CPIA EXAM QUESTIONS AND ANSWERS 2025
USDA-APHIS Animal Care Resource Policy #12 "Considerations of Alternatives to Painful/Distressful
Procedures" states that when a database search is the primary means of considerations to alternatives
of painful and distressful procedures, that a narrative should include all of the following except:
A. The name of the databases searched
B. The date the search was performed
C. The specific field of study
D. The search strategy (including scientifically relevant terminology) used - (ANSWER)C. The specific field
of study
Which of the following should be considered a significant change to an animal use proposal?
A. change in departmental affiliation of the principal investigator
B. change in start date of study
C. change in anesthetic agent
D. change in fluid administration - (ANSWER)C. change in anesthetic agent
Which of the following entities are required to release information per the Freedom of Information Act?
A. OLAW
B. AAALAC
C. IACUC
D. HSUS - (ANSWER)A. OLAW
Training and instruction of personnel must include guidance in which of the following areas?
A. Effective writing of animal use proposals
B. Proper use of personal protective equipment
C. Appropriate communication with animal activist groups
D. Research or testing methods that limit the use of animals - (ANSWER)D. Research or testing methods
that limit the use of animals
Which of the following procedures may correctly be applied to Designated Member Review?
,CPIA EXAM QUESTIONS AND ANSWERS 2025
A. The IACUC Chair appoints one member to do the Designated Member Review.
B. The designated member reviewer is authorized to approve, require modifications, or disapprove the
proposal.
C. All members receive information about the proposal and send their votes to the designated member
reviewer for tallying.
D. Designated member review may be utilized to review proposals when there is insufficient time to
notify the full membership of the proposal details. - (ANSWER)A. The IACUC Chair appoints one member
to do the Designated Member Review.
In which of the following circumstances may animal work begin before receipt of IACUC approval?
A. It is a continuing study awaiting three year renewal and for which the renewal protocol has been
submitted to the IACUC.
B. It is a small pilot study on non-AWAR species.
C. It is a teaching activity that uses students' personally owned dogs and cats.
D. There are no circumstances in which animal work may begin before IACUC approval. - (ANSWER)D.
There are no circumstances in which animal work may begin before IACUC approval.
Which of the statements below about the responsibility and authority of the Institutional Official (IO) is
false?
A. The IO must have authority to commit institutional resources in support of the animal care and use
program.
B. The IO must be the institution's Chief Executive Officer or some appointed by him with authority to
fund resources.
C. The IO may reinstate an animal activity that was previously suspended by the IACUC.
D. The IO may suspend an animal activity that was previously approved by the IACUC. - (ANSWER)C. The
IO may reinstate an animal activity that was previously suspended by the IACUC.
With regard to conducting official IACUC business, the definition of a quorum is:
A. More than fifty percent (a majority) of voting members.
B. Fifty percent of voting and non-voting members combined.
C. More than fifty percent (a majority) of voting and non-voting members combined.
,CPIA EXAM QUESTIONS AND ANSWERS 2025
D. Fifty percent of the voting members. - (ANSWER)A. More than fifty percent (a majority) of voting
members
The proper sequence for a designated member review by the IACUC is:
A. Review materials are sent to all voting members, full committee review is not requested by any
member, the chairperson assigns one or more IACUC members as designated reviewers.
B. Review materials are sent to a quorum of designated reviewers, review results are solicited from
designated reviewers, full committee approval of results is requested.
C. Review materials are sent to all voting members, a majority of members do not request full
committee review, the chairperson assigns one or more IACUC members as designated reviewers.
D. Review materials are sent to a quorum of voting members, a majority of a quorum does not request
full committee review, the chairperson assigns one or more IACUC members as designated reviewers. -
(ANSWER)A. Review materials are sent to all voting members, full committee review is not requested by
any member, the chairperson assigns one or more IACUC members as designated reviewers.
Notifying investigators of IACUC protocol review outcomes in writing is:
A. A common courtesy not required by regulatory authorities.
B. Allowed by the USDA Animal Welfare Act Regulations and PHS Policy only after the minutes have
been prepared and approved by the IACUC during a convened meeting.
C. Required by both the USDA Animal Welfare Act Regulations and PHS Policy.
D. Allowed by the USDA Animal Welfare Act Regulations and PHS Policy only after the IO is notified of
the review outcome. - (ANSWER)C. Required by both the USDA Animal Welfare Act Regulations and PHS
Policy.
According to the Animal Welfare Act Regulations of the USDA, when conducting a semi-annual
evaluation, the IACUC must conduct the evaluation:
A. With at least 1 IACUC member and allow participation by any member who wishes to do so.
B. With at least 2 IACUC members and allow participation by any member who wishes to do so.
C. With a majority of IACUC members present, including the non-affiliated member.
D. With all IACUC members present. - (ANSWER)B. With at least 2 IACUC members and allow
participation by any member who wishes to do so.
, CPIA EXAM QUESTIONS AND ANSWERS 2025
Who is given the authority to decide if a deficiency identified during a semi-annual IACUC evaluation is
significant or minor?
A. The IACUC and IO together.
B. The veterinarian and the IACUC together.
C. Only the IACUC.
D. Only the IO. - (ANSWER)A. The IACUC and IO together.
What information must be provided in the report for deficiencies identified during the IACUC semi-
annual self-evaluation?
A. A reasonable and specific plan and schedule for correcting significant deficiencies, and a description
of minor deficiencies.
B. A reasonable and specific plan for correcting significant and minor deficiencies and a schedule for
completing the corrective actions.
C. The name and title of the IACUC member who will perform the corrections and the institutional
official in charge of verifying the corrections.
D. The name and title of institutional support personnel who will provide the corrections and the IACUC
members in charge of verifying the corrections. - (ANSWER)B. A reasonable and specific plan for
correcting significant and minor deficiencies and a schedule for completing the corrective actions.
Which of the following institutions must follow the PHS Policy?
A. Institutions that use any animals for research, teaching, or testing.
B. Institutions that use vertebrate animals for research, teaching, or testing.
C. Institutions that accept USDA research funds.
D. Institutions that accept PHS funding. - (ANSWER)D. Institutions that accept PHS funding.
The three Rs of Russell and Burch stand for what?
A. Research, refinement, and recovery.
B. Replace, recognize, and recover.
C. Replacement, reduction, and refinement.
D. Research, results, and review. - (ANSWER)C. Replacement, reduction, and refinement.
USDA-APHIS Animal Care Resource Policy #12 "Considerations of Alternatives to Painful/Distressful
Procedures" states that when a database search is the primary means of considerations to alternatives
of painful and distressful procedures, that a narrative should include all of the following except:
A. The name of the databases searched
B. The date the search was performed
C. The specific field of study
D. The search strategy (including scientifically relevant terminology) used - (ANSWER)C. The specific field
of study
Which of the following should be considered a significant change to an animal use proposal?
A. change in departmental affiliation of the principal investigator
B. change in start date of study
C. change in anesthetic agent
D. change in fluid administration - (ANSWER)C. change in anesthetic agent
Which of the following entities are required to release information per the Freedom of Information Act?
A. OLAW
B. AAALAC
C. IACUC
D. HSUS - (ANSWER)A. OLAW
Training and instruction of personnel must include guidance in which of the following areas?
A. Effective writing of animal use proposals
B. Proper use of personal protective equipment
C. Appropriate communication with animal activist groups
D. Research or testing methods that limit the use of animals - (ANSWER)D. Research or testing methods
that limit the use of animals
Which of the following procedures may correctly be applied to Designated Member Review?
,CPIA EXAM QUESTIONS AND ANSWERS 2025
A. The IACUC Chair appoints one member to do the Designated Member Review.
B. The designated member reviewer is authorized to approve, require modifications, or disapprove the
proposal.
C. All members receive information about the proposal and send their votes to the designated member
reviewer for tallying.
D. Designated member review may be utilized to review proposals when there is insufficient time to
notify the full membership of the proposal details. - (ANSWER)A. The IACUC Chair appoints one member
to do the Designated Member Review.
In which of the following circumstances may animal work begin before receipt of IACUC approval?
A. It is a continuing study awaiting three year renewal and for which the renewal protocol has been
submitted to the IACUC.
B. It is a small pilot study on non-AWAR species.
C. It is a teaching activity that uses students' personally owned dogs and cats.
D. There are no circumstances in which animal work may begin before IACUC approval. - (ANSWER)D.
There are no circumstances in which animal work may begin before IACUC approval.
Which of the statements below about the responsibility and authority of the Institutional Official (IO) is
false?
A. The IO must have authority to commit institutional resources in support of the animal care and use
program.
B. The IO must be the institution's Chief Executive Officer or some appointed by him with authority to
fund resources.
C. The IO may reinstate an animal activity that was previously suspended by the IACUC.
D. The IO may suspend an animal activity that was previously approved by the IACUC. - (ANSWER)C. The
IO may reinstate an animal activity that was previously suspended by the IACUC.
With regard to conducting official IACUC business, the definition of a quorum is:
A. More than fifty percent (a majority) of voting members.
B. Fifty percent of voting and non-voting members combined.
C. More than fifty percent (a majority) of voting and non-voting members combined.
,CPIA EXAM QUESTIONS AND ANSWERS 2025
D. Fifty percent of the voting members. - (ANSWER)A. More than fifty percent (a majority) of voting
members
The proper sequence for a designated member review by the IACUC is:
A. Review materials are sent to all voting members, full committee review is not requested by any
member, the chairperson assigns one or more IACUC members as designated reviewers.
B. Review materials are sent to a quorum of designated reviewers, review results are solicited from
designated reviewers, full committee approval of results is requested.
C. Review materials are sent to all voting members, a majority of members do not request full
committee review, the chairperson assigns one or more IACUC members as designated reviewers.
D. Review materials are sent to a quorum of voting members, a majority of a quorum does not request
full committee review, the chairperson assigns one or more IACUC members as designated reviewers. -
(ANSWER)A. Review materials are sent to all voting members, full committee review is not requested by
any member, the chairperson assigns one or more IACUC members as designated reviewers.
Notifying investigators of IACUC protocol review outcomes in writing is:
A. A common courtesy not required by regulatory authorities.
B. Allowed by the USDA Animal Welfare Act Regulations and PHS Policy only after the minutes have
been prepared and approved by the IACUC during a convened meeting.
C. Required by both the USDA Animal Welfare Act Regulations and PHS Policy.
D. Allowed by the USDA Animal Welfare Act Regulations and PHS Policy only after the IO is notified of
the review outcome. - (ANSWER)C. Required by both the USDA Animal Welfare Act Regulations and PHS
Policy.
According to the Animal Welfare Act Regulations of the USDA, when conducting a semi-annual
evaluation, the IACUC must conduct the evaluation:
A. With at least 1 IACUC member and allow participation by any member who wishes to do so.
B. With at least 2 IACUC members and allow participation by any member who wishes to do so.
C. With a majority of IACUC members present, including the non-affiliated member.
D. With all IACUC members present. - (ANSWER)B. With at least 2 IACUC members and allow
participation by any member who wishes to do so.
, CPIA EXAM QUESTIONS AND ANSWERS 2025
Who is given the authority to decide if a deficiency identified during a semi-annual IACUC evaluation is
significant or minor?
A. The IACUC and IO together.
B. The veterinarian and the IACUC together.
C. Only the IACUC.
D. Only the IO. - (ANSWER)A. The IACUC and IO together.
What information must be provided in the report for deficiencies identified during the IACUC semi-
annual self-evaluation?
A. A reasonable and specific plan and schedule for correcting significant deficiencies, and a description
of minor deficiencies.
B. A reasonable and specific plan for correcting significant and minor deficiencies and a schedule for
completing the corrective actions.
C. The name and title of the IACUC member who will perform the corrections and the institutional
official in charge of verifying the corrections.
D. The name and title of institutional support personnel who will provide the corrections and the IACUC
members in charge of verifying the corrections. - (ANSWER)B. A reasonable and specific plan for
correcting significant and minor deficiencies and a schedule for completing the corrective actions.
Which of the following institutions must follow the PHS Policy?
A. Institutions that use any animals for research, teaching, or testing.
B. Institutions that use vertebrate animals for research, teaching, or testing.
C. Institutions that accept USDA research funds.
D. Institutions that accept PHS funding. - (ANSWER)D. Institutions that accept PHS funding.
The three Rs of Russell and Burch stand for what?
A. Research, refinement, and recovery.
B. Replace, recognize, and recover.
C. Replacement, reduction, and refinement.
D. Research, results, and review. - (ANSWER)C. Replacement, reduction, and refinement.
