Hydromorphone → Therapeutic Class - Answers Opioid analgesic
Hydromorphone → Pharmacologic Class - Answers Opioid agonist
Hydromorphone → Onset, Peak, Duration - Answers Onset: 10-15 min (IV), 30 min (PO); Peak: 30
-90 min; Duration: 3-4 hr
Hydromorphone → Mechanism of Action - Answers Binds to mu-opioid receptors in CNS,
altering perception and response to pain; produces generalized CNS depression.
Hydromorphone → Uses/Indications - Answers Moderate to severe pain (acute and chronic),
analgesia during anesthesia.
Hydromorphone → Side Effects - Answers Sedation, dizziness, nausea, vomiting, constipation,
pruritus.
Hydromorphone → Adverse Effects - Answers Respiratory depression, hypotension, bradycardia,
confusion, seizures.
Hydromorphone → Contraindications - Answers Severe respiratory depression, acute asthma,
paralytic ileus, hypersensitivity.
Hydromorphone → Client/Family Education - Answers Avoid alcohol and CNS depressants; may
cause drowsiness/dizziness; change positions slowly; take with food to reduce GI upset; risk of
dependence.
Hydromorphone → Priority Assessments - Answers Assess pain, level of consciousness,
respiratory rate/depth, blood pressure, and risk for opioid misuse.
Hydromorphone → Implementation Priorities - Answers Administer with caution; dilute IV doses;
monitor closely during titration; have naloxone available for overdose.
Hydromorphone → Monitoring Priorities - Answers Monitor respiratory status, BP, HR, bowel
function, and pain relief. Watch for signs of tolerance, dependence, or abuse.
Oxycodone → Therapeutic Class - Answers Opioid analgesic
Oxycodone → Pharmacologic Class - Answers Opioid agonist
Oxycodone → Onset, Peak, Duration - Answers Onset: 10-15 min (PO); Peak: 60-90 min; Duration:
3-6 hr (immediate release), 12 hr (extended release)
Oxycodone → Mechanism of Action - Answers Binds to opioid receptors in the CNS, altering
perception and response to pain while producing CNS depression.
Oxycodone → Uses/Indications - Answers Moderate to severe pain requiring long-term opioid
,treatment when alternatives are inadequate.
Oxycodone → Side Effects - Answers Constipation, nausea, vomiting, sedation, dizziness,
pruritus.
Oxycodone → Adverse Effects - Answers Respiratory depression, hypotension, tolerance,
dependence, abuse.
Oxycodone → Contraindications - Answers Severe respiratory depression, paralytic ileus,
acute/severe asthma.
Oxycodone → Client/Family Education - Answers Swallow ER tablets whole; avoid alcohol/CNS
depressants; may cause drowsiness/dizziness; encourage fluids and fiber to prevent
constipation.
Oxycodone → Priority Assessments - Answers Assess pain, RR, BP, level of consciousness, and
bowel function.
Oxycodone → Implementation Priorities - Answers Give with food to minimize GI upset; ER
formulations must not be crushed/chewed; naloxone should be available.
Oxycodone → Monitoring Priorities - Answers Monitor respiratory status, sedation level, and
pain relief; assess for misuse/abuse.
Tramadol → Therapeutic Class - Answers Centrally acting analgesic
Tramadol → Pharmacologic Class - Answers Opioid agonist + serotonin/norepinephrine
reuptake inhibitor (SNRI-like)
Tramadol → Onset, Peak, Duration - Answers Onset: 1 hr (PO); Peak: 2-3 hr; Duration: 4-6 hr
Tramadol → Mechanism of Action - Answers Binds to mu-opioid receptors and inhibits reuptake
of serotonin/norepinephrine, altering pain perception.
Tramadol → Uses/Indications - Answers Moderate to moderately severe pain.
Tramadol → Side Effects - Answers Dizziness, nausea, constipation, headache, somnolence.
Tramadol → Adverse Effects - Answers Seizures, serotonin syndrome, respiratory depression,
dependence.
Tramadol → Contraindications - Answers Severe asthma, respiratory depression, history of
seizures, concurrent MAOI use.
Tramadol → Client/Family Education - Answers May cause dizziness/drowsiness; avoid
alcohol/CNS depressants; report seizures or mood changes; risk for serotonin syndrome if
taken with SSRIs/SNRIs.
, Tramadol → Priority Assessments - Answers Assess pain, neuro status, seizure risk, and history
of serotonin syndrome.
Tramadol → Implementation Priorities - Answers Use lowest effective dose; avoid abrupt
discontinuation; naloxone may not fully reverse toxicity.
Tramadol → Monitoring Priorities - Answers Monitor for serotonin syndrome (agitation,
hallucinations, tachycardia, hyperreflexia); monitor for seizure activity and respiratory
depression.
Naloxone → Therapeutic Class - Answers Opioid antidote
Naloxone → Pharmacologic Class - Answers Opioid antagonist
Naloxone → Onset, Peak, Duration - Answers Onset: 2 min (IV), 3-5 min (IM/SQ); Peak: 5-15 min;
Duration: 30-120 min
Naloxone → Mechanism of Action - Answers Competitively blocks opioid receptors, reversing
effects of opioids including respiratory/CNS depression.
Naloxone → Uses/Indications - Answers Opioid overdose, reversal of postoperative opioid
depression.
Naloxone → Side Effects - Answers Nausea, vomiting, sweating, tremors.
Naloxone → Adverse Effects - Answers Ventricular arrhythmias, severe hypertension, pulmonary
edema.
Naloxone → Contraindications - Answers Hypersensitivity; use with caution in cardiac disease
and opioid dependence (may precipitate withdrawal).
Naloxone → Client/Family Education - Answers Explain purpose and effects; may cause acute
withdrawal symptoms; teach family how to administer nasal spray in emergencies.
Naloxone → Priority Assessments - Answers Monitor respiratory status, LOC, and opioid use
history.
Naloxone → Implementation Priorities - Answers Administer IV, IM, SQ, or intranasal; repeat
doses may be needed due to short duration.
Naloxone → Monitoring Priorities - Answers Monitor RR, HR, BP, and oxygen saturation;
reassess frequently since naloxone wears off before opioids.
Buprenorphine → Therapeutic Class - Answers Opioid analgesic
Buprenorphine → Pharmacologic Class - Answers Opioid agonist-antagonist
Buprenorphine → Onset, Peak, Duration - Answers Onset: 15 min (IM), 30-60 min (SL); Peak: 1-4