MCB 4271 FINAL EXAM T/F QUESTIONS
According to the WHO, antimicrobial resistance is one of the biggest threats to global
health and food security today. - Answer -TRUE
Clavams are very potent antibiotics - Answer -FALSE
Carbapenems are effective against 98% of bacterial strains isolated from hospitals.
There is a special caution of using this antibiotic to avoid the development of resistance
- Answer -TRUE
Trimethoprim binds to human DHFR - Answer -FALSE
inhibiting DNA synthesis arrests the cell cycle but does not kill cells. Hence,
trimethoprim is classified as a bacteriostatic antibiotic - Answer -TRUE
Sulfanilamide is an antibiotic - Answer -FALSE
Structural differences between eukaryotic and prokaryotic machinery involved in the
Central Dogma of Molecular Biology (replication, transcription, translation) allow for the
development of antibiotics that specifically target microbial cells. - Answer -TRUE
Quinolone antibiotics target DNA gyrase and topoisomerase IV. These type II
topoisomerases are also found in the human proteome - Answer -FALSE
Tetracyclines bind to the 50S ribosomal subunit - Answer -FALSE
Chloramphenicol binds to the 50S ribosomal subunit and inhibits peptidyl transferase -
Answer -TRUE
Efflux pumps permit diffusion of molecules across the plasma membrane. Hence, they
do not require energy - Answer -FALSE
Staphylococcus aureus is the cause of the most common hospital-acquired infections -
Answer -TRUE
Transposons, or "jumping genes" can facilitate the transposition of resistance genes
during vertical gene transfer - Answer -FALSE
~30% of world's population is colonized by S. aureus - Answer -TRUE
GLASS collects information on both viral and bacterial infections - Answer -FALSE
According to the WHO, antimicrobial resistance is one of the biggest threats to global
health and food security today. - Answer -TRUE
Clavams are very potent antibiotics - Answer -FALSE
Carbapenems are effective against 98% of bacterial strains isolated from hospitals.
There is a special caution of using this antibiotic to avoid the development of resistance
- Answer -TRUE
Trimethoprim binds to human DHFR - Answer -FALSE
inhibiting DNA synthesis arrests the cell cycle but does not kill cells. Hence,
trimethoprim is classified as a bacteriostatic antibiotic - Answer -TRUE
Sulfanilamide is an antibiotic - Answer -FALSE
Structural differences between eukaryotic and prokaryotic machinery involved in the
Central Dogma of Molecular Biology (replication, transcription, translation) allow for the
development of antibiotics that specifically target microbial cells. - Answer -TRUE
Quinolone antibiotics target DNA gyrase and topoisomerase IV. These type II
topoisomerases are also found in the human proteome - Answer -FALSE
Tetracyclines bind to the 50S ribosomal subunit - Answer -FALSE
Chloramphenicol binds to the 50S ribosomal subunit and inhibits peptidyl transferase -
Answer -TRUE
Efflux pumps permit diffusion of molecules across the plasma membrane. Hence, they
do not require energy - Answer -FALSE
Staphylococcus aureus is the cause of the most common hospital-acquired infections -
Answer -TRUE
Transposons, or "jumping genes" can facilitate the transposition of resistance genes
during vertical gene transfer - Answer -FALSE
~30% of world's population is colonized by S. aureus - Answer -TRUE
GLASS collects information on both viral and bacterial infections - Answer -FALSE
