PHA 317 COMPREHENSIVE REVIEW FOR FINAL QUESTIONS AND
ANSWERS
Cup and Bob type of viscometer may be used for gels and pastes - CORRECT ANSWER✅✅True
For nitroglycerine (NTG), it is important to counsel patient not to remove tablets from packaging until
they actually use the tablets. This is due to what characteristic of NTG? - CORRECT ANSWER✅✅NTG is
susceptible to loss by sublimation at room temperature
The most stable polymorph is always used for better clinical outcomes - CORRECT ANSWER✅✅False
Which of the following does NOT increase aqueous solubility - CORRECT ANSWER✅✅Increasing the
length of a straight chain organic compounds
Increasing which of the following will increase permeability of a molecule across a biological membrane
- CORRECT ANSWER✅✅Diffusivity of the molecule
100mL of water was added to a 200mL solution. When the total volume was measured, it was found
only 298mL even if there is no loss of material during mixing. Is this a real solution - CORRECT
ANSWER✅✅Yes
1g of a drug s soluble in 10.50 L of water. Which one of the following correctly define its solubility as per
USP definition - CORRECT ANSWER✅✅Practically insoluble
A matter that exhibits plastic flow, below its yield value would behave as - CORRECT ANSWER✅✅Elastic
flow
The arrhenius equation of rheology expresses the relationship between - CORRECT
ANSWER✅✅Viscosity and temperature
Ostwald viscometer is used for - CORRECT ANSWER✅✅liquids that flow relatively easily
,Pseudoplatic flow has a yield value - CORRECT ANSWER✅✅False
The key factor in the viscoelasticity of blood are - CORRECT ANSWER✅✅both aggregation and
deformability
1 centipoise is equal to - CORRECT ANSWER✅✅0.01 poise
If the shearing stress is directly proportional to the rate of shear the liquid exhibits a - CORRECT
ANSWER✅✅Newtonian flow
Which one of the following facts are correct with respect to thixotropy - CORRECT
ANSWER✅✅Exhibited by shear thinning systems, such as pseudoplastic and plastic liquids
Can be defined as an isothermal and comparatively slow recovery, on standing of a material, of a
consistency lost through shearing
Behavior is useful for many pharmaceutical preps (suspensions)
Which one of the following is the most desirable flow characteristic for a dosage form design - CORRECT
ANSWER✅✅Thixotropic flow
Under which situation will the viscosity of oil increase - CORRECT ANSWER✅✅As temperature
decreases
Viscosity of an unknown liquid is 0.580 cp at 25 degrees celsius and the density is 0.858/cm cubed. What
is the kinematic viscosity of the unknown liquid - CORRECT ANSWER✅✅0.676 centistrokes
Plastic flow is associated with - CORRECT ANSWER✅✅Suspensions
For Newtonian fluids, if the rate of shear is increased two times from its original value while the viscosity
remains constant. What change could you expect in shearing stress of that liquid - CORRECT
ANSWER✅✅Double it's original value
,Thixotropy is a special characteristic that is exhibited by shear thinning systems, such as - CORRECT
ANSWER✅✅Plastic and Pseudoplastic
Polymers in a solution generally exhibit plastic flow - CORRECT ANSWER✅✅False
A solution isoosmotic with blood would be isotonic too - CORRECT ANSWER✅✅False
Molarity of a solution does not depend on temperature of the solution - CORRECT ANSWER✅✅False
What is the normality of the 100mL solution containing 585 mg of NaCl in water - CORRECT
ANSWER✅✅0.1N
Indicate which of the following is correct about osmosis - CORRECT ANSWER✅✅Osmotic pressure is
proportional to number of ions or molecules of solute dissolved in solvent
Which one of the following statements is correct about diarrhea - CORRECT ANSWER✅✅There is a co-
transport system unaffected by diarrhea causing microorganism, which transports Na+ ions to blood
only when glucose is also present
Hydrogen peroxide is stored in dark container to prevent it from - CORRECT ANSWER✅✅photolysis
The rate of specific acid and base catalysis is affected by concentration of undissociated buffer
components in addition to hydronium and hydroxyl ion concentration - CORRECT ANSWER✅✅false
the release of a drug from matrix system occurs by - CORRECT ANSWER✅✅diffusion from the matrix
system and erosion of the matrix system
dissolution rate can be increased by - CORRECT ANSWER✅✅increasing the diffusion coefficient
ampicillin degrades much faster in water than in alcohol because - CORRECT ANSWER✅✅water, being a
high dielectric constant solvent, converts the neutral ampicillin into a charged transition complex
, Which is not a variable in the Noyes and Whitney equation - CORRECT ANSWER✅✅pH
Hixson-Crowell Cube Root Law is capable of determining dissolution rate when - CORRECT
ANSWER✅✅the shape of the dissolving particle is uniform and does not change during dissolution
Dissolution testing is conducted by manufacturers under what condition - CORRECT ANSWER✅✅Sink
Which of the following equations predicts the stability of a drug at room temp from experiments at
accelerated condition at high temp - CORRECT ANSWER✅✅The Arrhenius Equation
Initial burst release is observed for which of the following matrix-based controlled drug release system -
CORRECT ANSWER✅✅Hydrophilic or swellable matrix systems
An increase in temp by 10 deg. Celcius near room temperature is known to cause - CORRECT
ANSWER✅✅a 2-4 fold increase in reaction rate for many reactions
Insoluble polymers such as ethyl cellulose, methylmethacrylate, or polyvinvyl acetate are used for
making inert matrix-based extended drug release systems - CORRECT ANSWER✅✅true
the rate of general acid and base catalysis is affected by concentration of undissociated buffer
components in addition to hydronium and hydroxyl ion concentration - CORRECT ANSWER✅✅True
Following are some approaches to prevent the oxidative degradation of drug - CORRECT
ANSWER✅✅using an initiation inhibitor such as EDTA, using colored glass containers, using chain
breakers such as alpha tocopherol, using oxygen scavengers such as sodium metabisulfite and ascorbic
acid
The initial concentration of active principle in an aqueous preparation was 5.0 * 10^-3 g/ml. After 10
months the concentration was found to be 4.2 * 10^-3 g/ml. The drug is known to be ineffective after it
has decomposed to 70% of its original concentration. Assuming that decomposition follows first order
kinetics, calculate the expiry date of the drug preparation. - CORRECT ANSWER✅✅20.5 months
ANSWERS
Cup and Bob type of viscometer may be used for gels and pastes - CORRECT ANSWER✅✅True
For nitroglycerine (NTG), it is important to counsel patient not to remove tablets from packaging until
they actually use the tablets. This is due to what characteristic of NTG? - CORRECT ANSWER✅✅NTG is
susceptible to loss by sublimation at room temperature
The most stable polymorph is always used for better clinical outcomes - CORRECT ANSWER✅✅False
Which of the following does NOT increase aqueous solubility - CORRECT ANSWER✅✅Increasing the
length of a straight chain organic compounds
Increasing which of the following will increase permeability of a molecule across a biological membrane
- CORRECT ANSWER✅✅Diffusivity of the molecule
100mL of water was added to a 200mL solution. When the total volume was measured, it was found
only 298mL even if there is no loss of material during mixing. Is this a real solution - CORRECT
ANSWER✅✅Yes
1g of a drug s soluble in 10.50 L of water. Which one of the following correctly define its solubility as per
USP definition - CORRECT ANSWER✅✅Practically insoluble
A matter that exhibits plastic flow, below its yield value would behave as - CORRECT ANSWER✅✅Elastic
flow
The arrhenius equation of rheology expresses the relationship between - CORRECT
ANSWER✅✅Viscosity and temperature
Ostwald viscometer is used for - CORRECT ANSWER✅✅liquids that flow relatively easily
,Pseudoplatic flow has a yield value - CORRECT ANSWER✅✅False
The key factor in the viscoelasticity of blood are - CORRECT ANSWER✅✅both aggregation and
deformability
1 centipoise is equal to - CORRECT ANSWER✅✅0.01 poise
If the shearing stress is directly proportional to the rate of shear the liquid exhibits a - CORRECT
ANSWER✅✅Newtonian flow
Which one of the following facts are correct with respect to thixotropy - CORRECT
ANSWER✅✅Exhibited by shear thinning systems, such as pseudoplastic and plastic liquids
Can be defined as an isothermal and comparatively slow recovery, on standing of a material, of a
consistency lost through shearing
Behavior is useful for many pharmaceutical preps (suspensions)
Which one of the following is the most desirable flow characteristic for a dosage form design - CORRECT
ANSWER✅✅Thixotropic flow
Under which situation will the viscosity of oil increase - CORRECT ANSWER✅✅As temperature
decreases
Viscosity of an unknown liquid is 0.580 cp at 25 degrees celsius and the density is 0.858/cm cubed. What
is the kinematic viscosity of the unknown liquid - CORRECT ANSWER✅✅0.676 centistrokes
Plastic flow is associated with - CORRECT ANSWER✅✅Suspensions
For Newtonian fluids, if the rate of shear is increased two times from its original value while the viscosity
remains constant. What change could you expect in shearing stress of that liquid - CORRECT
ANSWER✅✅Double it's original value
,Thixotropy is a special characteristic that is exhibited by shear thinning systems, such as - CORRECT
ANSWER✅✅Plastic and Pseudoplastic
Polymers in a solution generally exhibit plastic flow - CORRECT ANSWER✅✅False
A solution isoosmotic with blood would be isotonic too - CORRECT ANSWER✅✅False
Molarity of a solution does not depend on temperature of the solution - CORRECT ANSWER✅✅False
What is the normality of the 100mL solution containing 585 mg of NaCl in water - CORRECT
ANSWER✅✅0.1N
Indicate which of the following is correct about osmosis - CORRECT ANSWER✅✅Osmotic pressure is
proportional to number of ions or molecules of solute dissolved in solvent
Which one of the following statements is correct about diarrhea - CORRECT ANSWER✅✅There is a co-
transport system unaffected by diarrhea causing microorganism, which transports Na+ ions to blood
only when glucose is also present
Hydrogen peroxide is stored in dark container to prevent it from - CORRECT ANSWER✅✅photolysis
The rate of specific acid and base catalysis is affected by concentration of undissociated buffer
components in addition to hydronium and hydroxyl ion concentration - CORRECT ANSWER✅✅false
the release of a drug from matrix system occurs by - CORRECT ANSWER✅✅diffusion from the matrix
system and erosion of the matrix system
dissolution rate can be increased by - CORRECT ANSWER✅✅increasing the diffusion coefficient
ampicillin degrades much faster in water than in alcohol because - CORRECT ANSWER✅✅water, being a
high dielectric constant solvent, converts the neutral ampicillin into a charged transition complex
, Which is not a variable in the Noyes and Whitney equation - CORRECT ANSWER✅✅pH
Hixson-Crowell Cube Root Law is capable of determining dissolution rate when - CORRECT
ANSWER✅✅the shape of the dissolving particle is uniform and does not change during dissolution
Dissolution testing is conducted by manufacturers under what condition - CORRECT ANSWER✅✅Sink
Which of the following equations predicts the stability of a drug at room temp from experiments at
accelerated condition at high temp - CORRECT ANSWER✅✅The Arrhenius Equation
Initial burst release is observed for which of the following matrix-based controlled drug release system -
CORRECT ANSWER✅✅Hydrophilic or swellable matrix systems
An increase in temp by 10 deg. Celcius near room temperature is known to cause - CORRECT
ANSWER✅✅a 2-4 fold increase in reaction rate for many reactions
Insoluble polymers such as ethyl cellulose, methylmethacrylate, or polyvinvyl acetate are used for
making inert matrix-based extended drug release systems - CORRECT ANSWER✅✅true
the rate of general acid and base catalysis is affected by concentration of undissociated buffer
components in addition to hydronium and hydroxyl ion concentration - CORRECT ANSWER✅✅True
Following are some approaches to prevent the oxidative degradation of drug - CORRECT
ANSWER✅✅using an initiation inhibitor such as EDTA, using colored glass containers, using chain
breakers such as alpha tocopherol, using oxygen scavengers such as sodium metabisulfite and ascorbic
acid
The initial concentration of active principle in an aqueous preparation was 5.0 * 10^-3 g/ml. After 10
months the concentration was found to be 4.2 * 10^-3 g/ml. The drug is known to be ineffective after it
has decomposed to 70% of its original concentration. Assuming that decomposition follows first order
kinetics, calculate the expiry date of the drug preparation. - CORRECT ANSWER✅✅20.5 months
