COMPLETE QUESTIONS AND SOLUTIONS
◉ is it the nurses job to know the cost of medications. Answer: no
◉ what can not be taken with any medication. Answer: grapefruit
◉ what order is the pharmackinetic phase. Answer: absorption,
distribution, metabolism, exceretion
◉ where does absorption occur. Answer: occurs in the small
intestine
◉ where does distribution occur. Answer: occurs in the blood
circulation and tissues
◉ where does metabolism occur. Answer: occurs in the liver
◉ where does exceretion occur. Answer: occurs in the kidneys
◉ disintegration is what. Answer: the breakdown of PO drug form
into small particules
,◉ dissolution is what. Answer: process of combining small drug
particules with liquid to form a solution
◉ drug absorption is what. Answer: drug movement from GI tract
into the bloodstream
◉ why can't you use grapefruit. Answer: the acidity mixes with the
acid in tummy, speeds up absorption and metabolism
◉ is a drug 100% of medication. Answer: no it has fillers
◉ what factors affect medication absorption. Answer: blood
circulation, pain, stress, exercise, food texture(fat content, temp), pH,
route of admin
◉ factors affecting oral meds. Answer: first pass effect,
bioavailability
◉ what is bioavailability. Answer: the percentage thats left for body
to use
◉ what does first pass only effect. Answer: oral and GI
, ◉ factors of bioavailabilty. Answer: absorption, first pass effect, drug
form, route of administration, gastric mucosa and mobility, admin
with food, change in liver metabolism
◉ drug distribution is what. Answer: once the drug leaves the GI
tract
◉ drug distribution involves what. Answer: movement of drug from
circulation to body tissue, protein binding, and free drugs
◉ protein binding percentage used. Answer: 40% to protein 60%
used to body
◉ drug metabolism (biotransformation) is what. Answer: process of
body chemically changing a drug into a form to be excreted, uses half
life and loading dose
◉ half life is what. Answer: time it takes for amount of drug in body
to be reduced by half
◉ loading dose is what. Answer: a higher dose given at the
beginning of treatment