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ONCC Oncology Nursing Knowledge Certification Test 2026/2027 | Updated Practice Questions & Correct Answers

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ONCC Oncology Nursing Knowledge Certification Test 2026/2027 | Updated Practice Questions & Correct Answers Which of the following cancers is associated with the development of disseminated intravascular coagulation? Mucin-secreting adenocarcinoma of the breast Nonhyperdiploid variant multiple myeloma Primary peritoneal carcinoma Acral lentiginous melanoma Mucin-secreting adenocarcinoma of the breast Answer: The incidence of disseminated intravascular coagulation is associated mostly with mucin-secreting adenocarcinomas of the prostate, lung, and breast. Reference: Kaplan, M. (Ed.). (2013). Understanding and managing oncologic emergencies: A resource for nurses (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 69. Which of the following is released into the bloodstream in the event of tumor lysis syndrome? Uric acid Sodium Magnesium Calcium Uric acid Answer: Tumor lysis syndrome is a massive, sudden release of cellular contents in to the bloodstream resulting in elevated uric acid levels. Reference: Kaplan, M. (Ed.). (2013). Understanding and managing oncologic emergencies: A resource for nurses (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 440. Which of the following classes of medication will most significantly increase the risk for the development of a cytokine-release syndrome reaction? Monoclonal antibodies Taxanes Platinum compounds Anthracyclines Monoclonal antibodies Answer: Monoclonal antibodies can cause cytokine-release syndrome. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 243. When a suspected extravasation occurs during the administration of a vesicant, the nurse must first: stop the administration of medication and fluids. remove the peripheral IV or central venous access device. aspirate the remaining vesicant from the IV tubing. notify the healthcare provider. stop the administration of medication and fluids. Answer: The first step the nurse should take when an extravasation occurs is stopping the infusion. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 217. Which of the following interventions should the nurse perform for a patient who is at risk for increased intracranial pressure? Assessing the patient's gag reflex Limiting suctioning to less than 30 seconds Keeping the patient's bed in the high Fowler's position Positioning pillows to hyperextend the neck Assessing the patient's gag reflex Answer: Increased intracranial pressure can impair the gag reflex thus affecting the patient's ability to eat and drink independently. Reference: Kaplan, M. (Ed.). (2013). Understanding and managing oncologic emergencies: A resource for nurses (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 185(t). A dexrazoxane infusion shows efficacy for treating the extravasation of: an anthracycline. a nitrosourea. an alkylating agent. a plant alkaloid. an anthracycline. Answer: Dexrazoxane is the treatment for anthracycline extravasation. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 159(t). A patient with sepsis reports hematuria and dyspnea. The laboratory values include platelets 37,000/mm3, prothrombin time 21 seconds, partial thromboplastin time 43 seconds, and fibrinogen 100 mg/dL. Which of the following is the most likely cause? Disseminated intravascular coagulation Heparin-induced thrombocytopenia Hemorrhagic cystitis Idiopathic thrombocytopenic purpura Disseminated intravascular coagulation Answer: Sepsis and infection can disrupt the clotting cascade, causing disseminated intravascular coagulation. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier, pp. 381-382. A patient with metastatic renal cell cancer is tired, confused, has not had a bowel movement in five days, and requires assistance with ambulation. Vital signs include heart rate, 55 beats per minute; respiratory rate, 18 breaths per minute; and blood pressure, 100/60 mm Hg. What is the patient most likely experiencing? Hypercalcemia Symptoms of metastasis Spinal cord compression Treatment side effects Hypercalcemia Answer: A delay in diagnosis of hypercalcemia often occurs due to nonspecificity of symptoms, which include constipation, lethargy, and confusion. The patient with hypercalcemia may also present with bradycardia due to depression of the conduction system. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1117. Which of the following medications must be available at the bedside when preparing to administer asparaginase? Epinephrine Albuterol Dopamine Sodium thiosulfate Epinephrine Answer: Epinephrine is the first line drug used to treat severe hypersensitivity reactions. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 916. A patient with lung cancer has the following laboratory results: urine sodium 92mEq/L, serum osmolality 180 mOsm/kg, and serum sodium 130mEq/L. Which of the following is the most likely cause? Syndrome of inappropriate antidiuretic hormone Systemic inflammatory response Increased intracranial pressure Idiopathic thrombocytopenia purpura Syndrome of inappropriate antidiuretic hormone Answer: Syndrome of inappropriate antidiuretic hormone is an oncologic emergency that occurs most often in patients with lung cancer. Patients will have hyponatremia with increased urinary sodium, and decreased serum osmolality. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, pp. . A patient with an astrocytoma reports headaches, a loss of balance, fatigue, and elevated blood pressure for four days and has not refilled a prescription for high-dose steriods. What is the patient most likely experiencing? Increased intracranial pressure Withdrawal Hypertensive crisis Subdural hematoma Increased intracranial pressure Answer: Drowsiness, fatigue, headache, and changes in blood pressure are symptoms of worsening increased intracranial pressure. Corticosteroids are used to decrease surrounding edema from the tumor. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1173. A patient had experienced a mild hypersensitivity reaction to the first dose of paclitaxel and now arrives for the second treatment. Which of the following interventions should the nurse perform? Slow the infusion rate of the medication. Dilute the medication in additional fluid. Administer prophylactic meperidine. Hold the medication. Slow the infusion rate of the medication. Answer: Many patients who have experienced only mild infusion reactions with the first administration of paclitaxel have tolerated subsequent doses well with a decreased rate of infusion and additional premedications. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 915. A patient with cancer receiving the 10th dose of carboplatin suddenly becomes anxious and states, "I cannot breathe." What should the nurse do first? Stop the infusion and stay with the patient. Start a second IV and give diphenhydramine 50 mg IV push. Take the patient's vital signs and call the physician. Administer oxygen and institute emergency procedures. Stop the infusion and stay with the patient. Answer: If a patient begins to experience signs and symptoms of a hypersensitivity reaction, administration of the offending agent must be stopped immediately, the IV infusion maintained, and a call for help be made, as the nurse must remain with the patient. Reference: Eggert, J. (Ed.). (2017). Cancer basics (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 536. A patient newly diagnosed with small cell lung cancer reports increased dyspnea and feels that her necklace is getting tighter around her neck. Which of the following is the most likely cause? Superior vena cava syndrome Pulmonary edema Anaphylaxis Metastasis to the thyroid Superior vena cava syndrome Answer: The most common presenting symptom of superior vena cava syndrome is facial and neck swelling. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1190. When is tissue necrosis most likely to occur after a doxorubicin extravasation? 2-3 weeks 24 hours 1- 2 months 7 days 2-3 weeks Answer: Tissue necrosis is usually evident two to three weeks after extravasation. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 157(t). What should the nurse monitor for after a patient has a paracentesis performed? Postural hypotension Hyperkalemia Hyperalbuminemia Pneumothorax Postural hypotension Answer: Removal of 2 to 3 liters of fluid via paracentesis can lead to postural hypotension due to fluid shifts. Reference: Hinkle, J., & Cheever, K. (2014). Brunner & Suddarth's Textbook of medical surgical nursing (13th ed.). Philadelphia, PA: Wolters Kluwer Health, p. 1348. Which antibody is responsible for a hypersensitivity reaction? IgE IgA IgM IgG IgE Answer: Agents cause immunoglobulin E-mediated mast cell degranulation with a release of histamine during a hypersensitivity reaction. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society. p. 163. Which of the following should be included in the initial treatment of a patient with increased intracranial pressure? Dexamethasone Labetalol Furosemide Lorazepam Dexamethasone Answer: Dexamethasone is the steroid of choice to reduce inflammation related to increased intracranial pressure due to its rapid onset. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1181. A patient with cancer is considering entering a clinical trial that compares the current standard treatment with an investigational chemotherapeutic agent. This is an example of which phase of a clinical trial? 3 4 1 2 3 Answer: Phase 3 clinical trials have a primary goal of establishing efficacy and comparing with the current standard. Reference: Eggert, J. (Ed.). (2017). Cancer basics (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 285(t). What is the shortest phase of the cell cycle? Mitosis Gap 1 Synthesis Gap 2 Mitosis Answer: Mitosis is the shortest phase of the cell's life cycle. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 25. Oligodendroglial tumors originate from cells that maintain the function of the: myelin sheath. synovial fluid. lymph. plasma. myelin sheath. Answer: Oligodendrocytes are cells that develop and maintain the myelin sheath. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1368. A squamous cell carcinoma of the esophagus is most likely to arise from the: proximal esophagus. Schatzki's ring. cricoid cartilage. abdominal esophagus. proximal esophagus. Answer: A squamous cell carcinoma of the esophagus is most likely to arise from the proximal esophagus. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1538. Which of the following techniques is most likely to support healthy communication patterns between the nurse and a patient? Eliciting feedback about preferences and experiences Establishing significant physical distance between parties Providing objective and factual information about the treatment plan Limiting questions until after all information is presented Eliciting feedback about preferences and experiences Answer: The nurse should obtain information from the patient about their understanding of concepts and their reactions in order to best promote open and honest communication. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 417(t). Upon diagnosis of an invasive ductal adenocarcinoma of the pancreas, the disease will most likely: demonstrate spread to the liver. display widespread fat necrosis. metastasize to the bone. remain confined to the primary site. demonstrate spread to the liver. Answer: Invasive ductal adenocarcinoma of the pancreas has often metastasized at the time of diagnosis. The most common site of metastasis is the liver. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1856(f). A patient has an implanted intrathecal pump for pain management. Which of the following actions best exemplifies a safe practice? Tracing the tubing from the patient to the pump Using special tubing that has injection ports Cleansing the Leur lock ports with alcohol before each use Arranging for the patient to have the pump refilled every eight months Tracing the tubing from the patient to the pump Answer: Ensuring that there are no dislodgements, kinks or issues with pump functionality by tracing the line from the patient to the pump is the safest practice when caring for a patient with an implanted intrathecal pump. Reference: Camp-Sorrell, D., & Matey, L. (Eds.). (2017). Access device standards of practice for oncology nursing. Pittsburgh, PA: Oncology Nursing Society, p. 124. A 70-year-old patient reports weight loss, abdominal pain and diarrhea that often interrupts sleep. The patient reports a brother has recently been diagnosed with prostate cancer. The nurse suspects: carcinoid syndrome. systemic inflammatory response syndrome. irritable bowel syndrome. syndrome of inappropriate antidiuretic hormone. carcinoid syndrome. Answer: Patients over the age of 66 who have a first degree relative with prostate cancer are at higher risk for the development of neuroendocrine tumors and carcinoid syndrome. Symptoms of carcinoid syndrome include pain, weight loss, and diarrhea that interrupts sleep. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 139. A patient newly diagnosed with Hodgkin lymphoma is determined to have an unfavorable prognosis through which of the following clinical findings? Absolute lymphocyte count 400/mm3 Hemoglobin 11 g/dL Involvement of two lymph nodes Presence of A symptoms Absolute lymphocyte count 400/mm3 Answer: An absolute lymphocyte count of less than 600/mm3 is an unfavorable prognostic finding for a patient with advanced Hodgkin lymphoma. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 124(t). Cancer cells differ from normal cells in their ability to: migrate to neighboring tissues and locations. divide only when new cells are needed. reside in a genetically coded area. allow contact inhibition with other cells. migrate to neighboring tissues and locations. Answer: Cancer cells are characterized by abnormal movement and uncontrolled growth. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 1. A data monitoring committee is required for which phase of a clinical trial? 3 4 1 2 3 Answer: Data monitoring committees are required for phase 3 trials to protect the safety of the trial participants. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 19. The family members of a patient who is dying disagree on the placement of a feeding tube. What action should the nurse take? Meet with the family to discuss the goals of care. Contact social work to begin the process for state guardianship. Explain that only an ethics committee can make this decision. Encourage the family to review similar cases in the media. Meet with the family to discuss the goals of care. Answer: Families often have a difficult time agreeing to goals of care for the patient. Coordinating a family meeting is a supportive structure to educate family members, answer questions, and promote communication with the professional health team. Reference: Burke, C.C. (Ed.). (2009). Psychosocial dimensions of oncology nursing care (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, pp. 20 - 21. While completing a physical assessment, the nurse observes a raised, pearly lesion on a patient's upper chest. The nurse knows this is most likely: a basal cell carcinoma. Kaposi sarcoma. leukemia cutis. a malignant melanoma. a basal cell carcinoma. Answer: Basal cell carcinoma usually shows characteristics that are slightly raised, minute, a well-defined margin that is rolled, pearly, and has telangiectasia. Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier, p. 159. A nurse assigned to care for a group of five patients provides assessment and documentation on only four of the patients, because the nurse had misread the assignment. Which of the following legal principles applies to this situation? Breach of duty Absent documentation Nonmaleficence Malpractice Breach of duty Answer: Breach of duty is defined as failing to perform one's agreement. Reference: Gullatte, M.M. (Ed.). (2011). Nursing management: Principles and practice (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 567. The use of the spouse as a translator for a non-English speaking patient is: not recommended. used to increase patient comfort levels. allowed once the spouse passes a certification test. permitted if a professional is not available. not recommended. Answer: Significant others are not recommended as translators because of role conflicts or inability to communicate complex medical terminology. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 138. Which medication in a patient's drug profile should be reported to the physician before administering cyclophosphamide? Allopurinol Metoprolol Amitriptyline Citalopram Allopurinol Answer: Cyclophosphamide is an alkylating agent that disrupts the synthesis of proteins as a cancer treatment. The concomitant use of allopurinol can increase the toxicity of the agent, particularly bone marrow depression by decreasing renal excretion. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 396(t). What is the primary purpose for providing multidisciplinary oncology care? Improving patient outcomes Delivering cost-effective services Standardizing patient communication Meeting regulatory standards Improving patient outcomes Answer: Quality of practice includes the oncology nurse participating in interprofessional teams to address outcomes and enhance factors that promote, safe, and effective patient outcomes. Reference: Brant, J.M., & Wickham, R.S. (Eds.). (2013). Statement on the scope and standards of oncology nursing practice: Generalist and advanced practice. Pittsburgh, PA: Oncology Nursing Society, p. 52. The nurse has collected and analyzed data to identify, monitor, and improve the effectiveness of oncology nursing care. Which standard of oncology nursing practice does this best exemplify? Resource utilization Patient advocacy Collaboration Collegiality Resource utilization Answer: Resource utilization requires the oncology nurse to evaluate, critique, and mobilize the most appropriate resources to maximize patient outcomes. Reference: Brant, J.M., & Wickham, R.S. (Eds.). (2013). Statement on the scope and standards of oncology nursing practice: Generalist and advanced practice. Pittsburgh, PA: Oncology Nursing Society, p. 61. Which statement made by a patient indicates the need for additional teaching regarding the coverage provided by the Family Medical Leave Act? "I know I am eligible because I am a United States citizen." "It is difficult because my time off is unpaid." "In most cases, I can take up to 12 weeks of leave." "It will enable me to care for my spouse who also has cancer." "I know I am eligible because I am a United States citizen." Answer: The Family Medical Leave Act (FMLA) of 1993 guarantees unpaid leave to care for a seriously ill spouse, son, daughter, or parent. FMLA applies to businesses with at least 50 employees. Reference: Lester, J.L., & Schmitt, P. (Eds.). (2011). Cancer rehabilitation and survivorship: Transdisciplinary approaches to personalized care. Pittsburgh, PA: Oncology Nursing Society, p. 251. An evaluation of a recently developed teaching booklet about immunotherapy indicates that the booklet has not increased a group of patients' understanding. Which of the following learning principles was most likely overlooked? Teaching is more effective when it responds to needs identified by the learner. Verbal teaching results in more effective learning. Expectations of the teacher provide the guidelines for evaluation. The method of teaching determines whether learned behavior is effective. Teaching is more effective when it responds to needs identified by the learner. Answer: It is important to assess the patients' physical, psychosocial, and emotional needs when planning and developing educational materials. Reference: Brant, J.M., & Wickham, R.S. (Eds.). (2013). Statement on the scope and standards of oncology nursing practice: Generalist and advanced practice. Pittsburgh, PA: Oncology Nursing Society, pp. 35-36. An understanding of immunology is important when developing cancer therapies because it: identifies how T cells, B cells, and natural killer cells work. explains how free radicals are eliminated from the body. influences treatment choices to maintain bone marrow function. predicts how well treatment will be tolerated. identifies how T cells, B cells, and natural killer cells work. Answer: The goals of research in immunology include the ability to understand how the immune system cells work. Reference: Eggert, J. (Ed.). (2017). Cancer basics (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 226. A true positive result from a cancer screening is indicative of which of the following? The individual: actually has cancer. does not have cancer. has cancer despite an initial negative test result. does not have cancer despite a positive test result. actually has cancer. Answer: A true positive result is a normal test for cancer in an individual who actually has cancer. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 121. The nurse manager is reviewing the policy and procedure for chemotherapy administration. How can the ASCO/ONS chemotherapy administration safety standards assist in this process? It outlines the professional responsibilities of oncology nurses in the administration of chemotherapy. It provides data collection tools for the purpose of quality improvement. It gives an example of oncology nurse job descriptions. It lists the educational classes that are required for oncology nurses. It outlines the professional responsibilities of oncology nurses in the administration of chemotherapy. Answer: ASCO and ONS have collaborated to outline safety standards for the administration of chemotherapy which addresses staffing issues, chemotherapy planning preparation, and administration. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 100. What personal protective equipment is recommended during the cleanup of a hazardous medication spill? Face shield Reusable cloth gown Surgical mask Polyvinyl chloride gloves Face shield Answer: A face shield will provide splash protection to eyes and face when cleaning up a spill and whenever hazardous medications are released into the environment from a spill. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 106. A patient is evaluated to participate in a phase 2 clinical trial. Which of the following is the most important consideration for patient selection? The patient has an adequate performance status. The patient must have metastatic disease. The patient has exhausted all approved treatments. The patient must have had no prior exposure to chemotherapy. The patient has an adequate performance status. Answer: Since a response rate is the primary endpoint of a phase 2 clinical trial, patients entered into these studies must have a specific diagnosis, a good performance status, and minimal prior exposure to chemotherapy (at most 1 or 2 prior regimens). Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 230. A patient with stage IIIC ovarian cancer who has relapsed after receiving first line therapy demonstrates an understanding of her condition by stating: "What clinical trials are available for recurrent disease?" "These symptoms must be a result of chemotherapy." "I know I must have been overdoing it a bit." "I am glad I will not need any additional treatment." "What clinical trials are available for recurrent disease?" Answer: Many patients with stage IIIC ovarian cancer will develop a relapse after successful completion of first line therapies. Clinical trials are appropriate for patients who have had recent recurrences of ovarian cancer and should be explored. Reference: Yarbro, C.H., Wujcik, D., & Gobel, B.H. (Eds.). (2018). Cancer nursing: Principles and practice (8th ed.). Burlington, MA: Jones and Bartlett, p. 1809. The nurse must administer an oral medication which she is concerned may be hazardous. Which reference would assist her in determining the medication's characteristics and safe handling precautions? NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings ONS Statement on the Scope and Standards of Oncology Nursing Practice The Joint Commission Hospital Patient Safety Goals National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings Answer: The National Institute for Occupational Safety and Health maintains a current list of all antineoplastic hazardous medications, their characteristics, and personal protective equipment required for safe handling and administration. Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology Nursing Society, p. 103. A patient with bone metastasis is experiencing uncontrolled pain. The nurse is reviewing the plan of care with the patient and the palliative care team. This is an example of: collaboration. mentoring. professional development. peer review. collaboration. Answer: Effective management of pain requires oncology nurses and other members of the healthcare team to work together with patients and family. Reference: Brant, J.M., & Wickham, R.S. (Eds.). (2013). Statement on the scope and standards of oncology nursing practice: Generalist and advanced practice. Pittsburgh, PA: Oncology Nursing Society, p. 57.

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ONCC Oncology Nursing Knowledge
Certification Test 2026/2027 | Updated Practice
Questions & Correct Answers


Which of the following cancers is associated with the development of disseminated intravascular
coagulation?

Mucin-secreting adenocarcinoma of the breast
Nonhyperdiploid variant multiple myeloma
Primary peritoneal carcinoma
Acral lentiginous melanoma
Mucin-secreting adenocarcinoma of the breast

Answer: The incidence of disseminated intravascular coagulation is associated mostly with
mucin-secreting adenocarcinomas of the prostate, lung, and breast.

Reference: Kaplan, M. (Ed.). (2013). Understanding and managing oncologic emergencies: A
resource for nurses (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 69.


Which of the following is released into the bloodstream in the event of tumor lysis syndrome?

Uric acid
Sodium
Magnesium
Calcium
Uric acid

Answer: Tumor lysis syndrome is a massive, sudden release of cellular contents in to the
bloodstream resulting in elevated uric acid levels.

Reference: Kaplan, M. (Ed.). (2013). Understanding and managing oncologic emergencies: A
resource for nurses (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 440.


Which of the following classes of medication will most significantly increase the risk for the
development of a cytokine-release syndrome reaction?

Monoclonal antibodies
Taxanes
Platinum compounds
Anthracyclines
Monoclonal antibodies

Answer: Monoclonal antibodies can cause cytokine-release syndrome.

Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A
comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 243.

, When a suspected extravasation occurs during the administration of a vesicant, the nurse must
first:

stop the administration of medication and fluids.
remove the peripheral IV or central venous access device.
aspirate the remaining vesicant from the IV tubing.
notify the healthcare provider.
stop the administration of medication and fluids.

Answer: The first step the nurse should take when an extravasation occurs is stopping the
infusion.

Reference: Newton, S., Hickey, M., & Marrs, J. (2017). Mosby's oncology nursing advisor: A
comprehensive guide to clinical practice (2nd ed.). St. Louis, MO: Elsevier Mosby, p. 217.


Which of the following interventions should the nurse perform for a patient who is at risk for
increased intracranial pressure?

Assessing the patient's gag reflex
Limiting suctioning to less than 30 seconds
Keeping the patient's bed in the high Fowler's position
Positioning pillows to hyperextend the neck
Assessing the patient's gag reflex

Answer: Increased intracranial pressure can impair the gag reflex thus affecting the patient's
ability to eat and drink independently.

Reference: Kaplan, M. (Ed.). (2013). Understanding and managing oncologic emergencies: A
resource for nurses (2nd ed.). Pittsburgh, PA: Oncology Nursing Society, p. 185(t).


A dexrazoxane infusion shows efficacy for treating the extravasation of:

an anthracycline.
a nitrosourea.
an alkylating agent.
a plant alkaloid.
an anthracycline.

Answer: Dexrazoxane is the treatment for anthracycline extravasation.

Reference: Polovich, M., Olsen, M., & LeFebvre, K. (Eds.). (2014). Chemotherapy and
biotherapy guidelines and recommendations for practice (4th ed.). Pittsburgh, PA: Oncology
Nursing Society, p. 159(t).


A patient with sepsis reports hematuria and dyspnea. The laboratory values include platelets
37,000/mm3, prothrombin time 21 seconds, partial thromboplastin time 43 seconds, and
fibrinogen 100 mg/dL. Which of the following is the most likely cause?

Disseminated intravascular coagulation
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