ABIM Set 2 Questions with Correct Answers Latest Update 2025/2026
organism most commonly assoc with HUS - Answers shiga-like O157 Ecoli
features of HUS - Answers hemolytic anemia, thrombocytopenia, and acute kidney injury
most common cause of jaundice in pregnancy - Answers viral hepatitis
PPI regiments after EGD with hemostasis of ulcer - Answers bolus 80 then drip or bolus 80 and
high dose PPI 2-4 times a day
meds safe in pregnancy for crohns - Answers sulfasalazine, budesonide, azathioprine, and
ustekinumab
how to ID food specific triggers in EOE - Answers empiric food elimination trial, no allergen or
skin prick tests
a well-demarcated multicystic lesion in the head of the pancreas with central calcification -
Answers microcystic serous cystadenoma
surveillance for microcystic serous cystadenoma - Answers none and reassurance, no testing,
ID based on image alone
lesion with honeycomb appearance and central calcifications - Answers microcystic serous
cystadenoma
abdominal aortic mycotic aneurysms are assoc with what organisms - Answers staph and
salmonella
In a sitz marker test, normal is what percent of markers past in 5 days? - Answers 80% in 5 days
B12 def will develop after illeal resection after how much time? - Answers several years
in ileal resection, you will immediately get what def - Answers decreased overall bile, that means
decreased fat resorportion and low ADEK
most common adverse effect of dilation in EOE - Answers post procedural pain
hamartomas and ganglioneuromas in the gastrointestinal tract are assoc with what condition -
Answers cowden syndrome
Cowden syndrome is assoc with what gene - Answers PTEN
cancers associated with Cowden syndrome - Answers breast cancer, thyroid cancer,
endometrial cancer, renal cell cancer, colorectal cancer and melanoma
what condition is assoc with glycogenic acanthosis of the esophagus (as in the endoscopy
picture above), as well as macrocephaly and skin lesions called trichilemmomas - Answers
,cowden syndromee
First line therapy for achalasia - Answers POEM, laparoscopic Heller myotomy, or pneumatic
dilation to 30 mm or greater
medication for short gut - Answers Tedglutide, don't use cholestyramine, because that will lead
to bound bile acid and they have low bile, because they dpn't have bowel to reabsorb bile
bisphosphonates can cause - Answers pill esophagitis
ppi in bleed prior to EGD did what - Answers reduced risk of need for endoscopic therapies
what to do with a lesion in colon with central depression and amorphous surface pattern with
areas of disrupted vessel - Answers biopsy center- sign of cancer and then surgery
screening nterval for Patients with 1 to 2 small (<10 mm) adenomatous polyps - Answers every
7 to 10 years
what organisms are are risk factors for cholangiocarcinoma - Answers Opisthorchis viverrini
and Clonorchis sinensis
GB cancer is most common in - Answers a female preponderance, and they are more common
in individuals of Mexican, Chilean, Bolivian, Native American, and Japanese descent
feature that is a risk factor for GB cancer - Answers GB calcification of the wall gallstones,
gallbladder polyps (particularly >1 cm), primary sclerosing cholangitis
subacute or chronic Wilson treatment - Answers Trientine and D-penicillamine
Labs expected in ACUTE wilson - Answers elevated AST/ALT and then low normal ALK
combs negatve hemolysis associated with what liver condition - Answers Wilsons- copper-
induced lysis of red blood cells
What to do in HBV and HCV co infection - Answers Patients coinfected with positive surface
antigen and evidence of active replication should receive HBV therapy during treatment for HCV
and at least 12 weeks after therapy with close monitoring.
Increased signaling of what causes Mentiers - Answers EGFR
symptoms of Mentiers - Answers enlarged gastric folds excessive mucous production,
hypoproteinemia, and reduced acid production (achlorhydria)
Gastric mucosal biopsies reveal prominent expansion of the gastric pits with a corkscrew, as
well as cystic dilation of glands in the basal portion of the mucosa is ssoc with what condition -
Answers Mentiers
the cholera toxin that ultimately results in intraluminal electrolyte transport and diarrhea. -
, Answers ganglioside GM1
people at higher risk for yersenia infection - Answers iron overloaded, like sickle cell,
thalassemia, hemochromatosis, (Salmonella also likes iron)
risk factors for dysplasia in fundic gland polyps - Answers increasing size of the largest fundic
gland polyps, the presence of antral gastritis and in patients with familial adenomatous
polyposis (FAP) syndrome
caloric goal in cirrhosis - Answers total caloric (30-35 kg/kg daily)
protein goal in cirrhosis - Answers protein (1.2-1.5 g/kg daily)
importance of diet in cirrhosis - Answers avoid periods of fasting, late evening snack
which vaccines are live: DTaP, Hep B, rotavirus, pneumococcal - Answers rotavirus
who needs to avoid live viruses - Answers babies born to woman who were on TNF for first 6
months of life
osmotic gap and pH in lactose intolerance - Answers osmotic gap >100, normall >125, pH<5.3
prednisolone reduces - Answers 28 day mortality
Type 1 Hereditary hemochromatosis - Answers hereditary- HFE gene mutation
Type 2 Hemochromatosis - Answers juvenille causes low hepcidin levels and then no negative
feedback to enterocytes
Type 3 hemochromatosis - Answers TFR related causes low hepcidin levels and loss of negative
feedback
Type 4 hemochromatosis - Answers ferroportin, autosomal dominant effects predominantly
African patients, the ferroportin does not respond to the negative feedback effect of hepcidin.
Assoca with SLC40A gene
what to do in azathioprine panreatitis - Answers stop, do not restart, don't need tpmt levels
factors that increase risk of crohns post op recurrence - Answers Tobacco, younger age at
diagnosis (<30 year of age), and prior CD surgery are high-risk factors for postoperative CD
recurrence
when to start HCV treatment after transplant with HCV positive organ - Answers within the first
month
features of protein losing enteropathy - Answers small intestine with white specks, elevated
protein in the stool and fat soluble vitamin def
organism most commonly assoc with HUS - Answers shiga-like O157 Ecoli
features of HUS - Answers hemolytic anemia, thrombocytopenia, and acute kidney injury
most common cause of jaundice in pregnancy - Answers viral hepatitis
PPI regiments after EGD with hemostasis of ulcer - Answers bolus 80 then drip or bolus 80 and
high dose PPI 2-4 times a day
meds safe in pregnancy for crohns - Answers sulfasalazine, budesonide, azathioprine, and
ustekinumab
how to ID food specific triggers in EOE - Answers empiric food elimination trial, no allergen or
skin prick tests
a well-demarcated multicystic lesion in the head of the pancreas with central calcification -
Answers microcystic serous cystadenoma
surveillance for microcystic serous cystadenoma - Answers none and reassurance, no testing,
ID based on image alone
lesion with honeycomb appearance and central calcifications - Answers microcystic serous
cystadenoma
abdominal aortic mycotic aneurysms are assoc with what organisms - Answers staph and
salmonella
In a sitz marker test, normal is what percent of markers past in 5 days? - Answers 80% in 5 days
B12 def will develop after illeal resection after how much time? - Answers several years
in ileal resection, you will immediately get what def - Answers decreased overall bile, that means
decreased fat resorportion and low ADEK
most common adverse effect of dilation in EOE - Answers post procedural pain
hamartomas and ganglioneuromas in the gastrointestinal tract are assoc with what condition -
Answers cowden syndrome
Cowden syndrome is assoc with what gene - Answers PTEN
cancers associated with Cowden syndrome - Answers breast cancer, thyroid cancer,
endometrial cancer, renal cell cancer, colorectal cancer and melanoma
what condition is assoc with glycogenic acanthosis of the esophagus (as in the endoscopy
picture above), as well as macrocephaly and skin lesions called trichilemmomas - Answers
,cowden syndromee
First line therapy for achalasia - Answers POEM, laparoscopic Heller myotomy, or pneumatic
dilation to 30 mm or greater
medication for short gut - Answers Tedglutide, don't use cholestyramine, because that will lead
to bound bile acid and they have low bile, because they dpn't have bowel to reabsorb bile
bisphosphonates can cause - Answers pill esophagitis
ppi in bleed prior to EGD did what - Answers reduced risk of need for endoscopic therapies
what to do with a lesion in colon with central depression and amorphous surface pattern with
areas of disrupted vessel - Answers biopsy center- sign of cancer and then surgery
screening nterval for Patients with 1 to 2 small (<10 mm) adenomatous polyps - Answers every
7 to 10 years
what organisms are are risk factors for cholangiocarcinoma - Answers Opisthorchis viverrini
and Clonorchis sinensis
GB cancer is most common in - Answers a female preponderance, and they are more common
in individuals of Mexican, Chilean, Bolivian, Native American, and Japanese descent
feature that is a risk factor for GB cancer - Answers GB calcification of the wall gallstones,
gallbladder polyps (particularly >1 cm), primary sclerosing cholangitis
subacute or chronic Wilson treatment - Answers Trientine and D-penicillamine
Labs expected in ACUTE wilson - Answers elevated AST/ALT and then low normal ALK
combs negatve hemolysis associated with what liver condition - Answers Wilsons- copper-
induced lysis of red blood cells
What to do in HBV and HCV co infection - Answers Patients coinfected with positive surface
antigen and evidence of active replication should receive HBV therapy during treatment for HCV
and at least 12 weeks after therapy with close monitoring.
Increased signaling of what causes Mentiers - Answers EGFR
symptoms of Mentiers - Answers enlarged gastric folds excessive mucous production,
hypoproteinemia, and reduced acid production (achlorhydria)
Gastric mucosal biopsies reveal prominent expansion of the gastric pits with a corkscrew, as
well as cystic dilation of glands in the basal portion of the mucosa is ssoc with what condition -
Answers Mentiers
the cholera toxin that ultimately results in intraluminal electrolyte transport and diarrhea. -
, Answers ganglioside GM1
people at higher risk for yersenia infection - Answers iron overloaded, like sickle cell,
thalassemia, hemochromatosis, (Salmonella also likes iron)
risk factors for dysplasia in fundic gland polyps - Answers increasing size of the largest fundic
gland polyps, the presence of antral gastritis and in patients with familial adenomatous
polyposis (FAP) syndrome
caloric goal in cirrhosis - Answers total caloric (30-35 kg/kg daily)
protein goal in cirrhosis - Answers protein (1.2-1.5 g/kg daily)
importance of diet in cirrhosis - Answers avoid periods of fasting, late evening snack
which vaccines are live: DTaP, Hep B, rotavirus, pneumococcal - Answers rotavirus
who needs to avoid live viruses - Answers babies born to woman who were on TNF for first 6
months of life
osmotic gap and pH in lactose intolerance - Answers osmotic gap >100, normall >125, pH<5.3
prednisolone reduces - Answers 28 day mortality
Type 1 Hereditary hemochromatosis - Answers hereditary- HFE gene mutation
Type 2 Hemochromatosis - Answers juvenille causes low hepcidin levels and then no negative
feedback to enterocytes
Type 3 hemochromatosis - Answers TFR related causes low hepcidin levels and loss of negative
feedback
Type 4 hemochromatosis - Answers ferroportin, autosomal dominant effects predominantly
African patients, the ferroportin does not respond to the negative feedback effect of hepcidin.
Assoca with SLC40A gene
what to do in azathioprine panreatitis - Answers stop, do not restart, don't need tpmt levels
factors that increase risk of crohns post op recurrence - Answers Tobacco, younger age at
diagnosis (<30 year of age), and prior CD surgery are high-risk factors for postoperative CD
recurrence
when to start HCV treatment after transplant with HCV positive organ - Answers within the first
month
features of protein losing enteropathy - Answers small intestine with white specks, elevated
protein in the stool and fat soluble vitamin def
