo-oxygenase isoenzymes have been identified: COX-1 and COX 2. COX-1: Expressed systemically and synthesized continuously so that it is present all the time in all tissues and cells, especially platelets; endothelial cells; the GI tract; and renal microvasculature, glomeruli, and collecting ducts. It has roles in homeostatic maintenance, such as platelet aggregation, the regulation of blood flow to the kidney and stomach, and the regulation of gastric acid secretion and production of protective mucus, especially in the stomach. Inhibition of these activities by NSAIDs accounts for their adverse reactions, especially on the renal and GI tracts.