correct answers graded A+
1. What are the four main anti-depressant classes? -SSRI
-SNRI
-TCA
-MAOI
2. are the most common anti-depressant used. SSRI's
They are very well tolerated and are
indicated to treat Depression, OCD, PTSD,
panic disorder, Gener- alized Anxiety Disorder,
Pre-Menstrual Dysmorphic Disorder, Social
anxiety disorder, and eating disor- ders
3. Fluoxetine (Prozac) first introduced in 1988
4. All are equally effective and are often the first SSRI's
line in treating depression disorders
5. has the longest half-life of all the SSRI's Fluoxetine (Prozac)
(4 - 6 days) and is used to treat Depression,
OCD (adult and peds), bulimia, panic
disorder, premen- strual dysphoric disorder
as well as Anorexia ner- vosa, premenstrual
syndrome, bi-polar disorder
6. SSRI's are metabolized in the liver by the
enzymes cytochrome P450
7. The mechanism of action of is to inhibit re-up-
SSRI's take of 5-HT making more serotonin
available in the synaptic cleft.
8. What SSRI weakly inhibits norepi re-uptake? Prozac
,Exam 1; Pharmacotherapy questions with
correct answers graded A+
9. Zoloft
, Exam 1; Pharmacotherapy questions with
correct answers graded A+
What SSRI weakly inhibits norepi and dopamine
re- uptake?
10. What SSRI has significant anticholinergic Paxil
activity at higher doses?
11. What anti-depressant class has side effectsSSRI's
that in- clude headache, dizziness, nausea,
diarrhea, insom- nia, and sexual dysfunction?
°Sometimes can take up to 6
months or so to adapt
and overcome sexual
dysfunction. If this is
troublesome to pa- tients,
consider a ditterent
class of drug
12. Sudden withdrawal of may present as flu-
like symptoms including nausea, fatigue, SSRIs
myalgias, ver- tigo, and headache. (not
fatal- just uncomfortable) °Treatment is reinstatement of
SSRI and gradual
tapering if pt wants ott
SSRI*
13. What are the 6 SSRI's? 1) Citalopram (Celexa)
2) Escitalopram
(Lexapro)
3) Fluoxetine
(Prozac, Ser- afem)
4) Fluvoxamine
(Luvox)
5) Paroxetine (Paxil)