Pharmacotherapy Exam 2 questions well
answered graded A+
1. osteoarthritis is a
degenerative
(degenera-
tive/inflammatory) disease normal articular cartilage is gradually worn away as
a result of mechanical and biological processes
2. describe the pathophysiology
of osteoarthritis
3. what are disease-modifying drugs we don't have any
for OA?
4. goals of OA treatment (3) 1. control pain
2. minimize disability
3. educate the patient
5. what are the main joints hands, hips, knees
affected by OA?
6. what are the three main GI ulcers, AKI, CV ettects
toxicities of NSAIDs?
7. what percentage of patients 5-20%
tak- ing long-term NSAIDs
develop peptic ulcer?
8. what is the MOA of aceta- glucuronidation metabolic pathway is saturated,
there-
minophen in causing hepatotoxic- fore CYP2E1 metabolizes acetaminophen to
a toxic
ity? affect of intra-articular
steroids for OA?
9. what is one major adverse
1/
25
,Pharmacotherapy Exam 2 questions well
answered graded A+
10. what are adverse effects of metabolite
glu- cosamine/chondroitin?
it hastens disease progression
nausea, GI upset, enhanced blood thinning
ettects, glu- cose intolerance
11. false (neither)
2/
25
, Pharmacotherapy Exam 2 questions well
answered graded A+
T/F: glucosamine/chondroitin are
recommended by ACR and
NICE guidelines
12. what is first-line therapy for
acetaminophen
treat- ing OA pain?
13. there is very limited pain, physical function
evidence for the ability of
NSAIDs to relieve
and improve
related to NSAIDs
OA
14. ACR Guidelines for OA rank
what class of drug as most
effective for hand, knee, and
hip?
15. when initiating oral NSAIDs, which ibuprofen, naproxen
two are typically used fist?
16. for which joint do the ACR hyaluronic acid, glu-
OA Guidelines conditionally cosamine, and chondroitin?
recom- mend capsaicin?
17. for which joint do the ACR
OA Guidelines strongly
recommend topical NSAIDs?
18. what are the ACR OA
Guidelines' opinions on
3/
25
answered graded A+
1. osteoarthritis is a
degenerative
(degenera-
tive/inflammatory) disease normal articular cartilage is gradually worn away as
a result of mechanical and biological processes
2. describe the pathophysiology
of osteoarthritis
3. what are disease-modifying drugs we don't have any
for OA?
4. goals of OA treatment (3) 1. control pain
2. minimize disability
3. educate the patient
5. what are the main joints hands, hips, knees
affected by OA?
6. what are the three main GI ulcers, AKI, CV ettects
toxicities of NSAIDs?
7. what percentage of patients 5-20%
tak- ing long-term NSAIDs
develop peptic ulcer?
8. what is the MOA of aceta- glucuronidation metabolic pathway is saturated,
there-
minophen in causing hepatotoxic- fore CYP2E1 metabolizes acetaminophen to
a toxic
ity? affect of intra-articular
steroids for OA?
9. what is one major adverse
1/
25
,Pharmacotherapy Exam 2 questions well
answered graded A+
10. what are adverse effects of metabolite
glu- cosamine/chondroitin?
it hastens disease progression
nausea, GI upset, enhanced blood thinning
ettects, glu- cose intolerance
11. false (neither)
2/
25
, Pharmacotherapy Exam 2 questions well
answered graded A+
T/F: glucosamine/chondroitin are
recommended by ACR and
NICE guidelines
12. what is first-line therapy for
acetaminophen
treat- ing OA pain?
13. there is very limited pain, physical function
evidence for the ability of
NSAIDs to relieve
and improve
related to NSAIDs
OA
14. ACR Guidelines for OA rank
what class of drug as most
effective for hand, knee, and
hip?
15. when initiating oral NSAIDs, which ibuprofen, naproxen
two are typically used fist?
16. for which joint do the ACR hyaluronic acid, glu-
OA Guidelines conditionally cosamine, and chondroitin?
recom- mend capsaicin?
17. for which joint do the ACR
OA Guidelines strongly
recommend topical NSAIDs?
18. what are the ACR OA
Guidelines' opinions on
3/
25
