MEDICINAL CHEMESTLY WITH
ACTUAL QUESTIONS AND DETAILD
VERIFIED ANSWERS ALREADY
GRADED A+
Pharmacokinetics - ANSWER✔✔✨---The bioavailability of the drug; The drug must reach its target in
a high enough of concentration for sufficient duration in order to produce a biological response
Enteral administration - ANSWER✔✔✨---Oral/non-oral (GI Tract)
Parenteral administration - ANSWER✔✔✨---Intravascular (IV injection, IV infusion, IA) /
Extravascular (IM, Sub-Q, intra-epidural, inhalation, topical)
Compartment - ANSWER✔✔✨---Group of tissues with similar blood flow and drug affinity
Injection - ANSWER✔✔✨---Single dose placed directly into the blood stream
Infusion - ANSWER✔✔✨---Steady delivery of drug to the blood stream. Plasma [drug] will increase
until rate of infusion=rate of elinminatiom
What is the blood volume - ANSWER✔✔✨---Normally 5L per 70kg person or 0.071 L/kg
Values < 0.071 L/kg - ANSWER✔✔✨---Drug is found mainly in the circulatory system
Values > 0.071 L/kg - ANSWER✔✔✨---Drug is found in both circulatory system and certain tissues
, Biological half-life - ANSWER✔✔✨---Time taken for the concentration of the drug to fall to half its
original value
T1/2 equation - ANSWER✔✔✨---T1/2= 0.693/Kel
Lead (short duration) - ANSWER✔✔✨---Drugs with longer t1/2 and smaller Kel values can be
designed
Lead (too toxic) - ANSWER✔✔✨---Drugs with smaller t1/2 and larger Kel should be designed
Clearance (Cl) - ANSWER✔✔✨---Defined as the volume of blood in a specified region of the body
that is cleared of a drug in unit time
Total clearance (ClT) - ANSWER✔✔✨---Total body blood volume cleared of a drug in unit time
Steady state - ANSWER✔✔✨---The rates are equal and plasma concentration does not change: Css =
Cp
Zero-order reactions - ANSWER✔✔✨----Order=0
-Constant rate
-Rate is dependent of concentration of reactants
-rate law: rate=k [A] (or B) with k units is 1/sec
First-order reactions - ANSWER✔✔✨----Order=1
-Rate is proportional to concentration of one of the reactants
-rate law: rate=k [A] (or B) with k units is 1/sec
Second-order reactions - ANSWER✔✔✨----Order=2
-rate is proportional to concentration of the square of a single reactant or the product of concentration
of 2 reactants
ACTUAL QUESTIONS AND DETAILD
VERIFIED ANSWERS ALREADY
GRADED A+
Pharmacokinetics - ANSWER✔✔✨---The bioavailability of the drug; The drug must reach its target in
a high enough of concentration for sufficient duration in order to produce a biological response
Enteral administration - ANSWER✔✔✨---Oral/non-oral (GI Tract)
Parenteral administration - ANSWER✔✔✨---Intravascular (IV injection, IV infusion, IA) /
Extravascular (IM, Sub-Q, intra-epidural, inhalation, topical)
Compartment - ANSWER✔✔✨---Group of tissues with similar blood flow and drug affinity
Injection - ANSWER✔✔✨---Single dose placed directly into the blood stream
Infusion - ANSWER✔✔✨---Steady delivery of drug to the blood stream. Plasma [drug] will increase
until rate of infusion=rate of elinminatiom
What is the blood volume - ANSWER✔✔✨---Normally 5L per 70kg person or 0.071 L/kg
Values < 0.071 L/kg - ANSWER✔✔✨---Drug is found mainly in the circulatory system
Values > 0.071 L/kg - ANSWER✔✔✨---Drug is found in both circulatory system and certain tissues
, Biological half-life - ANSWER✔✔✨---Time taken for the concentration of the drug to fall to half its
original value
T1/2 equation - ANSWER✔✔✨---T1/2= 0.693/Kel
Lead (short duration) - ANSWER✔✔✨---Drugs with longer t1/2 and smaller Kel values can be
designed
Lead (too toxic) - ANSWER✔✔✨---Drugs with smaller t1/2 and larger Kel should be designed
Clearance (Cl) - ANSWER✔✔✨---Defined as the volume of blood in a specified region of the body
that is cleared of a drug in unit time
Total clearance (ClT) - ANSWER✔✔✨---Total body blood volume cleared of a drug in unit time
Steady state - ANSWER✔✔✨---The rates are equal and plasma concentration does not change: Css =
Cp
Zero-order reactions - ANSWER✔✔✨----Order=0
-Constant rate
-Rate is dependent of concentration of reactants
-rate law: rate=k [A] (or B) with k units is 1/sec
First-order reactions - ANSWER✔✔✨----Order=1
-Rate is proportional to concentration of one of the reactants
-rate law: rate=k [A] (or B) with k units is 1/sec
Second-order reactions - ANSWER✔✔✨----Order=2
-rate is proportional to concentration of the square of a single reactant or the product of concentration
of 2 reactants
