MN553 Quiz 2 questions with answers

MN553 Quiz 2 questions with answers
|\ |\ |\ |\ |\




Pharmacokinetics - CORRECT ANSWERS ✔✔The study of:|\ |\ |\ |\ |\ |\




Absorption |\




Distribution |\




Metabolism |\




Excretion


Absorption is impacted by - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\



✔✔Parenteral administration |\




Oral administration
|\ |\




Site of administration
|\ |\ |\




Bioavailability |\

,Peak blood levels
|\ |\




Distribution - CORRECT ANSWERS ✔✔Movement of |\ |\ |\ |\ |\ |\



absorbed drug in bodily fluids throughout body to target
|\ |\ |\ |\ |\ |\ |\ |\ |\



tissues


Patterns of distribution - CORRECT ANSWERS ✔✔Only in
|\ |\ |\ |\ |\ |\ |\ |\



plasma |\




To all body fluids/homogenously
|\ |\ |\




Specific tissues |\ |\




Non-homogenous |\




-Majority


Increased diffusion equals - CORRECT ANSWERS|\ |\ |\ |\ |\ |\



✔✔Increased distribution |\




How much affinity of the drugs to the tissues is impacted
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\



by - CORRECT ANSWERS ✔✔Distribution
|\ |\ |\ |\




What else impacts distribution - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\



✔✔Blood flow |\ |\

, -High flow |\ |\




-Low flow
|\




True or false
|\ |\ |\




Concentration of drugs increased faster in well perfused
|\ |\ |\ |\ |\ |\ |\ |\



organs - CORRECT ANSWERS ✔✔True
|\ |\ |\ |\




Organs with high blood flow - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\



✔✔Kidney |\




Heart
Liver |\




Brain


Organs with low blood flow - CORRECT ANSWERS ✔✔Skin
|\ |\ |\ |\ |\ |\ |\ |\ |\




Skeletal/bone


Characteristics of the blood-brain barrier - CORRECT |\ |\ |\ |\ |\ |\ |\



ANSWERS ✔✔Relatively impenetrable |\ |\ |\




Usually protective |\ |\




Only lipid soluble drugs can cross
|\ |\ |\ |\ |\