Module 2 EXAM QUESTIONS WITH
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Methenamine - ANSWER ✓ MOA = decomposes ammonia into formaldehyde ->
denature bacterial proteins
use = chronic lower UTI (TMP/SMZ preferred drug)
AE = contraindicated in renal and liver failure
interacts w. urinary alkalinizers, sulfonamides
fluroquinolones MOA - ANSWER ✓ disrupts DNA replication & cell division
Ofloxacin, Moxifloxacin, Norfloxacin- no longer available in US, Levofloxacin,
Gemifloxacin, Delafloxacin
Ciprofloxacin - ANSWER ✓ MOA = inhibits bacterial DNA
use = drug of choice for anthrax**, respiratory, UTI, GI, cones, joints, skin, soft
tissue
AE - NVD, dizzy, HA, confusion, tendon rupture, candida, increased risk Cdiff;
older adults MG, aortic dissection or ruptured AAA
absorption reduced by aluminum antacids, Mg antacids, iron salts, zinc salts,
sucralfate, milk/dairy
elevation of drug levels w/ theophylline (asthma), warfarin (anticoag), tinidazole
(antifungal)
,Metronidazole - ANSWER ✓ bactericidal
use = protozoal infection, h pylori, c diff
AE = neurotoxicity, allergy, superinfections
daptomycin - ANSWER ✓ MOA = kills gram + bacteria & MRSA
use = sepsis w/ staph aureus, complicated skin infection
AE = possible muscle injury
chancroid - ANSWER ✓ gram negative ballius caused STD
SS = men w/ ulcers surrounded by erythematous halo, necrotic or erosive
chancroid TMT - ANSWER ✓ zithro 1g once OR
ceftriaxone 250mg IM once OR
cirpro 500mg 2x/day
erythromycin 500mg 3x/day for 1 wk
chlamydia s/s & diagnosis - ANSWER ✓ females = often asymptomatic, dysuria,
spotting, postcoital bleeding, dypareunia, vaginal d/c
men = often asymptomatic, dysuria, this cloudy d/c, testicular pain
diagnosis = NAAT gold standard***
chlamydia TMT - ANSWER ✓ doxy 100mg PO BID x1 wk OR
zithro 1g PO once OR
doxy x2 wk if epidymis or PID
pregnant pt = amoxicillin 500mg PO TID x 1 wk
kids <45kg = erthromycin
kids >45 & >8y = zithro
>8yr = zithro or doxy
, genital warts prevention and TMT - ANSWER ✓ prevention: condoms, HPV
vaccine, STD screening
external TMT = podphyllin resin 10-25% q1-2wk, TCA or BCA 80-90%,
cryotherapy, surgery
self TMT external = Imiquimod 3.75% 3x/wk for 16wks
gonorrhea s/s & treatment - ANSWER ✓ men S/S = blood tinged d/c, dysuria,
edema, testicular pain
women S/S = d/c, dysuria, abnormal bleeding, abcess, rectal infection, PID
neonates S/S = conjunctivitis
NAAT to test
TMT = ceftriaxone 500mg IM once
w/ chlamydia = add doxy 100mg 2x/day x 1wk
genital herpes s/s & treatment - ANSWER ✓ S/S = ulcers, HA, malaise, myalgia,
dysuria, puritis
TMT = acyclovir 400mg x1 wk, valacyclovir 1g BID x 3-5days,
Syphillis treatment - ANSWER ✓ penicillin G IM
bacterial vaginosis treatment - ANSWER ✓ metronidazole 500mg BID x1wk,
metronidazole gel 0.75% intravag x5 days
trich treatment - ANSWER ✓ metronidazole 500mg BIDx1wk
men = metronidazole 2g PO once
both = tinidazole 2g once
opportunisitic mycoses - ANSWER ✓ immunocompromised host
candadiasis, aspergillosis, cryptococcosis, mucormycosis
nonopportunistic mycoses - ANSWER ✓ can occur in any host