MIDTERM EXAM: NR507 ADVANCED
PATHOPHYSIOLOGY, 2025/2026 (100
QUESTIONS WITH ANSWERS &
RATIONALES)/ WITH CORRECT /ACCURATE
ANSWERS
AT CHAMBERLAIN UNIVERSITY'S COLLEGE
OF NURSING
UPDATED
,⭐ HYPERSENSITIVITY & IMMUNOLOGY
1. What is hypersensitivity type IV?
A. Immediate IgE-mediated
B. Immune complex–mediated
C. Delayed-type hypersensitivity
D. Antibody-mediated cytotoxic
Answer: C
Rationale: Type IV is delayed, T-cell–mediated hypersensitivity.
2. Hypersensitivity type IV is mediated by what?
A. IgE
B. IgG
C. Complement
D. T-cells
Answer: D
Rationale: Type IV mechanisms rely on T-cell activation.
3. Which is an example of hypersensitivity type IV?
A. Anaphylaxis
B. Serum sickness
C. Mantoux TB skin test
D. Graves disease
Answer: C
Rationale: The TB skin test is classic delayed hypersensitivity.
4. Organ rejection is associated with which hypersensitivity?
A. Type I
B. Type II
C. Type IV
D. Both B & C
Answer: D
Rationale: Transplant rejection involves antibody-mediated (II) and T-cell–mediated (IV)
mechanisms.
, 5. Contact dermatitis is which type of reaction?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: D
Rationale: Poison ivy/contact dermatitis is T-cell–mediated.
6. Anaphylaxis is what type of hypersensitivity?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: A
Rationale: IgE-mediated mast cell degranulation causes anaphylaxis.
7. Graves disease is which hypersensitivity type?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: B
Rationale: Antibody-mediated receptor stimulation is Type II.
8. Serum sickness is which type?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: C
Rationale: Immune complex deposition defines Type III.
PATHOPHYSIOLOGY, 2025/2026 (100
QUESTIONS WITH ANSWERS &
RATIONALES)/ WITH CORRECT /ACCURATE
ANSWERS
AT CHAMBERLAIN UNIVERSITY'S COLLEGE
OF NURSING
UPDATED
,⭐ HYPERSENSITIVITY & IMMUNOLOGY
1. What is hypersensitivity type IV?
A. Immediate IgE-mediated
B. Immune complex–mediated
C. Delayed-type hypersensitivity
D. Antibody-mediated cytotoxic
Answer: C
Rationale: Type IV is delayed, T-cell–mediated hypersensitivity.
2. Hypersensitivity type IV is mediated by what?
A. IgE
B. IgG
C. Complement
D. T-cells
Answer: D
Rationale: Type IV mechanisms rely on T-cell activation.
3. Which is an example of hypersensitivity type IV?
A. Anaphylaxis
B. Serum sickness
C. Mantoux TB skin test
D. Graves disease
Answer: C
Rationale: The TB skin test is classic delayed hypersensitivity.
4. Organ rejection is associated with which hypersensitivity?
A. Type I
B. Type II
C. Type IV
D. Both B & C
Answer: D
Rationale: Transplant rejection involves antibody-mediated (II) and T-cell–mediated (IV)
mechanisms.
, 5. Contact dermatitis is which type of reaction?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: D
Rationale: Poison ivy/contact dermatitis is T-cell–mediated.
6. Anaphylaxis is what type of hypersensitivity?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: A
Rationale: IgE-mediated mast cell degranulation causes anaphylaxis.
7. Graves disease is which hypersensitivity type?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: B
Rationale: Antibody-mediated receptor stimulation is Type II.
8. Serum sickness is which type?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: C
Rationale: Immune complex deposition defines Type III.
