MCB 100: E4 L34 QUESTIONS WITH COMPLETE
SOLUTIONS
Alexander Fleming Correct Answers -Penicillin released from
Penicillium
Antimicrobial Agents (Antimicrobials) Correct Answers -drugs
that treat infections
Chemotherapeutic Agents Correct Answers -drugs that act
against diseases
Disruption of Cytoplasmic Membranes Correct Answers -
Amphotericin B binds ergosterol and creates a pore in the
membrane
-selectivity is based on specific differences in chemical makeup
of cytoplasmic membranes (why it forms pores in pathogen
membranes and not ours)
-Amphotericin B specifically targets fungal infections and
leishmaniasis
Drugs Correct Answers -chemicals that affect physiology in any
manner
ICLICKER: Correct Answers
Inhibition of Cell Wall Synthesis Correct Answers -bacteria
have weakened cell walls and eventually lyse
-prevent cross-linkage of NAM subunits
-Beta-lactams, EX: penicillin
, Inhibition of DNA Replication/RNA Synthesis Correct Answers
-nucleotide or nucleoside analogs
-interfere with function of nucleic acids
-distort shapes of nucleic acid molecules
-often used against viruses
-effective against rapidly dividing cancer cells
Inhibition of Metabolic Pathways Correct Answers -
Antimetabolic agents can be effective when pathogen and host
metabolic processes differ
-structural analogs bind to the enzyme and DNA/RNA cannot be
produced
Inhibition of Protein Synthesis Correct Answers -interference
with prokaryotic ribosomes (70S; 30S and 50S)
-change 30S shape, so mRNA is read wrong; incorrect amino
acids added
-block docking site of tRNA
-block peptide bond formation; bonds cannot form
-bind 50S subunit, blocking proper mRNA movement; synthesis
stops
-antisense nucleic acid is added; blocks formation of ribosomal
subunits
-inhibition of translation initiation
Most antibiotics come from what source?
A. Fungi
B. Bacteria
C. Plants
SOLUTIONS
Alexander Fleming Correct Answers -Penicillin released from
Penicillium
Antimicrobial Agents (Antimicrobials) Correct Answers -drugs
that treat infections
Chemotherapeutic Agents Correct Answers -drugs that act
against diseases
Disruption of Cytoplasmic Membranes Correct Answers -
Amphotericin B binds ergosterol and creates a pore in the
membrane
-selectivity is based on specific differences in chemical makeup
of cytoplasmic membranes (why it forms pores in pathogen
membranes and not ours)
-Amphotericin B specifically targets fungal infections and
leishmaniasis
Drugs Correct Answers -chemicals that affect physiology in any
manner
ICLICKER: Correct Answers
Inhibition of Cell Wall Synthesis Correct Answers -bacteria
have weakened cell walls and eventually lyse
-prevent cross-linkage of NAM subunits
-Beta-lactams, EX: penicillin
, Inhibition of DNA Replication/RNA Synthesis Correct Answers
-nucleotide or nucleoside analogs
-interfere with function of nucleic acids
-distort shapes of nucleic acid molecules
-often used against viruses
-effective against rapidly dividing cancer cells
Inhibition of Metabolic Pathways Correct Answers -
Antimetabolic agents can be effective when pathogen and host
metabolic processes differ
-structural analogs bind to the enzyme and DNA/RNA cannot be
produced
Inhibition of Protein Synthesis Correct Answers -interference
with prokaryotic ribosomes (70S; 30S and 50S)
-change 30S shape, so mRNA is read wrong; incorrect amino
acids added
-block docking site of tRNA
-block peptide bond formation; bonds cannot form
-bind 50S subunit, blocking proper mRNA movement; synthesis
stops
-antisense nucleic acid is added; blocks formation of ribosomal
subunits
-inhibition of translation initiation
Most antibiotics come from what source?
A. Fungi
B. Bacteria
C. Plants
