Attention deficit hyperactivity disorder (ADHD)
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- involving a persistent pattern of inattention and/or hyperactivity that
interferes with daily function/development for at least 6 months for a child
under the age of 12
,Assessing ASD
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Children are evaluated along two domains:
- social and communication disturbances
- restricted range of interests and performance of repetitive behaviours
and activities
Within each domain, clinicians specify one of three severity levels:
- requiring support
- requiring substantial support
- requiring very little substantial support
Asthma
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- hyperinflammatory state typically involving environmental triggers (as
opposed to infection)
- chronic inflammatory disorder of the airways
- developed by 45% of children hospitalized by RSV
- affected 3 million Canadian, including 600,00 children
- 6/10 people with this do not have control of their disease and are at risk
for severe, life-threatening asthma attack and permanent lung damage
- two types:
1. extrinsic
2. intrinsic
,Moderate dehydration
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- tachycardia
- dry mucous membranes
- irritability
- orthostatic hypotension
- delayed cap refill
- cool extremities
- sunken fontanelle
- decreased urine output
Syncytia
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- budding from an infected cell and immediate fusion with
another cell allows direct cell-cell spread without
immediately altering the immune system
- leads to the formation of multi-nucleate enlarged cells
- allows for the spreading of some viruses (e.g., RSV)
Hyposensitization (desensitization)
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, - immune system has a built in tolerance response to commonly
encountered antigens
- a low dose exposure to allergen can trigger this response
- after 1-2 years treatment, B-cells still activated but fewer IgE, more IgG
- after around 2 years "Treg" cells are observed that recognize the allergen
but actively suppress the immune response
Prevalence of FASD
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- in Canada it is estimated that nine babies in every 1,000 are born with
FASD each year
- variations based on the demographic, social, geographical, and cultural
factors that underlie drinking during pregnancy
Chronic neuroinflammation with microglial activation (mechanism of ASD)
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- damaged neurons and synapses are removed by the macrophages of the
CNS, altering normal brain function
Effects of ASD on cognition
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- involving a persistent pattern of inattention and/or hyperactivity that
interferes with daily function/development for at least 6 months for a child
under the age of 12
,Assessing ASD
Give this one a try later!
Children are evaluated along two domains:
- social and communication disturbances
- restricted range of interests and performance of repetitive behaviours
and activities
Within each domain, clinicians specify one of three severity levels:
- requiring support
- requiring substantial support
- requiring very little substantial support
Asthma
Give this one a try later!
- hyperinflammatory state typically involving environmental triggers (as
opposed to infection)
- chronic inflammatory disorder of the airways
- developed by 45% of children hospitalized by RSV
- affected 3 million Canadian, including 600,00 children
- 6/10 people with this do not have control of their disease and are at risk
for severe, life-threatening asthma attack and permanent lung damage
- two types:
1. extrinsic
2. intrinsic
,Moderate dehydration
Give this one a try later!
- tachycardia
- dry mucous membranes
- irritability
- orthostatic hypotension
- delayed cap refill
- cool extremities
- sunken fontanelle
- decreased urine output
Syncytia
Give this one a try later!
- budding from an infected cell and immediate fusion with
another cell allows direct cell-cell spread without
immediately altering the immune system
- leads to the formation of multi-nucleate enlarged cells
- allows for the spreading of some viruses (e.g., RSV)
Hyposensitization (desensitization)
Give this one a try later!
, - immune system has a built in tolerance response to commonly
encountered antigens
- a low dose exposure to allergen can trigger this response
- after 1-2 years treatment, B-cells still activated but fewer IgE, more IgG
- after around 2 years "Treg" cells are observed that recognize the allergen
but actively suppress the immune response
Prevalence of FASD
Give this one a try later!
- in Canada it is estimated that nine babies in every 1,000 are born with
FASD each year
- variations based on the demographic, social, geographical, and cultural
factors that underlie drinking during pregnancy
Chronic neuroinflammation with microglial activation (mechanism of ASD)
Give this one a try later!
- damaged neurons and synapses are removed by the macrophages of the
CNS, altering normal brain function
Effects of ASD on cognition
Give this one a try later!
