PHA 317 Final Cumulative Exam Questions with Verified Solutions Graded A+
Which of the following factors can affect diffusion of drug? i.Concentration gradient
ii.Particle size
iii.Thickness of the diffusion barrier
a.Only i is correct
b.Only ii is correct
c.Only iii is correct
d.All I, ii and iii are correct
e.None of the options is correct - Answers d.All I, ii and iii are correct
Which of the following statements about zero order reaction is/are correct?
i.The rate of reaction is dependent on the concentration of reactant(s).
ii.The half-life = 0.693/k where k is zero order reaction rate constant. a. Only i is correct
b. Only ii is correct
c. Both are correct
d.Neither i nor ii is correct. - Answers d.Neither i nor ii is correct.
The degradation of local anesthetic procaine can be prevented by making its complex with
a.caffeine
b.calcium
c.sodium
d.potassium - Answers a.caffeine
A drug may be degraded chemically by
i.either hydrolysis or oxidation but not by both
ii.either hydrolysis or oxidation and even by both
a.only (i) is correct
b.neither (i) nor (ii) is correct
,c.only (ii) is correct
d.both (i) and (ii) are correct - Answers c.only (ii) is correct
The empty spaces in parenteral vials or ampoules are filled with nitrogen to prevent the
degradation of drugs by:
a.oxidation
b.photolysis
c.isomerization
d.hydrolysis - Answers a.oxidation
Which is not effective against photolysis?
a.using an amber colored container
b.coating a tablet with cellulose acetate phthalate
c.coating a tablet with UV absorbing material such as vinyl acetate containing oxybenzone.
d.storing in the dark - Answers b.coating a tablet with cellulose acetate phthalate
The overall degradation in case of a suspension is usually:
a. zero order
b.second order
c.third order
d.None of the above - Answers a. zero order
In a zero order reaction, the rate of decomposition is dependent on the concentration of one of
the reactants.
a.True
b.False - Answers b.False
In a zero order reaction:
i.the rate of decomposition is dependent on the concentration of one of the reactants
ii.the rate of decomposition is independent of the concentration of reactants
iii.A plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k
, a.only ii is correct
b.none is correct
c.only iii is correct
d.only i is correct - Answers a.only ii is correct
In a zero order reaction:
i.the half-life is equal to 0.693/k
ii.the unit of k is concentration / time
iii.a plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k
a.none is correct
b.only ii is correct
c.only i is correct
d.only iii is correct - Answers b.only ii is correct
In a second order reaction:
i.The rate of reaction depends on the concentration of two reacting species.
ii.A plot of time (as abscissa) against ቂబ◌ି ௫ బቃ (as ordinate) is linear with a slope equal to
1/k2
iii.The half-life is independent of concentration
a.none is correct
b.only i is correct
c.only iii is correct
d.only i and ii are correct - Answers d.only i and ii are correct
In a study of the hydrolysis of a drug in aqueous solution a plot of logarithm of the amount of
the drug remaining (as ordinate) against time (abscissa) is linear:
i.the reaction is zero order
ii.the slope is -2.303/k.
iii.the half-life does not depends on the initial concentration of reactant
Which of the following factors can affect diffusion of drug? i.Concentration gradient
ii.Particle size
iii.Thickness of the diffusion barrier
a.Only i is correct
b.Only ii is correct
c.Only iii is correct
d.All I, ii and iii are correct
e.None of the options is correct - Answers d.All I, ii and iii are correct
Which of the following statements about zero order reaction is/are correct?
i.The rate of reaction is dependent on the concentration of reactant(s).
ii.The half-life = 0.693/k where k is zero order reaction rate constant. a. Only i is correct
b. Only ii is correct
c. Both are correct
d.Neither i nor ii is correct. - Answers d.Neither i nor ii is correct.
The degradation of local anesthetic procaine can be prevented by making its complex with
a.caffeine
b.calcium
c.sodium
d.potassium - Answers a.caffeine
A drug may be degraded chemically by
i.either hydrolysis or oxidation but not by both
ii.either hydrolysis or oxidation and even by both
a.only (i) is correct
b.neither (i) nor (ii) is correct
,c.only (ii) is correct
d.both (i) and (ii) are correct - Answers c.only (ii) is correct
The empty spaces in parenteral vials or ampoules are filled with nitrogen to prevent the
degradation of drugs by:
a.oxidation
b.photolysis
c.isomerization
d.hydrolysis - Answers a.oxidation
Which is not effective against photolysis?
a.using an amber colored container
b.coating a tablet with cellulose acetate phthalate
c.coating a tablet with UV absorbing material such as vinyl acetate containing oxybenzone.
d.storing in the dark - Answers b.coating a tablet with cellulose acetate phthalate
The overall degradation in case of a suspension is usually:
a. zero order
b.second order
c.third order
d.None of the above - Answers a. zero order
In a zero order reaction, the rate of decomposition is dependent on the concentration of one of
the reactants.
a.True
b.False - Answers b.False
In a zero order reaction:
i.the rate of decomposition is dependent on the concentration of one of the reactants
ii.the rate of decomposition is independent of the concentration of reactants
iii.A plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k
, a.only ii is correct
b.none is correct
c.only iii is correct
d.only i is correct - Answers a.only ii is correct
In a zero order reaction:
i.the half-life is equal to 0.693/k
ii.the unit of k is concentration / time
iii.a plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k
a.none is correct
b.only ii is correct
c.only i is correct
d.only iii is correct - Answers b.only ii is correct
In a second order reaction:
i.The rate of reaction depends on the concentration of two reacting species.
ii.A plot of time (as abscissa) against ቂబ◌ି ௫ బቃ (as ordinate) is linear with a slope equal to
1/k2
iii.The half-life is independent of concentration
a.none is correct
b.only i is correct
c.only iii is correct
d.only i and ii are correct - Answers d.only i and ii are correct
In a study of the hydrolysis of a drug in aqueous solution a plot of logarithm of the amount of
the drug remaining (as ordinate) against time (abscissa) is linear:
i.the reaction is zero order
ii.the slope is -2.303/k.
iii.the half-life does not depends on the initial concentration of reactant
